ARID2: A new tumor suppressor gene in hepatocellular carcinoma

Hong Zhao; Jian Wang; Yongqing Han; Zhen Huang; Jianming Ying; Xinyu Bi; Jianjun Zhao; Yi Fang; Haitao Zhou; Jianguo Zhou; Zhiyu Li; Yefan Zhang; Xue Yang; Tao Yan; Linfang Wang; Michael S. Torbenson; Jianqiang Cai

doi:10.18632/oncotarget.355

ARID2: A new tumor suppressor gene in hepatocellular carcinoma

Hong Zhao, Jian Wang, Yongqing Han, Zhen Huang, Jianming Ying, Xinyu Bi, Jianjun Zhao, Yi Fang, Haitao Zhou, Jianguo Zhou, Zhiyu Li, Yefan Zhang, Xue Yang, Tao Yan, Linfang Wang, Michael S. Torbenson, Jianqiang Cai

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, however, genetic-environmental interactions and mechanisms associated with the development of HCC remains largely unclear. Our recent work described novel inactivating mutations of ARID2 (AT-rich interactive domain 2) in four major subtypes of HCC through exomic sequencing of ten HCV-associated HCCs and subsequent evaluation of the tumors from additional affected individuals. Here, we summarize the current knowledge about the relevance of ARID2 in HCC and the implication in future patient care.

Original language	English (US)
Pages (from-to)	886-891
Number of pages	6
Journal	Oncotarget
Volume	2
Issue number	11
DOIs	https://doi.org/10.18632/oncotarget.355
State	Published - Nov 2011

Keywords

ARID2
Hepatitis C virus
Hepatocellular carcinoma
Interferon
Tumor suppressor

ASJC Scopus subject areas

Oncology

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10.18632/oncotarget.355

Cite this

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title = "ARID2: A new tumor suppressor gene in hepatocellular carcinoma",

abstract = "Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, however, genetic-environmental interactions and mechanisms associated with the development of HCC remains largely unclear. Our recent work described novel inactivating mutations of ARID2 (AT-rich interactive domain 2) in four major subtypes of HCC through exomic sequencing of ten HCV-associated HCCs and subsequent evaluation of the tumors from additional affected individuals. Here, we summarize the current knowledge about the relevance of ARID2 in HCC and the implication in future patient care.",

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author = "Hong Zhao and Jian Wang and Yongqing Han and Zhen Huang and Jianming Ying and Xinyu Bi and Jianjun Zhao and Yi Fang and Haitao Zhou and Jianguo Zhou and Zhiyu Li and Yefan Zhang and Xue Yang and Tao Yan and Linfang Wang and Torbenson, {Michael S.} and Jianqiang Cai",

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doi = "10.18632/oncotarget.355",

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T1 - ARID2

T2 - A new tumor suppressor gene in hepatocellular carcinoma

AU - Zhao, Hong

AU - Wang, Jian

AU - Han, Yongqing

AU - Huang, Zhen

AU - Ying, Jianming

AU - Bi, Xinyu

AU - Zhao, Jianjun

AU - Fang, Yi

AU - Zhou, Haitao

AU - Zhou, Jianguo

AU - Li, Zhiyu

AU - Zhang, Yefan

AU - Yang, Xue

AU - Yan, Tao

AU - Wang, Linfang

AU - Torbenson, Michael S.

AU - Cai, Jianqiang

PY - 2011/11

Y1 - 2011/11

N2 - Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, however, genetic-environmental interactions and mechanisms associated with the development of HCC remains largely unclear. Our recent work described novel inactivating mutations of ARID2 (AT-rich interactive domain 2) in four major subtypes of HCC through exomic sequencing of ten HCV-associated HCCs and subsequent evaluation of the tumors from additional affected individuals. Here, we summarize the current knowledge about the relevance of ARID2 in HCC and the implication in future patient care.

AB - Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, however, genetic-environmental interactions and mechanisms associated with the development of HCC remains largely unclear. Our recent work described novel inactivating mutations of ARID2 (AT-rich interactive domain 2) in four major subtypes of HCC through exomic sequencing of ten HCV-associated HCCs and subsequent evaluation of the tumors from additional affected individuals. Here, we summarize the current knowledge about the relevance of ARID2 in HCC and the implication in future patient care.

KW - ARID2

KW - Hepatitis C virus

KW - Hepatocellular carcinoma

KW - Interferon

KW - Tumor suppressor

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ARID2: A new tumor suppressor gene in hepatocellular carcinoma

Abstract

Keywords

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