Arial fibrillation in patients with chronic lymphocytic leukemia (CLL)

Tait D. Shanafelt, Sameer A Parikh, Peter Noseworthy, Valentin Goede, Kari G. Chaffee, Jasmin Bahlo, Timothy G. Call, Susan M. Schwager, Wei D Ding, Barbara Eichhorst, Kirsten Fischer, Jose F. Leis, Asher A Chanan Khan, Michael Hallek, Susan L Slager, Neil Elliot Kay

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39 Scopus citations

Abstract

Although preliminary data suggests that ibrutinib may increase risk of atrial fibrillation (AF), the incidence of AF in a general cohort of chronic lymphocytic leukemia (CLL) patients is unknown. We evaluated the prevalence of AF at CLL diagnosis and incidence of AF during follow-up in 2444 patients with newly diagnosed CLL. A prior history of AF was present at CLL diagnosis in 148 (6.1%). Among the 2292 patients without history of AF, 139 (6.1%) developed incident AF during follow-up (incidence approximately 1%/year). Older age (p < .0001), male sex (p = .01), valvular heart disease (p = .001), and hypertension (p = .04) were associated with risk of incident AF on multivariate analysis. A predictive model for developing incident AF constructed from these factors stratified patients into 4 groups with 10-year rates of incident AF ranging from 4% to 33% (p < .0001). This information provides context for interpreting rates of AF in CLL patients treated with novel therapies.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalLeukemia and Lymphoma
DOIs
StateAccepted/In press - Nov 24 2016

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Keywords

  • atrial fibrillation
  • Chronic lymphocytic leukemia
  • ibrutinib
  • risk factors

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Shanafelt, T. D., Parikh, S. A., Noseworthy, P., Goede, V., Chaffee, K. G., Bahlo, J., Call, T. G., Schwager, S. M., Ding, W. D., Eichhorst, B., Fischer, K., Leis, J. F., Chanan Khan, A. A., Hallek, M., Slager, S. L., & Kay, N. E. (Accepted/In press). Arial fibrillation in patients with chronic lymphocytic leukemia (CLL). Leukemia and Lymphoma, 1-10. https://doi.org/10.1080/10428194.2016.1257795