Arterial Stiffness Estimation by Shear Wave Elastography

Validation in Phantoms with Mechanical Testing

Elira Maksuti, Erik Widman, David Larsson, Matthew W Urban, Matilda Larsson, Anna Bjällmark

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Arterial stiffness is an independent risk factor found to correlate with a wide range of cardiovascular diseases. It has been suggested that shear wave elastography (SWE) can be used to quantitatively measure local arterial shear modulus, but an accuracy assessment of the technique for arterial applications has not yet been performed. In this study, the influence of confined geometry on shear modulus estimation, by both group and phase velocity analysis, was assessed, and the accuracy of SWE in comparison with mechanical testing was measured in nine pressurized arterial phantoms. The results indicated that group velocity with an infinite medium assumption estimated shear modulus values incorrectly in comparison with mechanical testing in arterial phantoms (6.7 ± 0.0 kPa from group velocity and 30.5 ± 0.4 kPa from mechanical testing). To the contrary, SWE measurements based on phase velocity analysis (30.6 ± 3.2 kPa) were in good agreement with mechanical testing, with a relative error between the two techniques of 8.8 ± 6.0% in the shear modulus range evaluated (40-100 kPa). SWE by phase velocity analysis was validated to accurately measure stiffness in arterial phantoms.

Original languageEnglish (US)
Pages (from-to)308-321
Number of pages14
JournalUltrasound in Medicine and Biology
Volume42
Issue number1
DOIs
StatePublished - Jan 1 2016

Fingerprint

Elasticity Imaging Techniques
Vascular Stiffness
S waves
stiffness
phase velocity
group velocity
shear
Cardiovascular Diseases
geometry

Keywords

  • Accuracy
  • Arterial phantom
  • Arterial stiffness
  • Group velocity
  • Lamb waves
  • Mechanical testing
  • Phase velocity
  • Poly(vinyl alcohol)
  • Shear modulus
  • Shear wave elastography

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biophysics
  • Radiology Nuclear Medicine and imaging

Cite this

Arterial Stiffness Estimation by Shear Wave Elastography : Validation in Phantoms with Mechanical Testing. / Maksuti, Elira; Widman, Erik; Larsson, David; Urban, Matthew W; Larsson, Matilda; Bjällmark, Anna.

In: Ultrasound in Medicine and Biology, Vol. 42, No. 1, 01.01.2016, p. 308-321.

Research output: Contribution to journalArticle

Maksuti, Elira ; Widman, Erik ; Larsson, David ; Urban, Matthew W ; Larsson, Matilda ; Bjällmark, Anna. / Arterial Stiffness Estimation by Shear Wave Elastography : Validation in Phantoms with Mechanical Testing. In: Ultrasound in Medicine and Biology. 2016 ; Vol. 42, No. 1. pp. 308-321.
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