Abstract
We used BAC array-based CGH to detect genomic imbalances in 187 CLL cases. Submicroscopic deletions of chromosome 22q11 were observed in 28 cases (15%), and the frequency of these deletions was second only to loss of the 13q14 region, the most common genomic aberration in CLL. Oligonucleotide-based array CGH analysis showed that the 22q11 deletions ranged in size from 0.34 Mb up to ∼1 Mb. The minimally deleted region included the ZNF280A, ZNF280B, GGTLC2, and PRAME genes. Quantitative real-time PCR revealed that ZNF280A, ZNF280B, and PRAME mRNA expression was significantly lower in the 22q11 deletion cases compared to non-deleted cases.
Original language | English (US) |
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Pages (from-to) | 1276-1281 |
Number of pages | 6 |
Journal | Leukemia Research |
Volume | 33 |
Issue number | 9 |
DOIs | |
State | Published - Sep 2009 |
Keywords
- Array CGH
- Chromosome 22q11
- Chronic lymphocytic leukemia
- PRAME gene
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research