Aqueous extract of Ma huang suppresses neuropeptide y expression in food-deprived rat hypothalamus

Ee Hwa Kim, Mal Soon Shin, Hyun Kyung Chang, Taeck Hyun Lee, Mi-Hyeon D Jang, Min Chul Shin, Sam Jun Lee, Chang Ju Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Ma huang, the dried plant stem of Ephedra Intermedia Schrenk et C.A., contains an ephedrine-type alkaloid and has been used for weight loss. Neuropeptide Y (NPY), a 36-amino acid peptide, is concentrated in the hypothalamus and stimulates feeding desire. In this study, the effect of Ma huang on the expressions of NPY in the hypothalamus of rats was investigated using immunohistochemistry. Food-deprivation enhanced the NPY expression in the hypothalamus. Ma huang suppressed the food-deprivation-induced enhancement of NPY expression. Present results suggest that Ma huang curbs the food desire by suppressing the NPY expression under food-deprivation conditions.

Original languageEnglish (US)
Pages (from-to)659-667
Number of pages9
JournalAmerican Journal of Chinese Medicine
Volume32
Issue number5
DOIs
StatePublished - 2004
Externally publishedYes

Fingerprint

Ephedra sinica
Neuropeptide Y
Neuropeptides
Hypothalamus
Food Deprivation
Food
Ephedra
Plant Stems
Ephedrine
Alkaloids
Weight Loss
Immunohistochemistry
Amino Acids
Peptides

Keywords

  • Hypothalamus
  • Immunohistochemistry
  • Ma huang
  • Neuropeptide Y

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

Aqueous extract of Ma huang suppresses neuropeptide y expression in food-deprived rat hypothalamus. / Kim, Ee Hwa; Shin, Mal Soon; Chang, Hyun Kyung; Lee, Taeck Hyun; Jang, Mi-Hyeon D; Shin, Min Chul; Lee, Sam Jun; Kim, Chang Ju.

In: American Journal of Chinese Medicine, Vol. 32, No. 5, 2004, p. 659-667.

Research output: Contribution to journalArticle

Kim, Ee Hwa ; Shin, Mal Soon ; Chang, Hyun Kyung ; Lee, Taeck Hyun ; Jang, Mi-Hyeon D ; Shin, Min Chul ; Lee, Sam Jun ; Kim, Chang Ju. / Aqueous extract of Ma huang suppresses neuropeptide y expression in food-deprived rat hypothalamus. In: American Journal of Chinese Medicine. 2004 ; Vol. 32, No. 5. pp. 659-667.
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AU - Lee, Sam Jun

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