Abstract
Epigenetic regulatory information must be retained during mammalian cell division to sustain phenotypespecific and physiologically responsive gene expression in the progeny cells. Histone modifications, DNA methylation, and RNA-mediated silencing are well-defined epigenetic mechanisms that control the cellular phenotype by regulating gene expression. Recent results suggest that the mitotic retention of nuclease hypersensitivity, selective histone marks, as well as the lineage-specific transcription factor occupancy of promoter elements contribute to the epigenetic control of sustained cellular identity in progeny cells. We propose that these mitotic epigenetic signatures collectively constitute architectural epigenetics, a novel and essential mechanism that conveys regulatory information to sustain the control of phenotype and proliferation in progeny cells by bookmarking genes for activation or suppression.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4758-4766 |
| Number of pages | 9 |
| Journal | Molecular and Cellular Biology |
| Volume | 30 |
| Issue number | 20 |
| DOIs | |
| State | Published - Oct 2010 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Molecular Biology
- Cell Biology
Cite this
Architectural epigenetics : Mitotic retention of mammalian transcriptional regulatory information. / Zaidi, Sayyed K.; Young, Daniel W.; Montecino, Martin; Lian, Jane B.; Stein, Janet L.; van Wijnen, Andre J; Stein, Gary S.
In: Molecular and Cellular Biology, Vol. 30, No. 20, 10.2010, p. 4758-4766.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Architectural epigenetics
T2 - Mitotic retention of mammalian transcriptional regulatory information
AU - Zaidi, Sayyed K.
AU - Young, Daniel W.
AU - Montecino, Martin
AU - Lian, Jane B.
AU - Stein, Janet L.
AU - van Wijnen, Andre J
AU - Stein, Gary S.
PY - 2010/10
Y1 - 2010/10
N2 - Epigenetic regulatory information must be retained during mammalian cell division to sustain phenotypespecific and physiologically responsive gene expression in the progeny cells. Histone modifications, DNA methylation, and RNA-mediated silencing are well-defined epigenetic mechanisms that control the cellular phenotype by regulating gene expression. Recent results suggest that the mitotic retention of nuclease hypersensitivity, selective histone marks, as well as the lineage-specific transcription factor occupancy of promoter elements contribute to the epigenetic control of sustained cellular identity in progeny cells. We propose that these mitotic epigenetic signatures collectively constitute architectural epigenetics, a novel and essential mechanism that conveys regulatory information to sustain the control of phenotype and proliferation in progeny cells by bookmarking genes for activation or suppression.
AB - Epigenetic regulatory information must be retained during mammalian cell division to sustain phenotypespecific and physiologically responsive gene expression in the progeny cells. Histone modifications, DNA methylation, and RNA-mediated silencing are well-defined epigenetic mechanisms that control the cellular phenotype by regulating gene expression. Recent results suggest that the mitotic retention of nuclease hypersensitivity, selective histone marks, as well as the lineage-specific transcription factor occupancy of promoter elements contribute to the epigenetic control of sustained cellular identity in progeny cells. We propose that these mitotic epigenetic signatures collectively constitute architectural epigenetics, a novel and essential mechanism that conveys regulatory information to sustain the control of phenotype and proliferation in progeny cells by bookmarking genes for activation or suppression.
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UR - http://www.scopus.com/inward/citedby.url?scp=78049404909&partnerID=8YFLogxK
U2 - 10.1128/MCB.00646-10
DO - 10.1128/MCB.00646-10
M3 - Article
C2 - 20696837
AN - SCOPUS:78049404909
VL - 30
SP - 4758
EP - 4766
JO - Molecular and Cellular Biology
JF - Molecular and Cellular Biology
SN - 0270-7306
IS - 20
ER -