Arterial stiffening, wave reflection, and inflammation in habitually exercising systemic lupus erythematosus patients

Jill N. Barnes, Nantinee Nualnim, Jun Sugawara, Shawn M. Sommerlad, Christopher P. Renzi, Hirofumi Tanaka

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background Chronic systemic inflammation has been implicated in the pathogenesis of hypertension and cardiovascular disease. Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by chronic inflammation and an increased risk for cardiovascular disease. Currently few studies have evaluated the potential cardiovascular benefits of exercise in SLE. It is unknown whether the favorable effect of habitual exercise on arterial stiffness observed in healthy adults can be extended to SLE. Therefore, as an initial step, we determined the association between habitual exercise, inflammatory markers, central arterial compliance, and aortic wave reflection in healthy adults and SLE patients. Methods We studied 41 adults, aged 33 ± 11 years (15 healthy controls, 12 sedentary SLE, and 14 physically active SLE patients). Results Age, body mass index, and metabolic risk factors were not different between the three groups. Carotid arterial compliance was lower whereas augmentation index (AI) and inflammatory markers (C-reactive protein (CRP), interleukin (IL)-12, tumor necrosis factor-α (TNF-α)) were higher in sedentary SLE patients compared with healthy controls, but were not different between physically active SLE patients and healthy controls. Cardiac ejection fraction was lower in sedentary SLE than physically active SLE or healthy controls. In the pooled population, carotid arterial compliance was inversely associated with TNF-α (r = 0.38; P < 0.01), and AI was positively associated with both CRP (r = 0.33; P < 0.05) and intercellular adhesion molecule-1 (r = 0.28; P < 0.05). Conclusions SLE-associated stiffening of the central artery and wave reflection were not observed in habitually exercising adults with SLE. Furthermore, greater arterial stiffness was associated with higher inflammatory markers, suggesting that need for studies on inflammation and SLE-associated arterial stiffening.

Original languageEnglish (US)
Pages (from-to)1194-1200
Number of pages7
JournalAmerican Journal of Hypertension
Volume24
Issue number11
DOIs
StatePublished - Nov 2011
Externally publishedYes

Fingerprint

Systemic Lupus Erythematosus
Inflammation
Compliance
Vascular Stiffness
Exercise
C-Reactive Protein
Cardiovascular Diseases
Tumor Necrosis Factor-alpha
Intercellular Adhesion Molecule-1
Interleukin-12
Autoimmune Diseases
Body Mass Index
Arteries
Hypertension

Keywords

  • arterial compliance
  • augmentation index
  • blood pressure
  • chronic inflammation
  • hypertension
  • physical activity

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Arterial stiffening, wave reflection, and inflammation in habitually exercising systemic lupus erythematosus patients. / Barnes, Jill N.; Nualnim, Nantinee; Sugawara, Jun; Sommerlad, Shawn M.; Renzi, Christopher P.; Tanaka, Hirofumi.

In: American Journal of Hypertension, Vol. 24, No. 11, 11.2011, p. 1194-1200.

Research output: Contribution to journalArticle

Barnes, Jill N. ; Nualnim, Nantinee ; Sugawara, Jun ; Sommerlad, Shawn M. ; Renzi, Christopher P. ; Tanaka, Hirofumi. / Arterial stiffening, wave reflection, and inflammation in habitually exercising systemic lupus erythematosus patients. In: American Journal of Hypertension. 2011 ; Vol. 24, No. 11. pp. 1194-1200.
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abstract = "Background Chronic systemic inflammation has been implicated in the pathogenesis of hypertension and cardiovascular disease. Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by chronic inflammation and an increased risk for cardiovascular disease. Currently few studies have evaluated the potential cardiovascular benefits of exercise in SLE. It is unknown whether the favorable effect of habitual exercise on arterial stiffness observed in healthy adults can be extended to SLE. Therefore, as an initial step, we determined the association between habitual exercise, inflammatory markers, central arterial compliance, and aortic wave reflection in healthy adults and SLE patients. Methods We studied 41 adults, aged 33 ± 11 years (15 healthy controls, 12 sedentary SLE, and 14 physically active SLE patients). Results Age, body mass index, and metabolic risk factors were not different between the three groups. Carotid arterial compliance was lower whereas augmentation index (AI) and inflammatory markers (C-reactive protein (CRP), interleukin (IL)-12, tumor necrosis factor-α (TNF-α)) were higher in sedentary SLE patients compared with healthy controls, but were not different between physically active SLE patients and healthy controls. Cardiac ejection fraction was lower in sedentary SLE than physically active SLE or healthy controls. In the pooled population, carotid arterial compliance was inversely associated with TNF-α (r = 0.38; P < 0.01), and AI was positively associated with both CRP (r = 0.33; P < 0.05) and intercellular adhesion molecule-1 (r = 0.28; P < 0.05). Conclusions SLE-associated stiffening of the central artery and wave reflection were not observed in habitually exercising adults with SLE. Furthermore, greater arterial stiffness was associated with higher inflammatory markers, suggesting that need for studies on inflammation and SLE-associated arterial stiffening.",
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