Appropriate Objective Functions for Quantifying Iris Mechanical Properties Using Inverse Finite Element Modeling

Anup D. Pant, Syril Dorairaj, Rouzbeh Amini

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Quantifying the mechanical properties of the iris is important, as it provides insight into the pathophysiology of glaucoma. Recent ex vivo studies have shown that the mechanical properties of the iris are different in glaucomatous eyes as compared to normal ones. Notwithstanding the importance of the ex vivo studies, such measurements are severely limited for diagnosis and preclude development of treatment strategies. With the advent of detailed imaging modalities, it is possible to determine the in vivo mechanical properties using inverse finite element (FE) modeling. An inverse modeling approach requires an appropriate objective function for reliable estimation of parameters. In the case of the iris, numerous measurements such as iris chord length (CL) and iris concavity (CV) are made routinely in clinical practice. In this study, we have evaluated five different objective functions chosen based on the iris biometrics (in the presence and absence of clinical measurement errors) to determine the appropriate criterion for inverse modeling. Our results showed that in the absence of experimental measurement error, a combination of iris CL and CV can be used as the objective function. However, with the addition of measurement errors, the objective functions that employ a large number of local displacement values provide more reliable outcomes.

Original languageEnglish (US)
Article number074502
JournalJournal of Biomechanical Engineering
Volume140
Issue number7
DOIs
StatePublished - Jul 1 2018

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physiology (medical)

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