Abstract
Epigenetic regulatory information must be retained during mammalian cell division to sustain phenotypespecific and physiologically responsive gene expression in the progeny cells. Histone modifications, DNA methylation, and RNA-mediated silencing are well-defined epigenetic mechanisms that control the cellular phenotype by regulating gene expression. Recent results suggest that the mitotic retention of nuclease hypersensitivity, selective histone marks, as well as the lineage-specific transcription factor occupancy of promoter elements contribute to the epigenetic control of sustained cellular identity in progeny cells. We propose that these mitotic epigenetic signatures collectively constitute architectural epigenetics, a novel and essential mechanism that conveys regulatory information to sustain the control of phenotype and proliferation in progeny cells by bookmarking genes for activation or suppression.
Original language | English (US) |
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Pages (from-to) | 4758-4766 |
Number of pages | 9 |
Journal | Molecular and cellular biology |
Volume | 30 |
Issue number | 20 |
DOIs | |
State | Published - Oct 2010 |
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology