TY - JOUR
T1 - Apraxia of speech and nonfluent aphasia
T2 - A new clinical marker for corticobasal degeneration and progressive supranuclear palsy
AU - Josephs, Keith A.
AU - Duffy, Joseph R.
PY - 2008/12
Y1 - 2008/12
N2 - Purpose of review: To highlight the fact that patients with corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) can sometimes present with a progressive apraxia of speech, nonfluent aphasia, or a combination of the two disorders. Recent findings: Corticobasal degeneration and PSP are neurodegenerative diseases characterized by neuronal loss and gliosis in cardinal brain regions, as well as the abnormal deposition of the microtubule associated protein tau in cell bodies and cell processes. The typical presenting features of CBD and PSP are akinesia and rigidity that are levodopa unresponsive, although there has been evidence that both diseases, moreso CBD, can present with a dementia syndrome. Recent clinicopathological studies have now also demonstrated that a subset of patients with CBD and PSP present with a progressive apraxia of speech, nonfluent aphasia, or a combination of the two disorders. Summary: Presenting features of progressive apraxia of speech or nonfluent aphasia are strongly associated with a diagnosis of CBD, PSP, or both.
AB - Purpose of review: To highlight the fact that patients with corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) can sometimes present with a progressive apraxia of speech, nonfluent aphasia, or a combination of the two disorders. Recent findings: Corticobasal degeneration and PSP are neurodegenerative diseases characterized by neuronal loss and gliosis in cardinal brain regions, as well as the abnormal deposition of the microtubule associated protein tau in cell bodies and cell processes. The typical presenting features of CBD and PSP are akinesia and rigidity that are levodopa unresponsive, although there has been evidence that both diseases, moreso CBD, can present with a dementia syndrome. Recent clinicopathological studies have now also demonstrated that a subset of patients with CBD and PSP present with a progressive apraxia of speech, nonfluent aphasia, or a combination of the two disorders. Summary: Presenting features of progressive apraxia of speech or nonfluent aphasia are strongly associated with a diagnosis of CBD, PSP, or both.
KW - Apraxia of speech
KW - Corticobasal degeneration
KW - Nonfluent aphasia
KW - Progressive supranuclear palsy
KW - Tau
UR - http://www.scopus.com/inward/record.url?scp=56749083283&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=56749083283&partnerID=8YFLogxK
U2 - 10.1097/WCO.0b013e3283168ddd
DO - 10.1097/WCO.0b013e3283168ddd
M3 - Review article
C2 - 18989114
AN - SCOPUS:56749083283
SN - 1350-7540
VL - 21
SP - 688
EP - 692
JO - Current opinion in neurology
JF - Current opinion in neurology
IS - 6
ER -