ARID2: A new tumor suppressor gene in hepatocellular carcinoma

Hong Zhao, Jian Wang, Yongqing Han, Zhen Huang, Jianming Ying, Xinyu Bi, Jianjun Zhao, Yi Fang, Haitao Zhou, Jianguo Zhou, Zhiyu Li, Yefan Zhang, Xue Yang, Tao Yan, Linfang Wang, Michael S. Torbenson, Jianqiang Cai

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, however, genetic-environmental interactions and mechanisms associated with the development of HCC remains largely unclear. Our recent work described novel inactivating mutations of ARID2 (AT-rich interactive domain 2) in four major subtypes of HCC through exomic sequencing of ten HCV-associated HCCs and subsequent evaluation of the tumors from additional affected individuals. Here, we summarize the current knowledge about the relevance of ARID2 in HCC and the implication in future patient care.

Original languageEnglish (US)
Pages (from-to)886-891
Number of pages6
JournalOncotarget
Volume2
Issue number11
DOIs
StatePublished - Nov 2011

Keywords

  • ARID2
  • Hepatitis C virus
  • Hepatocellular carcinoma
  • Interferon
  • Tumor suppressor

ASJC Scopus subject areas

  • Oncology

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  • Cite this

    Zhao, H., Wang, J., Han, Y., Huang, Z., Ying, J., Bi, X., Zhao, J., Fang, Y., Zhou, H., Zhou, J., Li, Z., Zhang, Y., Yang, X., Yan, T., Wang, L., Torbenson, M. S., & Cai, J. (2011). ARID2: A new tumor suppressor gene in hepatocellular carcinoma. Oncotarget, 2(11), 886-891. https://doi.org/10.18632/oncotarget.355