Aprotinin for coronary artery bypass grafting: Effect on postoperative renal function

John H. Lemmer, William Stanford, Sharon L. Bonney, Eva V. Chomka, Robert B. Karp, Glenn W. Laub, John A. Rumberger, Hartzell V Schaff

Research output: Contribution to journalArticle

78 Scopus citations

Abstract

Two hundred sixteen patients undergoing coronary artery bypass graft procedures were randomized to receive either high-dose aprotinin or placebo. Clinically important postoperative renal insufficiency was infrequent, with a single patient (0.9%) from each group requiring dialysis. Although increases in the serum creatinine level occurred postoperatively in more patients who received aprotinin (20/108) than in those given placebo (13/108), the difference between the two group was not statistically significant (p = 0.186), and the increases were generally small and transient. Likewise, there was no difference between the groups in terms of the incidence of abnormal serum electrolyte levels, blood era nitrogen levels, or urinalysis findings, or in the frequency of abnormal creatinine clearance rates. Under the conditions described, aprotinin use does not appear to be associated with a significant risk of serious renal toxicity.

Original languageEnglish (US)
Pages (from-to)132-136
Number of pages5
JournalThe Annals of Thoracic Surgery
Volume59
Issue number1
DOIs
StatePublished - 1995

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

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    Lemmer, J. H., Stanford, W., Bonney, S. L., Chomka, E. V., Karp, R. B., Laub, G. W., Rumberger, J. A., & Schaff, H. V. (1995). Aprotinin for coronary artery bypass grafting: Effect on postoperative renal function. The Annals of Thoracic Surgery, 59(1), 132-136. https://doi.org/10.1016/0003-4975(94)00813-M