Aqueous extract of Ma huang suppresses neuropeptide y expression in food-deprived rat hypothalamus

Ee Hwa Kim; Mal Soon Shin; Hyun Kyung Chang; Taeck Hyun Lee; Mi Hyeon Jang; Min Chul Shin; Sam Jun Lee; Chang Ju Kim

doi:10.1142/S0192415X04002326

Aqueous extract of Ma huang suppresses neuropeptide y expression in food-deprived rat hypothalamus

Ee Hwa Kim, Mal Soon Shin, Hyun Kyung Chang, Taeck Hyun Lee, Mi Hyeon Jang, Min Chul Shin, Sam Jun Lee, Chang Ju Kim

Neurosurgery

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Ma huang, the dried plant stem of Ephedra Intermedia Schrenk et C.A., contains an ephedrine-type alkaloid and has been used for weight loss. Neuropeptide Y (NPY), a 36-amino acid peptide, is concentrated in the hypothalamus and stimulates feeding desire. In this study, the effect of Ma huang on the expressions of NPY in the hypothalamus of rats was investigated using immunohistochemistry. Food-deprivation enhanced the NPY expression in the hypothalamus. Ma huang suppressed the food-deprivation-induced enhancement of NPY expression. Present results suggest that Ma huang curbs the food desire by suppressing the NPY expression under food-deprivation conditions.

Original language	English (US)
Pages (from-to)	659-667
Number of pages	9
Journal	American Journal of Chinese Medicine
Volume	32
Issue number	5
DOIs	https://doi.org/10.1142/S0192415X04002326
State	Published - 2004

Keywords

Hypothalamus
Immunohistochemistry
Ma huang
Neuropeptide Y

ASJC Scopus subject areas

Complementary and alternative medicine

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10.1142/S0192415X04002326

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@article{17bad06f37f34bccbdd7d2014d455459,

title = "Aqueous extract of Ma huang suppresses neuropeptide y expression in food-deprived rat hypothalamus",

abstract = "Ma huang, the dried plant stem of Ephedra Intermedia Schrenk et C.A., contains an ephedrine-type alkaloid and has been used for weight loss. Neuropeptide Y (NPY), a 36-amino acid peptide, is concentrated in the hypothalamus and stimulates feeding desire. In this study, the effect of Ma huang on the expressions of NPY in the hypothalamus of rats was investigated using immunohistochemistry. Food-deprivation enhanced the NPY expression in the hypothalamus. Ma huang suppressed the food-deprivation-induced enhancement of NPY expression. Present results suggest that Ma huang curbs the food desire by suppressing the NPY expression under food-deprivation conditions.",

keywords = "Hypothalamus, Immunohistochemistry, Ma huang, Neuropeptide Y",

author = "Kim, {Ee Hwa} and Shin, {Mal Soon} and Chang, {Hyun Kyung} and Lee, {Taeck Hyun} and Jang, {Mi Hyeon} and Shin, {Min Chul} and Lee, {Sam Jun} and Kim, {Chang Ju}",

note = "Funding Information: This study was supported by a grant of the Oriental Medicine R&D Project, Ministry of Health and Welfare, Republic of Korea (HMP-02-PJ9-PG3-20600-0003).",

year = "2004",

doi = "10.1142/S0192415X04002326",

language = "English (US)",

volume = "32",

pages = "659--667",

journal = "American Journal of Chinese Medicine",

issn = "0192-415X",

publisher = "World Scientific Publishing Co. Pte Ltd",

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T1 - Aqueous extract of Ma huang suppresses neuropeptide y expression in food-deprived rat hypothalamus

AU - Kim, Ee Hwa

AU - Shin, Mal Soon

AU - Chang, Hyun Kyung

AU - Lee, Taeck Hyun

AU - Jang, Mi Hyeon

AU - Shin, Min Chul

AU - Lee, Sam Jun

AU - Kim, Chang Ju

N1 - Funding Information: This study was supported by a grant of the Oriental Medicine R&D Project, Ministry of Health and Welfare, Republic of Korea (HMP-02-PJ9-PG3-20600-0003).

PY - 2004

Y1 - 2004

N2 - Ma huang, the dried plant stem of Ephedra Intermedia Schrenk et C.A., contains an ephedrine-type alkaloid and has been used for weight loss. Neuropeptide Y (NPY), a 36-amino acid peptide, is concentrated in the hypothalamus and stimulates feeding desire. In this study, the effect of Ma huang on the expressions of NPY in the hypothalamus of rats was investigated using immunohistochemistry. Food-deprivation enhanced the NPY expression in the hypothalamus. Ma huang suppressed the food-deprivation-induced enhancement of NPY expression. Present results suggest that Ma huang curbs the food desire by suppressing the NPY expression under food-deprivation conditions.

AB - Ma huang, the dried plant stem of Ephedra Intermedia Schrenk et C.A., contains an ephedrine-type alkaloid and has been used for weight loss. Neuropeptide Y (NPY), a 36-amino acid peptide, is concentrated in the hypothalamus and stimulates feeding desire. In this study, the effect of Ma huang on the expressions of NPY in the hypothalamus of rats was investigated using immunohistochemistry. Food-deprivation enhanced the NPY expression in the hypothalamus. Ma huang suppressed the food-deprivation-induced enhancement of NPY expression. Present results suggest that Ma huang curbs the food desire by suppressing the NPY expression under food-deprivation conditions.

KW - Hypothalamus

KW - Immunohistochemistry

KW - Ma huang

KW - Neuropeptide Y

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SN - 0192-415X

VL - 32

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EP - 667

JO - American Journal of Chinese Medicine

JF - American Journal of Chinese Medicine

IS - 5

ER -

Aqueous extract of Ma huang suppresses neuropeptide y expression in food-deprived rat hypothalamus

Abstract

Keywords

ASJC Scopus subject areas

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