Architectural epigenetics: Mitotic retention of mammalian transcriptional regulatory information

Sayyed K. Zaidi, Daniel W. Young, Martin Montecino, Jane B. Lian, Janet L. Stein, Andre J. van Wijnen, Gary S. Stein

Research output: Contribution to journalShort survey

34 Scopus citations

Abstract

Epigenetic regulatory information must be retained during mammalian cell division to sustain phenotypespecific and physiologically responsive gene expression in the progeny cells. Histone modifications, DNA methylation, and RNA-mediated silencing are well-defined epigenetic mechanisms that control the cellular phenotype by regulating gene expression. Recent results suggest that the mitotic retention of nuclease hypersensitivity, selective histone marks, as well as the lineage-specific transcription factor occupancy of promoter elements contribute to the epigenetic control of sustained cellular identity in progeny cells. We propose that these mitotic epigenetic signatures collectively constitute architectural epigenetics, a novel and essential mechanism that conveys regulatory information to sustain the control of phenotype and proliferation in progeny cells by bookmarking genes for activation or suppression.

Original languageEnglish (US)
Pages (from-to)4758-4766
Number of pages9
JournalMolecular and cellular biology
Volume30
Issue number20
DOIs
StatePublished - Oct 1 2010

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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    Zaidi, S. K., Young, D. W., Montecino, M., Lian, J. B., Stein, J. L., van Wijnen, A. J., & Stein, G. S. (2010). Architectural epigenetics: Mitotic retention of mammalian transcriptional regulatory information. Molecular and cellular biology, 30(20), 4758-4766. https://doi.org/10.1128/MCB.00646-10