Gibt es unterschiedliche überlebensraten für jüngere und ältere patienten mit rektumkarzinom?

Translated title of the contribution: Are survival rates different for young and older patients with rectal cancer?

Jessica B. O'Connell, Melinda A. Maggard, Jerome H. Liu, David A. Etzioni, Clifford Y. Ko

Research output: Contribution to journalArticle

Abstract

Purpose: Although it is generally believed that young patients with rectal cancer have worse survival rates, no comprehensive analysis has been reported. This study uses a national-level, population-based cancer registry to compare rectal cancer outcomes between young vs. older populations. Methods: All patients with rectal carcinoma in the Surveillance, Epidemiology, and End Results cancer database from 1991-1999 were evaluated. Young (range, 20-40 years; n = 466) and older groups (range, 60-80 years; n = 11,312) were compared for patient and tumor characteristics, treatment patterns, and five-year overall and stage-specific survival. Cox multivariate regression analysis was performed to identify predictors of survival. Results: Mean ages for the groups were 34.1 and 70 years. The young group was comprised of more black and Hispanic patients compared with the older group (p < 0.001). Young patients were more likely to present with late-stage disease (young vs. older: Stage III, 27 vs. 20% respectively, p < 0.001; Stage IV, 17.4 vs. 13.6% respectively, p < 0.02). The younger group also had worse grade tumors (poorly differentiated 24.3 vs. 14% respectively, p < 0.001). Although the majority of both groups received surgery (85% for each), significantly more young patients received radiation (p < 0.001). Importantly, overall and stage-specific, five-year survival rates were similar for both groups (p = not significant). Conclusions: Although previous studies have found young rectal cancer patients to have poorer survival compared with older patients, this population-based study shows that young rectal cancer patients seem to have equivalent overall and stage-specific survival.

Original languageGerman
Pages (from-to)335-342
Number of pages8
JournalColoproctology
Volume27
Issue number6
DOIs
StatePublished - Dec 2005
Externally publishedYes

Fingerprint

Rectal Neoplasms
Survival Rate
Survival
Neoplasms
Population
Hispanic Americans
Registries
Epidemiology
Multivariate Analysis
Age Groups
Regression Analysis
Databases
Radiation
Carcinoma

Keywords

  • Cancer
  • Population-based
  • Rectal
  • SEER
  • Survival
  • Young

ASJC Scopus subject areas

  • Gastroenterology
  • Surgery

Cite this

Gibt es unterschiedliche überlebensraten für jüngere und ältere patienten mit rektumkarzinom? / O'Connell, Jessica B.; Maggard, Melinda A.; Liu, Jerome H.; Etzioni, David A.; Ko, Clifford Y.

In: Coloproctology, Vol. 27, No. 6, 12.2005, p. 335-342.

Research output: Contribution to journalArticle

O'Connell, Jessica B. ; Maggard, Melinda A. ; Liu, Jerome H. ; Etzioni, David A. ; Ko, Clifford Y. / Gibt es unterschiedliche überlebensraten für jüngere und ältere patienten mit rektumkarzinom?. In: Coloproctology. 2005 ; Vol. 27, No. 6. pp. 335-342.
@article{9fcdcc974bd04c4e80e262f7d63b38c4,
title = "Gibt es unterschiedliche {\"u}berlebensraten f{\"u}r j{\"u}ngere und {\"a}ltere patienten mit rektumkarzinom?",
abstract = "Purpose: Although it is generally believed that young patients with rectal cancer have worse survival rates, no comprehensive analysis has been reported. This study uses a national-level, population-based cancer registry to compare rectal cancer outcomes between young vs. older populations. Methods: All patients with rectal carcinoma in the Surveillance, Epidemiology, and End Results cancer database from 1991-1999 were evaluated. Young (range, 20-40 years; n = 466) and older groups (range, 60-80 years; n = 11,312) were compared for patient and tumor characteristics, treatment patterns, and five-year overall and stage-specific survival. Cox multivariate regression analysis was performed to identify predictors of survival. Results: Mean ages for the groups were 34.1 and 70 years. The young group was comprised of more black and Hispanic patients compared with the older group (p < 0.001). Young patients were more likely to present with late-stage disease (young vs. older: Stage III, 27 vs. 20{\%} respectively, p < 0.001; Stage IV, 17.4 vs. 13.6{\%} respectively, p < 0.02). The younger group also had worse grade tumors (poorly differentiated 24.3 vs. 14{\%} respectively, p < 0.001). Although the majority of both groups received surgery (85{\%} for each), significantly more young patients received radiation (p < 0.001). Importantly, overall and stage-specific, five-year survival rates were similar for both groups (p = not significant). Conclusions: Although previous studies have found young rectal cancer patients to have poorer survival compared with older patients, this population-based study shows that young rectal cancer patients seem to have equivalent overall and stage-specific survival.",
keywords = "Cancer, Population-based, Rectal, SEER, Survival, Young",
author = "O'Connell, {Jessica B.} and Maggard, {Melinda A.} and Liu, {Jerome H.} and Etzioni, {David A.} and Ko, {Clifford Y.}",
year = "2005",
month = "12",
doi = "10.1007/s00053-005-5165-0",
language = "German",
volume = "27",
pages = "335--342",
journal = "Coloproctology",
issn = "0174-2442",
publisher = "Urban und Vogel",
number = "6",

}

TY - JOUR

T1 - Gibt es unterschiedliche überlebensraten für jüngere und ältere patienten mit rektumkarzinom?

AU - O'Connell, Jessica B.

AU - Maggard, Melinda A.

AU - Liu, Jerome H.

AU - Etzioni, David A.

AU - Ko, Clifford Y.

PY - 2005/12

Y1 - 2005/12

N2 - Purpose: Although it is generally believed that young patients with rectal cancer have worse survival rates, no comprehensive analysis has been reported. This study uses a national-level, population-based cancer registry to compare rectal cancer outcomes between young vs. older populations. Methods: All patients with rectal carcinoma in the Surveillance, Epidemiology, and End Results cancer database from 1991-1999 were evaluated. Young (range, 20-40 years; n = 466) and older groups (range, 60-80 years; n = 11,312) were compared for patient and tumor characteristics, treatment patterns, and five-year overall and stage-specific survival. Cox multivariate regression analysis was performed to identify predictors of survival. Results: Mean ages for the groups were 34.1 and 70 years. The young group was comprised of more black and Hispanic patients compared with the older group (p < 0.001). Young patients were more likely to present with late-stage disease (young vs. older: Stage III, 27 vs. 20% respectively, p < 0.001; Stage IV, 17.4 vs. 13.6% respectively, p < 0.02). The younger group also had worse grade tumors (poorly differentiated 24.3 vs. 14% respectively, p < 0.001). Although the majority of both groups received surgery (85% for each), significantly more young patients received radiation (p < 0.001). Importantly, overall and stage-specific, five-year survival rates were similar for both groups (p = not significant). Conclusions: Although previous studies have found young rectal cancer patients to have poorer survival compared with older patients, this population-based study shows that young rectal cancer patients seem to have equivalent overall and stage-specific survival.

AB - Purpose: Although it is generally believed that young patients with rectal cancer have worse survival rates, no comprehensive analysis has been reported. This study uses a national-level, population-based cancer registry to compare rectal cancer outcomes between young vs. older populations. Methods: All patients with rectal carcinoma in the Surveillance, Epidemiology, and End Results cancer database from 1991-1999 were evaluated. Young (range, 20-40 years; n = 466) and older groups (range, 60-80 years; n = 11,312) were compared for patient and tumor characteristics, treatment patterns, and five-year overall and stage-specific survival. Cox multivariate regression analysis was performed to identify predictors of survival. Results: Mean ages for the groups were 34.1 and 70 years. The young group was comprised of more black and Hispanic patients compared with the older group (p < 0.001). Young patients were more likely to present with late-stage disease (young vs. older: Stage III, 27 vs. 20% respectively, p < 0.001; Stage IV, 17.4 vs. 13.6% respectively, p < 0.02). The younger group also had worse grade tumors (poorly differentiated 24.3 vs. 14% respectively, p < 0.001). Although the majority of both groups received surgery (85% for each), significantly more young patients received radiation (p < 0.001). Importantly, overall and stage-specific, five-year survival rates were similar for both groups (p = not significant). Conclusions: Although previous studies have found young rectal cancer patients to have poorer survival compared with older patients, this population-based study shows that young rectal cancer patients seem to have equivalent overall and stage-specific survival.

KW - Cancer

KW - Population-based

KW - Rectal

KW - SEER

KW - Survival

KW - Young

UR - http://www.scopus.com/inward/record.url?scp=29144487886&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=29144487886&partnerID=8YFLogxK

U2 - 10.1007/s00053-005-5165-0

DO - 10.1007/s00053-005-5165-0

M3 - Article

AN - SCOPUS:29144487886

VL - 27

SP - 335

EP - 342

JO - Coloproctology

JF - Coloproctology

SN - 0174-2442

IS - 6

ER -