Apraxia of speech and nonfluent aphasia: A new clinical marker for corticobasal degeneration and progressive supranuclear palsy

Keith A. Josephs, Joseph R. Duffy

Research output: Contribution to journalReview article

110 Scopus citations

Abstract

Purpose of review: To highlight the fact that patients with corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) can sometimes present with a progressive apraxia of speech, nonfluent aphasia, or a combination of the two disorders. Recent findings: Corticobasal degeneration and PSP are neurodegenerative diseases characterized by neuronal loss and gliosis in cardinal brain regions, as well as the abnormal deposition of the microtubule associated protein tau in cell bodies and cell processes. The typical presenting features of CBD and PSP are akinesia and rigidity that are levodopa unresponsive, although there has been evidence that both diseases, moreso CBD, can present with a dementia syndrome. Recent clinicopathological studies have now also demonstrated that a subset of patients with CBD and PSP present with a progressive apraxia of speech, nonfluent aphasia, or a combination of the two disorders. Summary: Presenting features of progressive apraxia of speech or nonfluent aphasia are strongly associated with a diagnosis of CBD, PSP, or both.

Original languageEnglish (US)
Pages (from-to)688-692
Number of pages5
JournalCurrent opinion in neurology
Volume21
Issue number6
DOIs
StatePublished - Dec 1 2008

Keywords

  • Apraxia of speech
  • Corticobasal degeneration
  • Nonfluent aphasia
  • Progressive supranuclear palsy
  • Tau

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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