Are phosphatonins relevant in the pathogenesis of nephrolithiasis?

Aisha Shaikh, Rajiv Kumar

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Hypercalciuria is the single most important risk factor for stone disease and renal phosphate excretion is a recognized cause of absorptive hypercalciuria. The recent identification of "phosphatonins" that increase renal phosphate excretion has raised the possibility that these factors might be responsible for the phosphaturia seen in some patients with absorptive hypercalciuria. It is important to recognize that both parathyroid hormone and phosphatonins are phosphaturic, but they have opposite effects on 1,25(OH) 2D3 regulation. Serum concentrations of fibroblast growth factor-23, one of the phosphatonins, have been shown to be increased in some stone formers suggesting a pathogenic role. Future studies are needed to define the exact role of phosphatonins in nephrolithiasis.

Original languageEnglish (US)
Title of host publicationAIP Conference Proceedings
Pages170-175
Number of pages6
Volume900
StatePublished - 2007
Event1st Annual International Urolithiasis Research Symposium - Indianapolis, IN, United States
Duration: Nov 2 2006Nov 3 2006

Other

Other1st Annual International Urolithiasis Research Symposium
CountryUnited States
CityIndianapolis, IN
Period11/2/0611/3/06

Fingerprint

pathogenesis
excretion
phosphates
rocks
hormones
fibroblasts
serums
causes

Keywords

  • Nephrolithiasis
  • Phosphatonins and fibroblast growth factor-23

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Shaikh, A., & Kumar, R. (2007). Are phosphatonins relevant in the pathogenesis of nephrolithiasis? In AIP Conference Proceedings (Vol. 900, pp. 170-175)

Are phosphatonins relevant in the pathogenesis of nephrolithiasis? / Shaikh, Aisha; Kumar, Rajiv.

AIP Conference Proceedings. Vol. 900 2007. p. 170-175.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Shaikh, A & Kumar, R 2007, Are phosphatonins relevant in the pathogenesis of nephrolithiasis? in AIP Conference Proceedings. vol. 900, pp. 170-175, 1st Annual International Urolithiasis Research Symposium, Indianapolis, IN, United States, 11/2/06.
Shaikh A, Kumar R. Are phosphatonins relevant in the pathogenesis of nephrolithiasis? In AIP Conference Proceedings. Vol. 900. 2007. p. 170-175
Shaikh, Aisha ; Kumar, Rajiv. / Are phosphatonins relevant in the pathogenesis of nephrolithiasis?. AIP Conference Proceedings. Vol. 900 2007. pp. 170-175
@inproceedings{c1bcf33866794d138a2557c852e80a0e,
title = "Are phosphatonins relevant in the pathogenesis of nephrolithiasis?",
abstract = "Hypercalciuria is the single most important risk factor for stone disease and renal phosphate excretion is a recognized cause of absorptive hypercalciuria. The recent identification of {"}phosphatonins{"} that increase renal phosphate excretion has raised the possibility that these factors might be responsible for the phosphaturia seen in some patients with absorptive hypercalciuria. It is important to recognize that both parathyroid hormone and phosphatonins are phosphaturic, but they have opposite effects on 1,25(OH) 2D3 regulation. Serum concentrations of fibroblast growth factor-23, one of the phosphatonins, have been shown to be increased in some stone formers suggesting a pathogenic role. Future studies are needed to define the exact role of phosphatonins in nephrolithiasis.",
keywords = "Nephrolithiasis, Phosphatonins and fibroblast growth factor-23",
author = "Aisha Shaikh and Rajiv Kumar",
year = "2007",
language = "English (US)",
isbn = "0735404062",
volume = "900",
pages = "170--175",
booktitle = "AIP Conference Proceedings",

}

TY - GEN

T1 - Are phosphatonins relevant in the pathogenesis of nephrolithiasis?

AU - Shaikh, Aisha

AU - Kumar, Rajiv

PY - 2007

Y1 - 2007

N2 - Hypercalciuria is the single most important risk factor for stone disease and renal phosphate excretion is a recognized cause of absorptive hypercalciuria. The recent identification of "phosphatonins" that increase renal phosphate excretion has raised the possibility that these factors might be responsible for the phosphaturia seen in some patients with absorptive hypercalciuria. It is important to recognize that both parathyroid hormone and phosphatonins are phosphaturic, but they have opposite effects on 1,25(OH) 2D3 regulation. Serum concentrations of fibroblast growth factor-23, one of the phosphatonins, have been shown to be increased in some stone formers suggesting a pathogenic role. Future studies are needed to define the exact role of phosphatonins in nephrolithiasis.

AB - Hypercalciuria is the single most important risk factor for stone disease and renal phosphate excretion is a recognized cause of absorptive hypercalciuria. The recent identification of "phosphatonins" that increase renal phosphate excretion has raised the possibility that these factors might be responsible for the phosphaturia seen in some patients with absorptive hypercalciuria. It is important to recognize that both parathyroid hormone and phosphatonins are phosphaturic, but they have opposite effects on 1,25(OH) 2D3 regulation. Serum concentrations of fibroblast growth factor-23, one of the phosphatonins, have been shown to be increased in some stone formers suggesting a pathogenic role. Future studies are needed to define the exact role of phosphatonins in nephrolithiasis.

KW - Nephrolithiasis

KW - Phosphatonins and fibroblast growth factor-23

UR - http://www.scopus.com/inward/record.url?scp=34248167138&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34248167138&partnerID=8YFLogxK

M3 - Conference contribution

SN - 0735404062

SN - 9780735404069

VL - 900

SP - 170

EP - 175

BT - AIP Conference Proceedings

ER -