Purpose: Although it is generally believed that young patients with rectal cancer have worse survival rates, no comprehensive analysis has been reported. This study uses a national-level, population-based cancer registry to compare rectal cancer outcomes between young vs. older populations. Methods: All patients with rectal carcinoma in the Surveillance, Epidemiology, and End Results cancer database from 1991-1999 were evaluated. Young (range, 20-40 years; n = 466) and older groups (range, 60-80 years; n = 11,312) were compared for patient and tumor characteristics, treatment patterns, and five-year overall and stage-specific survival. Cox multivariate regression analysis was performed to identify predictors of survival. Results: Mean ages for the groups were 34.1 and 70 years. The young group was comprised of more black and Hispanic patients compared with the older group (p < 0.001). Young patients were more likely to present with late-stage disease (young vs. older: Stage III, 27 vs. 20% respectively, p < 0.001; Stage IV, 17.4 vs. 13.6% respectively, p < 0.02). The younger group also had worse grade tumors (poorly differentiated 24.3 vs. 14% respectively, p < 0.001). Although the majority of both groups received surgery (85% for each), significantly more young patients received radiation (p < 0.001). Importantly, overall and stage-specific, five-year survival rates were similar for both groups (p = not significant). Conclusions: Although previous studies have found young rectal cancer patients to have poorer survival compared with older patients, this population-based study shows that young rectal cancer patients seem to have equivalent overall and stage-specific survival.
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