Arterial thrombosis in four patients treated with thalidomide

Sarah L. Scarpace; Theresa Hahn; Hilary Roy; Karen Brown; Pamela Paplham; Asher Chanan-Khan; Koen Van Besien; Philip L. McCarthy

doi:10.1080/10428190400015675

Arterial thrombosis in four patients treated with thalidomide

Sarah L. Scarpace, Theresa Hahn, Hilary Roy, Karen Brown, Pamela Paplham, Asher Chanan-Khan, Koen Van Besien, Philip L. McCarthy

Hematology / Oncology / Cancer Center / Breast Clinic

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Thalidomide has been associated with venous thrombotic events, as reported in the post-marketing surveillance reports by Celgene Corporation; as well as case reports in the literature. Seven arterial thrombotic events have been reported in patients receiving thalidomide with 3 cases occurring in patients with other predisposing conditions. We report 4 additional cases of arterial thromboses in 1 lymphoma and 3 myeloma patients treated with thalidomide. The mechanism for these events is unclear; however, it is significant that 2 patients were receiving concomitant anticoagulation with aspirin and warfarin.

Original language	English (US)
Pages (from-to)	239-242
Number of pages	4
Journal	Leukemia and Lymphoma
Volume	46
Issue number	2
DOIs	https://doi.org/10.1080/10428190400015675
State	Published - Feb 2005

Keywords

Arterial thrombosis
Cerebral vascular accident
Deep vein thrombosis
Multiple myeloma
Non-Hodgkin's lymphoma
Thalidomide

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1080/10428190400015675

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abstract = "Thalidomide has been associated with venous thrombotic events, as reported in the post-marketing surveillance reports by Celgene Corporation; as well as case reports in the literature. Seven arterial thrombotic events have been reported in patients receiving thalidomide with 3 cases occurring in patients with other predisposing conditions. We report 4 additional cases of arterial thromboses in 1 lymphoma and 3 myeloma patients treated with thalidomide. The mechanism for these events is unclear; however, it is significant that 2 patients were receiving concomitant anticoagulation with aspirin and warfarin.",

keywords = "Arterial thrombosis, Cerebral vascular accident, Deep vein thrombosis, Multiple myeloma, Non-Hodgkin's lymphoma, Thalidomide",

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AU - Scarpace, Sarah L.

AU - Hahn, Theresa

AU - Roy, Hilary

AU - Brown, Karen

AU - Paplham, Pamela

AU - Chanan-Khan, Asher

AU - Van Besien, Koen

AU - McCarthy, Philip L.

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AB - Thalidomide has been associated with venous thrombotic events, as reported in the post-marketing surveillance reports by Celgene Corporation; as well as case reports in the literature. Seven arterial thrombotic events have been reported in patients receiving thalidomide with 3 cases occurring in patients with other predisposing conditions. We report 4 additional cases of arterial thromboses in 1 lymphoma and 3 myeloma patients treated with thalidomide. The mechanism for these events is unclear; however, it is significant that 2 patients were receiving concomitant anticoagulation with aspirin and warfarin.

KW - Arterial thrombosis

KW - Cerebral vascular accident

KW - Deep vein thrombosis

KW - Multiple myeloma

KW - Non-Hodgkin's lymphoma

KW - Thalidomide

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Arterial thrombosis in four patients treated with thalidomide

Abstract

Keywords

ASJC Scopus subject areas

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