Are animal models of vasculitis suitable tools?

Research output: Contribution to journalReview article

24 Scopus citations

Abstract

Several rodent models have been proposed for various forms of systemic vasculitis. The MRL-Ipr mouse has been studied extensively as a model for systemic lupus erythematosus. Backcross experiments in combination with genetic linkage studies have firmly established that the phenotype of autoimmune disease is dependent on the combination of various background genes. It has also become apparent that environmental factors, particularly infections, modulate the disease phenotype. Specific interventions, such as the treatment of Brown Norway rats with agents resulting in polyclonal B cell stimulation or immunization with human myeloperoxidase and subsequent localized perfusion with neutrophil lysosomal extract and H2O2, have provided substantial insights into the cellular and molecular mechanisms leading to the development of vasculitis and glomerulonephritis. Even though the existing models may not exactly mirror any specific human disease, they offer reproducible, highly controlled conditions to answer specific questions about pathogenesis and novel therapeutic approaches.

Original languageEnglish (US)
Pages (from-to)11-19
Number of pages9
JournalCurrent opinion in rheumatology
Volume12
Issue number1
DOIs
StatePublished - Jan 19 2000

ASJC Scopus subject areas

  • Rheumatology

Fingerprint Dive into the research topics of 'Are animal models of vasculitis suitable tools?'. Together they form a unique fingerprint.

  • Cite this