Are ultrasound renal aspects associated with urinary biochemistry in fetuses with lower urinary tract obstruction?

Ahmed A. Nassr, Chester Koh Koh, Alireza A. Shamshirsaz, Jimmy Espinoza, Haleh Sangi-Haghpeykar, Dina Sharhan, Stephen Welty, Joseph Angelo, David Roth, Michael A. Belfort, Michael Braun, Rodrigo Ruano

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: To evaluate the association between ultrasonographic renal parameters and urine biochemistry in fetuses with lower urinary tract obstruction (LUTO). Methods: Data were collected prospectively from 31 consecutive fetuses with LUTO that underwent vesicocentesis for fetal urinary biochemistry between April 2013 and September 2015. The following renal ultrasound markers were assessed immediately before the vesicocentesis: renal echogenicity, presence of cortical cysts, presence of findings suggestive of ‘renal dysplasia’ (hyperechogenic cystic kidneys with no cortical-medullary differentiation) and severe oligohydramnios (amniotic fluid < 5th percentile). The association of these parameters to the fetal urinary concentration of sodium, chloride, calcium, osmolality and beta2-microglobulin was investigated by logistic regression analysis. Results: There was no relationship between any of the ultrasonographic fetal renal characteristics and fetal urinary biochemistry. Conclusions: In LUTO, the ultrasound appearance of the fetal kidneys and urinary biochemistry are not correlated. It may be better to take both ultrasound and biochemistry into account when evaluating fetuses with fetal LUTO.

Original languageEnglish (US)
Pages (from-to)1206-1210
Number of pages5
JournalPrenatal Diagnosis
Volume36
Issue number13
DOIs
StatePublished - Dec 1 2016

Fingerprint

Urinary Tract
Biochemistry
Fetus
Kidney
Oligohydramnios
Cystic Kidney Diseases
Amniotic Fluid
Sodium Chloride
Osmolar Concentration
Cysts
Logistic Models
Regression Analysis
Urine
Calcium

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Genetics(clinical)

Cite this

Nassr, A. A., Koh, C. K., Shamshirsaz, A. A., Espinoza, J., Sangi-Haghpeykar, H., Sharhan, D., ... Ruano, R. (2016). Are ultrasound renal aspects associated with urinary biochemistry in fetuses with lower urinary tract obstruction? Prenatal Diagnosis, 36(13), 1206-1210. https://doi.org/10.1002/pd.4958

Are ultrasound renal aspects associated with urinary biochemistry in fetuses with lower urinary tract obstruction? / Nassr, Ahmed A.; Koh, Chester Koh; Shamshirsaz, Alireza A.; Espinoza, Jimmy; Sangi-Haghpeykar, Haleh; Sharhan, Dina; Welty, Stephen; Angelo, Joseph; Roth, David; Belfort, Michael A.; Braun, Michael; Ruano, Rodrigo.

In: Prenatal Diagnosis, Vol. 36, No. 13, 01.12.2016, p. 1206-1210.

Research output: Contribution to journalArticle

Nassr, AA, Koh, CK, Shamshirsaz, AA, Espinoza, J, Sangi-Haghpeykar, H, Sharhan, D, Welty, S, Angelo, J, Roth, D, Belfort, MA, Braun, M & Ruano, R 2016, 'Are ultrasound renal aspects associated with urinary biochemistry in fetuses with lower urinary tract obstruction?', Prenatal Diagnosis, vol. 36, no. 13, pp. 1206-1210. https://doi.org/10.1002/pd.4958
Nassr AA, Koh CK, Shamshirsaz AA, Espinoza J, Sangi-Haghpeykar H, Sharhan D et al. Are ultrasound renal aspects associated with urinary biochemistry in fetuses with lower urinary tract obstruction? Prenatal Diagnosis. 2016 Dec 1;36(13):1206-1210. https://doi.org/10.1002/pd.4958
Nassr, Ahmed A. ; Koh, Chester Koh ; Shamshirsaz, Alireza A. ; Espinoza, Jimmy ; Sangi-Haghpeykar, Haleh ; Sharhan, Dina ; Welty, Stephen ; Angelo, Joseph ; Roth, David ; Belfort, Michael A. ; Braun, Michael ; Ruano, Rodrigo. / Are ultrasound renal aspects associated with urinary biochemistry in fetuses with lower urinary tract obstruction?. In: Prenatal Diagnosis. 2016 ; Vol. 36, No. 13. pp. 1206-1210.
@article{5ad1d5c475994c908b9121bb08fea469,
title = "Are ultrasound renal aspects associated with urinary biochemistry in fetuses with lower urinary tract obstruction?",
abstract = "Objective: To evaluate the association between ultrasonographic renal parameters and urine biochemistry in fetuses with lower urinary tract obstruction (LUTO). Methods: Data were collected prospectively from 31 consecutive fetuses with LUTO that underwent vesicocentesis for fetal urinary biochemistry between April 2013 and September 2015. The following renal ultrasound markers were assessed immediately before the vesicocentesis: renal echogenicity, presence of cortical cysts, presence of findings suggestive of ‘renal dysplasia’ (hyperechogenic cystic kidneys with no cortical-medullary differentiation) and severe oligohydramnios (amniotic fluid < 5th percentile). The association of these parameters to the fetal urinary concentration of sodium, chloride, calcium, osmolality and beta2-microglobulin was investigated by logistic regression analysis. Results: There was no relationship between any of the ultrasonographic fetal renal characteristics and fetal urinary biochemistry. Conclusions: In LUTO, the ultrasound appearance of the fetal kidneys and urinary biochemistry are not correlated. It may be better to take both ultrasound and biochemistry into account when evaluating fetuses with fetal LUTO.",
author = "Nassr, {Ahmed A.} and Koh, {Chester Koh} and Shamshirsaz, {Alireza A.} and Jimmy Espinoza and Haleh Sangi-Haghpeykar and Dina Sharhan and Stephen Welty and Joseph Angelo and David Roth and Belfort, {Michael A.} and Michael Braun and Rodrigo Ruano",
year = "2016",
month = "12",
day = "1",
doi = "10.1002/pd.4958",
language = "English (US)",
volume = "36",
pages = "1206--1210",
journal = "Prenatal Diagnosis",
issn = "0197-3851",
publisher = "John Wiley and Sons Ltd",
number = "13",

}

TY - JOUR

T1 - Are ultrasound renal aspects associated with urinary biochemistry in fetuses with lower urinary tract obstruction?

AU - Nassr, Ahmed A.

AU - Koh, Chester Koh

AU - Shamshirsaz, Alireza A.

AU - Espinoza, Jimmy

AU - Sangi-Haghpeykar, Haleh

AU - Sharhan, Dina

AU - Welty, Stephen

AU - Angelo, Joseph

AU - Roth, David

AU - Belfort, Michael A.

AU - Braun, Michael

AU - Ruano, Rodrigo

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Objective: To evaluate the association between ultrasonographic renal parameters and urine biochemistry in fetuses with lower urinary tract obstruction (LUTO). Methods: Data were collected prospectively from 31 consecutive fetuses with LUTO that underwent vesicocentesis for fetal urinary biochemistry between April 2013 and September 2015. The following renal ultrasound markers were assessed immediately before the vesicocentesis: renal echogenicity, presence of cortical cysts, presence of findings suggestive of ‘renal dysplasia’ (hyperechogenic cystic kidneys with no cortical-medullary differentiation) and severe oligohydramnios (amniotic fluid < 5th percentile). The association of these parameters to the fetal urinary concentration of sodium, chloride, calcium, osmolality and beta2-microglobulin was investigated by logistic regression analysis. Results: There was no relationship between any of the ultrasonographic fetal renal characteristics and fetal urinary biochemistry. Conclusions: In LUTO, the ultrasound appearance of the fetal kidneys and urinary biochemistry are not correlated. It may be better to take both ultrasound and biochemistry into account when evaluating fetuses with fetal LUTO.

AB - Objective: To evaluate the association between ultrasonographic renal parameters and urine biochemistry in fetuses with lower urinary tract obstruction (LUTO). Methods: Data were collected prospectively from 31 consecutive fetuses with LUTO that underwent vesicocentesis for fetal urinary biochemistry between April 2013 and September 2015. The following renal ultrasound markers were assessed immediately before the vesicocentesis: renal echogenicity, presence of cortical cysts, presence of findings suggestive of ‘renal dysplasia’ (hyperechogenic cystic kidneys with no cortical-medullary differentiation) and severe oligohydramnios (amniotic fluid < 5th percentile). The association of these parameters to the fetal urinary concentration of sodium, chloride, calcium, osmolality and beta2-microglobulin was investigated by logistic regression analysis. Results: There was no relationship between any of the ultrasonographic fetal renal characteristics and fetal urinary biochemistry. Conclusions: In LUTO, the ultrasound appearance of the fetal kidneys and urinary biochemistry are not correlated. It may be better to take both ultrasound and biochemistry into account when evaluating fetuses with fetal LUTO.

UR - http://www.scopus.com/inward/record.url?scp=85006410505&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85006410505&partnerID=8YFLogxK

U2 - 10.1002/pd.4958

DO - 10.1002/pd.4958

M3 - Article

C2 - 27862070

AN - SCOPUS:85006410505

VL - 36

SP - 1206

EP - 1210

JO - Prenatal Diagnosis

JF - Prenatal Diagnosis

SN - 0197-3851

IS - 13

ER -