Arterial thrombosis in four patients treated with thalidomide

Sarah L. Scarpace, Theresa Hahn, Hilary Roy, Karen Brown, Pamela Paplham, Asher Chanan-Khan, Koen Van Besien, Philip L. McCarthy

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Thalidomide has been associated with venous thrombotic events, as reported in the post-marketing surveillance reports by Celgene Corporation; as well as case reports in the literature. Seven arterial thrombotic events have been reported in patients receiving thalidomide with 3 cases occurring in patients with other predisposing conditions. We report 4 additional cases of arterial thromboses in 1 lymphoma and 3 myeloma patients treated with thalidomide. The mechanism for these events is unclear; however, it is significant that 2 patients were receiving concomitant anticoagulation with aspirin and warfarin.

Original languageEnglish (US)
Pages (from-to)239-242
Number of pages4
JournalLeukemia and Lymphoma
Volume46
Issue number2
DOIs
StatePublished - Feb 1 2005

Keywords

  • Arterial thrombosis
  • Cerebral vascular accident
  • Deep vein thrombosis
  • Multiple myeloma
  • Non-Hodgkin's lymphoma
  • Thalidomide

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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