Approaching a scientific consensus on the association between allergies and glioma risk

A report from the glioma international case-control study

E. Susan Amirian, Renke Zhou, Margaret R. Wrensch, Sara H. Olson, Michael E. Scheurer, Dora Il'Yasova, Daniel H Lachance, Georgina N. Armstrong, Lucie S. Mccoy, Ching C. Lau, Elizabeth B. Claus, Jill S. Barnholtz-Sloan, Joellen Schildkraut, Francis Ali-Osman, Siegal Sadetzki, Christoffer Johansen, Richard S. Houlston, Robert Brian Jenkins, Jonine L. Bernstein, Ryan T. Merrell & 6 others Faith G. Davis, Rose Lai, Sanjay Shete, Christopher I. Amos, Beatrice S. Melin, Melissa L. Bondy

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background: Several previous studies have found inverse associations between glioma susceptibility and a history of allergies or other atopic conditions. Some evidence indicates that respiratory allergies are likely to be particularly relevant with regard to glioma risk. Using data from the Glioma International Case-Control Study (GICC), we examined the effects of respiratory allergies and other atopic conditions on glioma risk. Methods: The GICC contains detailed information on history of atopic conditions for 4,533 cases and 4,171 controls, recruited from 14 study sites across five countries. Using two-stage randomeffects restricted maximum likelihood modeling to calculate meta-analysis ORs, we examined the associations between glioma and allergy status, respiratory allergy status, asthma, and eczema. Results: Having a history of respiratory allergies was associated with an approximately 30% lower glioma risk, compared with not having respiratory allergies (mOR, 0.72; 95% confidence interval, 0.58-0.90). This association was similar when restricting to highgrade glioma cases. Asthma and eczema were also significantly protective against glioma. Conclusion: A substantial amount of data on the inverse association between atopic conditions and glioma has accumulated, and findings from the GICC study further strengthen the existing evidence that the relationship between atopy and glioma is unlikely to be coincidental. Impact: As the literature approaches a consensus on the impact of allergies in glioma risk, future research can begin to shift focus to what the underlying biologic mechanism behind this association may be, which could, in turn, yield new opportunities for immunotherapy or cancer prevention.

Original languageEnglish (US)
Pages (from-to)282-290
Number of pages9
JournalCancer Epidemiology Biomarkers and Prevention
Volume25
Issue number2
DOIs
StatePublished - Feb 1 2016

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Glioma
Case-Control Studies
Hypersensitivity
Eczema
Asthma
Immunotherapy
Meta-Analysis
Confidence Intervals

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Approaching a scientific consensus on the association between allergies and glioma risk : A report from the glioma international case-control study. / Amirian, E. Susan; Zhou, Renke; Wrensch, Margaret R.; Olson, Sara H.; Scheurer, Michael E.; Il'Yasova, Dora; Lachance, Daniel H; Armstrong, Georgina N.; Mccoy, Lucie S.; Lau, Ching C.; Claus, Elizabeth B.; Barnholtz-Sloan, Jill S.; Schildkraut, Joellen; Ali-Osman, Francis; Sadetzki, Siegal; Johansen, Christoffer; Houlston, Richard S.; Jenkins, Robert Brian; Bernstein, Jonine L.; Merrell, Ryan T.; Davis, Faith G.; Lai, Rose; Shete, Sanjay; Amos, Christopher I.; Melin, Beatrice S.; Bondy, Melissa L.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 25, No. 2, 01.02.2016, p. 282-290.

Research output: Contribution to journalArticle

Amirian, ES, Zhou, R, Wrensch, MR, Olson, SH, Scheurer, ME, Il'Yasova, D, Lachance, DH, Armstrong, GN, Mccoy, LS, Lau, CC, Claus, EB, Barnholtz-Sloan, JS, Schildkraut, J, Ali-Osman, F, Sadetzki, S, Johansen, C, Houlston, RS, Jenkins, RB, Bernstein, JL, Merrell, RT, Davis, FG, Lai, R, Shete, S, Amos, CI, Melin, BS & Bondy, ML 2016, 'Approaching a scientific consensus on the association between allergies and glioma risk: A report from the glioma international case-control study', Cancer Epidemiology Biomarkers and Prevention, vol. 25, no. 2, pp. 282-290. https://doi.org/10.1158/1055-9965.EPI-15-0847
Amirian, E. Susan ; Zhou, Renke ; Wrensch, Margaret R. ; Olson, Sara H. ; Scheurer, Michael E. ; Il'Yasova, Dora ; Lachance, Daniel H ; Armstrong, Georgina N. ; Mccoy, Lucie S. ; Lau, Ching C. ; Claus, Elizabeth B. ; Barnholtz-Sloan, Jill S. ; Schildkraut, Joellen ; Ali-Osman, Francis ; Sadetzki, Siegal ; Johansen, Christoffer ; Houlston, Richard S. ; Jenkins, Robert Brian ; Bernstein, Jonine L. ; Merrell, Ryan T. ; Davis, Faith G. ; Lai, Rose ; Shete, Sanjay ; Amos, Christopher I. ; Melin, Beatrice S. ; Bondy, Melissa L. / Approaching a scientific consensus on the association between allergies and glioma risk : A report from the glioma international case-control study. In: Cancer Epidemiology Biomarkers and Prevention. 2016 ; Vol. 25, No. 2. pp. 282-290.
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abstract = "Background: Several previous studies have found inverse associations between glioma susceptibility and a history of allergies or other atopic conditions. Some evidence indicates that respiratory allergies are likely to be particularly relevant with regard to glioma risk. Using data from the Glioma International Case-Control Study (GICC), we examined the effects of respiratory allergies and other atopic conditions on glioma risk. Methods: The GICC contains detailed information on history of atopic conditions for 4,533 cases and 4,171 controls, recruited from 14 study sites across five countries. Using two-stage randomeffects restricted maximum likelihood modeling to calculate meta-analysis ORs, we examined the associations between glioma and allergy status, respiratory allergy status, asthma, and eczema. Results: Having a history of respiratory allergies was associated with an approximately 30{\%} lower glioma risk, compared with not having respiratory allergies (mOR, 0.72; 95{\%} confidence interval, 0.58-0.90). This association was similar when restricting to highgrade glioma cases. Asthma and eczema were also significantly protective against glioma. Conclusion: A substantial amount of data on the inverse association between atopic conditions and glioma has accumulated, and findings from the GICC study further strengthen the existing evidence that the relationship between atopy and glioma is unlikely to be coincidental. Impact: As the literature approaches a consensus on the impact of allergies in glioma risk, future research can begin to shift focus to what the underlying biologic mechanism behind this association may be, which could, in turn, yield new opportunities for immunotherapy or cancer prevention.",
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T2 - A report from the glioma international case-control study

AU - Amirian, E. Susan

AU - Zhou, Renke

AU - Wrensch, Margaret R.

AU - Olson, Sara H.

AU - Scheurer, Michael E.

AU - Il'Yasova, Dora

AU - Lachance, Daniel H

AU - Armstrong, Georgina N.

AU - Mccoy, Lucie S.

AU - Lau, Ching C.

AU - Claus, Elizabeth B.

AU - Barnholtz-Sloan, Jill S.

AU - Schildkraut, Joellen

AU - Ali-Osman, Francis

AU - Sadetzki, Siegal

AU - Johansen, Christoffer

AU - Houlston, Richard S.

AU - Jenkins, Robert Brian

AU - Bernstein, Jonine L.

AU - Merrell, Ryan T.

AU - Davis, Faith G.

AU - Lai, Rose

AU - Shete, Sanjay

AU - Amos, Christopher I.

AU - Melin, Beatrice S.

AU - Bondy, Melissa L.

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