Abstract

Background: Argyrophilic grains (AG) are silver-positive spindle-shaped lesions found at postmortem. Their significance is controversial. Objective: To determine clinical correlates of AG and MRI patterns of atrophy that could allow premortem recognition of this pathology. Methods: Cases with AG were identified from a longitudinal study of aging and dementia. Clinical features were compared between subjects with and without dementia. Voxel-based morphometry (VBM) was used to assess patterns of grey matter atrophy in subjects compared to controls. Whole brain volumes (WBV) were compared across groups. Results: Twenty-two cases (14 females; median age at death of 90 years; range: 70-101) with AG were identified. Eight of the 22 were demented. Those with dementia had higher Braak (p = 0.02) and lower Mini-Mental State Examination (MMSE) (p = 0.002). VBM demonstrated hippocampal atrophy in those with dementia (N = 3) but no atrophy in those without (N = 9). There was no difference in WBV between groups. Conclusion: AG is a feature of old age commonly occurring in non-demented subjects. In this age group, the presence of AG may reduce the threshold for dementia.

Original languageEnglish (US)
Pages (from-to)566-573
Number of pages8
JournalNeurobiology of Aging
Volume29
Issue number4
DOIs
StatePublished - Apr 2008

Fingerprint

Dementia
Atrophy
Pathology
Brain
Silver
Longitudinal Studies
Age Groups

Keywords

  • Alzheimer's disease
  • Argyrophilic
  • MRI
  • Total intracranial volume
  • Volume loss
  • Voxel-based morphometry

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

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title = "Argyrophilic grains: A distinct disease or an additive pathology?",
abstract = "Background: Argyrophilic grains (AG) are silver-positive spindle-shaped lesions found at postmortem. Their significance is controversial. Objective: To determine clinical correlates of AG and MRI patterns of atrophy that could allow premortem recognition of this pathology. Methods: Cases with AG were identified from a longitudinal study of aging and dementia. Clinical features were compared between subjects with and without dementia. Voxel-based morphometry (VBM) was used to assess patterns of grey matter atrophy in subjects compared to controls. Whole brain volumes (WBV) were compared across groups. Results: Twenty-two cases (14 females; median age at death of 90 years; range: 70-101) with AG were identified. Eight of the 22 were demented. Those with dementia had higher Braak (p = 0.02) and lower Mini-Mental State Examination (MMSE) (p = 0.002). VBM demonstrated hippocampal atrophy in those with dementia (N = 3) but no atrophy in those without (N = 9). There was no difference in WBV between groups. Conclusion: AG is a feature of old age commonly occurring in non-demented subjects. In this age group, the presence of AG may reduce the threshold for dementia.",
keywords = "Alzheimer's disease, Argyrophilic, MRI, Total intracranial volume, Volume loss, Voxel-based morphometry",
author = "Josephs, {Keith Anthony} and Whitwell, {Jennifer Lynn} and Parisi, {Joseph E} and Knopman, {David S} and Boeve, {Bradley F} and Geda, {Yonas Endale} and Jack, {Clifford R Jr.} and Petersen, {Ronald Carl} and Dickson, {Dennis W}",
year = "2008",
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doi = "10.1016/j.neurobiolaging.2006.10.032",
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pages = "566--573",
journal = "Neurobiology of Aging",
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TY - JOUR

T1 - Argyrophilic grains

T2 - A distinct disease or an additive pathology?

AU - Josephs, Keith Anthony

AU - Whitwell, Jennifer Lynn

AU - Parisi, Joseph E

AU - Knopman, David S

AU - Boeve, Bradley F

AU - Geda, Yonas Endale

AU - Jack, Clifford R Jr.

AU - Petersen, Ronald Carl

AU - Dickson, Dennis W

PY - 2008/4

Y1 - 2008/4

N2 - Background: Argyrophilic grains (AG) are silver-positive spindle-shaped lesions found at postmortem. Their significance is controversial. Objective: To determine clinical correlates of AG and MRI patterns of atrophy that could allow premortem recognition of this pathology. Methods: Cases with AG were identified from a longitudinal study of aging and dementia. Clinical features were compared between subjects with and without dementia. Voxel-based morphometry (VBM) was used to assess patterns of grey matter atrophy in subjects compared to controls. Whole brain volumes (WBV) were compared across groups. Results: Twenty-two cases (14 females; median age at death of 90 years; range: 70-101) with AG were identified. Eight of the 22 were demented. Those with dementia had higher Braak (p = 0.02) and lower Mini-Mental State Examination (MMSE) (p = 0.002). VBM demonstrated hippocampal atrophy in those with dementia (N = 3) but no atrophy in those without (N = 9). There was no difference in WBV between groups. Conclusion: AG is a feature of old age commonly occurring in non-demented subjects. In this age group, the presence of AG may reduce the threshold for dementia.

AB - Background: Argyrophilic grains (AG) are silver-positive spindle-shaped lesions found at postmortem. Their significance is controversial. Objective: To determine clinical correlates of AG and MRI patterns of atrophy that could allow premortem recognition of this pathology. Methods: Cases with AG were identified from a longitudinal study of aging and dementia. Clinical features were compared between subjects with and without dementia. Voxel-based morphometry (VBM) was used to assess patterns of grey matter atrophy in subjects compared to controls. Whole brain volumes (WBV) were compared across groups. Results: Twenty-two cases (14 females; median age at death of 90 years; range: 70-101) with AG were identified. Eight of the 22 were demented. Those with dementia had higher Braak (p = 0.02) and lower Mini-Mental State Examination (MMSE) (p = 0.002). VBM demonstrated hippocampal atrophy in those with dementia (N = 3) but no atrophy in those without (N = 9). There was no difference in WBV between groups. Conclusion: AG is a feature of old age commonly occurring in non-demented subjects. In this age group, the presence of AG may reduce the threshold for dementia.

KW - Alzheimer's disease

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KW - Total intracranial volume

KW - Volume loss

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