Aqueductal Cerebrospinal Fluid Stroke Volume Flow in a Rodent Model of Chronic Communicating Hydrocephalus: Establishing a Homogeneous Study Population for Cerebrospinal Fluid Dynamics Exploration

Tito Vivas-Buitrago, Armelle Lokossou, Ignacio Jusué-Torres, Gabriel Pinilla-Monsalve, Ari M. Blitz, Daniel A. Herzka, Jamie Robison, Jiadi Xu, Hugo Guerrero Cazares, Susumu Mori, Alfredo Quinones-Hinojosa, Olivier Baledént, Daniele Rigamonti

Research output: Contribution to journalArticle

Abstract

Background: Idiopathic normal pressure hydrocephalus (iNPH) is a cause of dementia that can be reversed when treated timely with cerebrospinal fluid (CSF) diversion. Understanding CSF dynamics throughout the development of hydrocephalus is crucial to identify prognostic markers to estimate benefit/risk to shunts. Objective: To explore the cerebral aqueduct CSF flow dynamics with phase-contrast magnetic resonance imaging (MRI) in a novel rodent model of adult chronic communicating hydrocephalus. Methods: Kaolin was injected into the subarachnoid space at the convexities in Sprague-Dawley adult rats. 11.7-T Bruker MRI was used to acquire T2-weighted images for anatomic identification and phase-contrast MRI at the cerebral aqueduct. Aqueductal stroke volume (ASV) results were compared with the ventricular volume (VV) at 15, 60, 90, and 120 days. Results: Significant ventricular enlargement was found in kaolin-injected animals at all times (P < 0.001). ASV differed between cases and controls/shams at every time point (P = 0.004, 0.001, 0.001, and <0.001 at 15, 60, 90, and 120 days, respectively). After correlation between the ASV and the VV, there was a significant correlation at 15 (P = 0.015), 60 (P = 0.001), 90 (P < 0.001), and 120 days. Moreover, there was a significant positive correlation between the VV expansion and the aqueductal CSF stroke between 15 and 60 days. Conclusions: An initial active phase of rapid ventricular enlargement shows a strong correlation between the expansion of the VV and the increment in the ASV during the first 60 days, followed by a second phase with less ventricular enlargement and heterogeneous behavior in the ASV. Further correlation with complementary data from intracranial pressure and histologic/microstructural brain parenchyma assessments are needed to better understand the ASV variations after 60 days.

Original languageEnglish (US)
JournalWorld neurosurgery
DOIs
StatePublished - Jan 1 2019

Fingerprint

Hydrodynamics
Hydrocephalus
Stroke Volume
Cerebrospinal Fluid
Rodentia
Cerebral Aqueduct
Population
Kaolin
Magnetic Resonance Imaging
Normal Pressure Hydrocephalus
Subarachnoid Space
Intracranial Pressure
Sprague Dawley Rats
Dementia
Stroke
Brain

Keywords

  • Aqueduct
  • Chronic
  • Communicating hydrocephalus
  • iNPH
  • Phase-contrast MRI
  • Stroke volume

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Aqueductal Cerebrospinal Fluid Stroke Volume Flow in a Rodent Model of Chronic Communicating Hydrocephalus : Establishing a Homogeneous Study Population for Cerebrospinal Fluid Dynamics Exploration. / Vivas-Buitrago, Tito; Lokossou, Armelle; Jusué-Torres, Ignacio; Pinilla-Monsalve, Gabriel; Blitz, Ari M.; Herzka, Daniel A.; Robison, Jamie; Xu, Jiadi; Guerrero Cazares, Hugo; Mori, Susumu; Quinones-Hinojosa, Alfredo; Baledént, Olivier; Rigamonti, Daniele.

In: World neurosurgery, 01.01.2019.

Research output: Contribution to journalArticle

Vivas-Buitrago, Tito ; Lokossou, Armelle ; Jusué-Torres, Ignacio ; Pinilla-Monsalve, Gabriel ; Blitz, Ari M. ; Herzka, Daniel A. ; Robison, Jamie ; Xu, Jiadi ; Guerrero Cazares, Hugo ; Mori, Susumu ; Quinones-Hinojosa, Alfredo ; Baledént, Olivier ; Rigamonti, Daniele. / Aqueductal Cerebrospinal Fluid Stroke Volume Flow in a Rodent Model of Chronic Communicating Hydrocephalus : Establishing a Homogeneous Study Population for Cerebrospinal Fluid Dynamics Exploration. In: World neurosurgery. 2019.
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abstract = "Background: Idiopathic normal pressure hydrocephalus (iNPH) is a cause of dementia that can be reversed when treated timely with cerebrospinal fluid (CSF) diversion. Understanding CSF dynamics throughout the development of hydrocephalus is crucial to identify prognostic markers to estimate benefit/risk to shunts. Objective: To explore the cerebral aqueduct CSF flow dynamics with phase-contrast magnetic resonance imaging (MRI) in a novel rodent model of adult chronic communicating hydrocephalus. Methods: Kaolin was injected into the subarachnoid space at the convexities in Sprague-Dawley adult rats. 11.7-T Bruker MRI was used to acquire T2-weighted images for anatomic identification and phase-contrast MRI at the cerebral aqueduct. Aqueductal stroke volume (ASV) results were compared with the ventricular volume (VV) at 15, 60, 90, and 120 days. Results: Significant ventricular enlargement was found in kaolin-injected animals at all times (P < 0.001). ASV differed between cases and controls/shams at every time point (P = 0.004, 0.001, 0.001, and <0.001 at 15, 60, 90, and 120 days, respectively). After correlation between the ASV and the VV, there was a significant correlation at 15 (P = 0.015), 60 (P = 0.001), 90 (P < 0.001), and 120 days. Moreover, there was a significant positive correlation between the VV expansion and the aqueductal CSF stroke between 15 and 60 days. Conclusions: An initial active phase of rapid ventricular enlargement shows a strong correlation between the expansion of the VV and the increment in the ASV during the first 60 days, followed by a second phase with less ventricular enlargement and heterogeneous behavior in the ASV. Further correlation with complementary data from intracranial pressure and histologic/microstructural brain parenchyma assessments are needed to better understand the ASV variations after 60 days.",
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T2 - Establishing a Homogeneous Study Population for Cerebrospinal Fluid Dynamics Exploration

AU - Vivas-Buitrago, Tito

AU - Lokossou, Armelle

AU - Jusué-Torres, Ignacio

AU - Pinilla-Monsalve, Gabriel

AU - Blitz, Ari M.

AU - Herzka, Daniel A.

AU - Robison, Jamie

AU - Xu, Jiadi

AU - Guerrero Cazares, Hugo

AU - Mori, Susumu

AU - Quinones-Hinojosa, Alfredo

AU - Baledént, Olivier

AU - Rigamonti, Daniele

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Idiopathic normal pressure hydrocephalus (iNPH) is a cause of dementia that can be reversed when treated timely with cerebrospinal fluid (CSF) diversion. Understanding CSF dynamics throughout the development of hydrocephalus is crucial to identify prognostic markers to estimate benefit/risk to shunts. Objective: To explore the cerebral aqueduct CSF flow dynamics with phase-contrast magnetic resonance imaging (MRI) in a novel rodent model of adult chronic communicating hydrocephalus. Methods: Kaolin was injected into the subarachnoid space at the convexities in Sprague-Dawley adult rats. 11.7-T Bruker MRI was used to acquire T2-weighted images for anatomic identification and phase-contrast MRI at the cerebral aqueduct. Aqueductal stroke volume (ASV) results were compared with the ventricular volume (VV) at 15, 60, 90, and 120 days. Results: Significant ventricular enlargement was found in kaolin-injected animals at all times (P < 0.001). ASV differed between cases and controls/shams at every time point (P = 0.004, 0.001, 0.001, and <0.001 at 15, 60, 90, and 120 days, respectively). After correlation between the ASV and the VV, there was a significant correlation at 15 (P = 0.015), 60 (P = 0.001), 90 (P < 0.001), and 120 days. Moreover, there was a significant positive correlation between the VV expansion and the aqueductal CSF stroke between 15 and 60 days. Conclusions: An initial active phase of rapid ventricular enlargement shows a strong correlation between the expansion of the VV and the increment in the ASV during the first 60 days, followed by a second phase with less ventricular enlargement and heterogeneous behavior in the ASV. Further correlation with complementary data from intracranial pressure and histologic/microstructural brain parenchyma assessments are needed to better understand the ASV variations after 60 days.

AB - Background: Idiopathic normal pressure hydrocephalus (iNPH) is a cause of dementia that can be reversed when treated timely with cerebrospinal fluid (CSF) diversion. Understanding CSF dynamics throughout the development of hydrocephalus is crucial to identify prognostic markers to estimate benefit/risk to shunts. Objective: To explore the cerebral aqueduct CSF flow dynamics with phase-contrast magnetic resonance imaging (MRI) in a novel rodent model of adult chronic communicating hydrocephalus. Methods: Kaolin was injected into the subarachnoid space at the convexities in Sprague-Dawley adult rats. 11.7-T Bruker MRI was used to acquire T2-weighted images for anatomic identification and phase-contrast MRI at the cerebral aqueduct. Aqueductal stroke volume (ASV) results were compared with the ventricular volume (VV) at 15, 60, 90, and 120 days. Results: Significant ventricular enlargement was found in kaolin-injected animals at all times (P < 0.001). ASV differed between cases and controls/shams at every time point (P = 0.004, 0.001, 0.001, and <0.001 at 15, 60, 90, and 120 days, respectively). After correlation between the ASV and the VV, there was a significant correlation at 15 (P = 0.015), 60 (P = 0.001), 90 (P < 0.001), and 120 days. Moreover, there was a significant positive correlation between the VV expansion and the aqueductal CSF stroke between 15 and 60 days. Conclusions: An initial active phase of rapid ventricular enlargement shows a strong correlation between the expansion of the VV and the increment in the ASV during the first 60 days, followed by a second phase with less ventricular enlargement and heterogeneous behavior in the ASV. Further correlation with complementary data from intracranial pressure and histologic/microstructural brain parenchyma assessments are needed to better understand the ASV variations after 60 days.

KW - Aqueduct

KW - Chronic

KW - Communicating hydrocephalus

KW - iNPH

KW - Phase-contrast MRI

KW - Stroke volume

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