Arterial baroreflex control of heart rate during exercise in postural tachycardia syndrome

Shizue Masuki, John H. Eisenach, William G. Schrage, Niki M. Dietz, Christopher P. Johnson, Brad W. Wilkins, Ross A. Dierkhising, Paola Sandroni, Phillip Anson Low, Michael Joseph Joyner

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Patients with postural tachycardia syndrome (POTS) have excessive tachycardia without hypotension during orthostasis as well as exercise. We tested the hypothesis that excessive tachycardia during exercise in POTS is not related to abnormal baroreflex control of heart rate (HR). Patients (n = 13) and healthy controls (n = 10) performed graded cycle exercise at 25, 50, and 75 W in both supine and upright positions while arterial pressure (arterial catheter) and HR (ECG) were measured. Baroreflex sensitivity of HR was assessed by bolus intravenous infusion of phenylephrine at each workload. In both positions, HR was higher in the patients than the controls during exercise. Supine baroreflex sensitivity (HR/systolic pressure) in POTS patients was -1.3 ± 0.1 beats·min-1·mmHg-1 at rest and decreased to -0.6 ± 0.1 beats·min-1·mmHg-1 during 75-W exercise, neither significantly different from the controls (P > 0.6). In the upright position, baroreflex sensitivity in POTS patients at rest (-1.4 ± 0.1 beats·min-1·mmHg-1) was higher than the controls (-1.0 ± 0.1 beats·min -1·mmHg-1) (P · 0.05), and it decreased to -0.1 ± 0.04 beats·min-1·mmHg-1 during 75-W exercise, lower than the controls (-0.3 ± 0.09 beats· min-1·mmHg-1) (P < 0.05). The reduced arterial baroreflex sensitivity of HR during upright exercise was accompanied by greater fluctuations in systolic and pulse pressure in the patients than in the controls with 56 and 90% higher coefficient of variations, respectively (P < 0.01). However, when baroreflex control of HR was corrected for differences in HR, it was similar between the patients and controls during upright exercise. These results suggest that the tachycardia during exercise in POTS was not due to abnormal baroreflex control of HR.

Original languageEnglish (US)
Pages (from-to)1136-1142
Number of pages7
JournalJournal of Applied Physiology
Volume103
Issue number4
DOIs
StatePublished - Oct 2007

Fingerprint

Postural Orthostatic Tachycardia Syndrome
Baroreflex
Heart Rate
Exercise
Tachycardia
Blood Pressure
Supine Position
Dizziness
Phenylephrine
Workload
Intravenous Infusions
Hypotension
Arterial Pressure
Electrocardiography
Catheters

Keywords

  • Blood pressure
  • Orthostatic intolerance
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Arterial baroreflex control of heart rate during exercise in postural tachycardia syndrome. / Masuki, Shizue; Eisenach, John H.; Schrage, William G.; Dietz, Niki M.; Johnson, Christopher P.; Wilkins, Brad W.; Dierkhising, Ross A.; Sandroni, Paola; Low, Phillip Anson; Joyner, Michael Joseph.

In: Journal of Applied Physiology, Vol. 103, No. 4, 10.2007, p. 1136-1142.

Research output: Contribution to journalArticle

Masuki, S, Eisenach, JH, Schrage, WG, Dietz, NM, Johnson, CP, Wilkins, BW, Dierkhising, RA, Sandroni, P, Low, PA & Joyner, MJ 2007, 'Arterial baroreflex control of heart rate during exercise in postural tachycardia syndrome', Journal of Applied Physiology, vol. 103, no. 4, pp. 1136-1142. https://doi.org/10.1152/japplphysiol.00176.2007
Masuki, Shizue ; Eisenach, John H. ; Schrage, William G. ; Dietz, Niki M. ; Johnson, Christopher P. ; Wilkins, Brad W. ; Dierkhising, Ross A. ; Sandroni, Paola ; Low, Phillip Anson ; Joyner, Michael Joseph. / Arterial baroreflex control of heart rate during exercise in postural tachycardia syndrome. In: Journal of Applied Physiology. 2007 ; Vol. 103, No. 4. pp. 1136-1142.
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abstract = "Patients with postural tachycardia syndrome (POTS) have excessive tachycardia without hypotension during orthostasis as well as exercise. We tested the hypothesis that excessive tachycardia during exercise in POTS is not related to abnormal baroreflex control of heart rate (HR). Patients (n = 13) and healthy controls (n = 10) performed graded cycle exercise at 25, 50, and 75 W in both supine and upright positions while arterial pressure (arterial catheter) and HR (ECG) were measured. Baroreflex sensitivity of HR was assessed by bolus intravenous infusion of phenylephrine at each workload. In both positions, HR was higher in the patients than the controls during exercise. Supine baroreflex sensitivity (HR/systolic pressure) in POTS patients was -1.3 ± 0.1 beats·min-1·mmHg-1 at rest and decreased to -0.6 ± 0.1 beats·min-1·mmHg-1 during 75-W exercise, neither significantly different from the controls (P > 0.6). In the upright position, baroreflex sensitivity in POTS patients at rest (-1.4 ± 0.1 beats·min-1·mmHg-1) was higher than the controls (-1.0 ± 0.1 beats·min -1·mmHg-1) (P · 0.05), and it decreased to -0.1 ± 0.04 beats·min-1·mmHg-1 during 75-W exercise, lower than the controls (-0.3 ± 0.09 beats· min-1·mmHg-1) (P < 0.05). The reduced arterial baroreflex sensitivity of HR during upright exercise was accompanied by greater fluctuations in systolic and pulse pressure in the patients than in the controls with 56 and 90{\%} higher coefficient of variations, respectively (P < 0.01). However, when baroreflex control of HR was corrected for differences in HR, it was similar between the patients and controls during upright exercise. These results suggest that the tachycardia during exercise in POTS was not due to abnormal baroreflex control of HR.",
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