Architectural overlap between benign endocervix and pattern-A endocervical adenocarcinoma: Are all pattern-A tumors invasive?

Gregory Douglas, Brooke E. Howitt, J. Kenneth Schoolmeester, Lauren Schwartz, Zuzana Kos, Shahidul Islam, Bojana Djordjevic, Carlos Parra-Herran

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Studies on the pattern-based classification for invasive endocervical adenocarcinoma showed that tumors with nondestructive invasion (pattern-A) have a 0% rate of nodal metastases. Our understanding of pattern-A tumors and their distinction from in-situ adenocarcinoma requires further study. Thirteen sections diagnosed independently as pattern-A adenocarcinoma by three gynecologic pathologists, and 14 sections of benign endocervix were selected. Three additional pathologists (reviewers) evaluated a digital image from each section and classified it as pattern-A or benign based on architecture only. To blind the interpretation to cytologic features, nuclei and cytoplasm were obscured using morphometric software (Zen 2011, Carl Zeiss Microscopy, Germany). 13/27 cases (48%; 8 pattern-A, 5 benign) were correctly classified by all reviewers; 19/27 (70%; 10 pattern-A, 9 benign) were correctly classified by ≥2 reviewers. 3/13 pattern-A cases (23%) were interpreted as benign by ≥2 reviewers. Conversely, 5/14 benign cervices (36%) were misinterpreted as pattern-A by ≥2 reviewers. The number of glands per 20× field was higher in pattern-A cases with high reviewer agreement (p = 0.004). An abnormal architecture is seen in many pattern-A adenocarcinomas in support of their invasive nature; some, however, have architecture that overlaps with that of benign endocervix thus may actually represent in-situ lesions. Likewise, normal cervix can be architecturally complex and mirror patterns that pathologists would classify as pattern-A if malignant cytologic features were present. Based on this overlap and the nil risk of nodal spread, an emphasis on the non-destructive, rather than the invasive, nature of pattern-A adenocarcinoma is recommended.

Original languageEnglish (US)
Pages (from-to)799-803
Number of pages5
JournalPathology Research and Practice
Volume213
Issue number7
DOIs
StatePublished - Jul 1 2017

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Adenocarcinoma
Cervix Uteri
Neoplasms
Germany
Microscopy
Cytoplasm
Software
Neoplasm Metastasis
Pathologists

Keywords

  • Cervical adenocarcinoma
  • Cervix histology
  • Pattern based classification

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology

Cite this

Architectural overlap between benign endocervix and pattern-A endocervical adenocarcinoma : Are all pattern-A tumors invasive? / Douglas, Gregory; Howitt, Brooke E.; Schoolmeester, J. Kenneth; Schwartz, Lauren; Kos, Zuzana; Islam, Shahidul; Djordjevic, Bojana; Parra-Herran, Carlos.

In: Pathology Research and Practice, Vol. 213, No. 7, 01.07.2017, p. 799-803.

Research output: Contribution to journalArticle

Douglas, Gregory ; Howitt, Brooke E. ; Schoolmeester, J. Kenneth ; Schwartz, Lauren ; Kos, Zuzana ; Islam, Shahidul ; Djordjevic, Bojana ; Parra-Herran, Carlos. / Architectural overlap between benign endocervix and pattern-A endocervical adenocarcinoma : Are all pattern-A tumors invasive?. In: Pathology Research and Practice. 2017 ; Vol. 213, No. 7. pp. 799-803.
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