TY - JOUR
T1 - Are changes in myocardial integrated backscatter restricted to the ischemic zone in acute induced ischemia? An in vivo, animal study
AU - Bijnens, Bart
AU - D'hooge, Jan
AU - Schrooten, Maarten
AU - Pislaru, Sorin
AU - Pislaru, Cristina
AU - De Man, Bruno
AU - Nuyts, Johan
AU - Suetens, Paul
AU - Van de Werf, Frans
AU - Sutherland, George R.
AU - Herregods, Marie Christine
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2000
Y1 - 2000
N2 - Integrated backscatetr (IB) from a myocardial region, calculated from radiofrequency echocardiographic data, has been proposed as a useful parameter for investigating changes in myocardial tissue induced by ischemia. In 10 closed-chest dogs, 5 minutes of myocardial ischemia was induced by either a proximal occlusion of the circumflex coronary artery (CX) (5 dogs), resulting in extensive ischemia in the posterior wall, or by occluding the distal CX vessel (5 dogs) to produce a small localized ischemic zone in the posterior wall. High-resolution digital radiofrequency data from the whole left ventricular myocardium, in the imaging plane during one complete heart cycle, were acquired with a whole-image real-time acquisition approach. Regions in the septum and posterior wall (both ischemic tissue and, in the case of distal occlusions, tissue surrounding the ischemic zone) were chosen for analysis, and IB and cyclic variation (CV) of IB were calculated. Post occlusion, an increase in mean IB values was found in the ischemic segment. However, an increase in CV was also observed in the peri-ischemic zone for the distal CX occlusion and in the septum after proximal CX occlusion. These findings show that changes in CV are not restricted to the ischemic zone but may also occur in distal myocardium. This may be explained by changes in the regional contractile state axed load g conditions of the 'normal' myocardium, which are altered in response to thee distal ischemia.
AB - Integrated backscatetr (IB) from a myocardial region, calculated from radiofrequency echocardiographic data, has been proposed as a useful parameter for investigating changes in myocardial tissue induced by ischemia. In 10 closed-chest dogs, 5 minutes of myocardial ischemia was induced by either a proximal occlusion of the circumflex coronary artery (CX) (5 dogs), resulting in extensive ischemia in the posterior wall, or by occluding the distal CX vessel (5 dogs) to produce a small localized ischemic zone in the posterior wall. High-resolution digital radiofrequency data from the whole left ventricular myocardium, in the imaging plane during one complete heart cycle, were acquired with a whole-image real-time acquisition approach. Regions in the septum and posterior wall (both ischemic tissue and, in the case of distal occlusions, tissue surrounding the ischemic zone) were chosen for analysis, and IB and cyclic variation (CV) of IB were calculated. Post occlusion, an increase in mean IB values was found in the ischemic segment. However, an increase in CV was also observed in the peri-ischemic zone for the distal CX occlusion and in the septum after proximal CX occlusion. These findings show that changes in CV are not restricted to the ischemic zone but may also occur in distal myocardium. This may be explained by changes in the regional contractile state axed load g conditions of the 'normal' myocardium, which are altered in response to thee distal ischemia.
UR - http://www.scopus.com/inward/record.url?scp=0033999763&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033999763&partnerID=8YFLogxK
U2 - 10.1067/mje.2000.103595
DO - 10.1067/mje.2000.103595
M3 - Article
C2 - 10756249
AN - SCOPUS:0033999763
SN - 0894-7317
VL - 13
SP - 306
EP - 315
JO - Journal of the American Society of Echocardiography
JF - Journal of the American Society of Echocardiography
IS - 4
ER -