Abstract
Background: Several previous studies have found inverse associations between glioma susceptibility and a history of allergies or other atopic conditions. Some evidence indicates that respiratory allergies are likely to be particularly relevant with regard to glioma risk. Using data from the Glioma International Case-Control Study (GICC), we examined the effects of respiratory allergies and other atopic conditions on glioma risk. Methods: The GICC contains detailed information on history of atopic conditions for 4,533 cases and 4,171 controls, recruited from 14 study sites across five countries. Using two-stage randomeffects restricted maximum likelihood modeling to calculate meta-analysis ORs, we examined the associations between glioma and allergy status, respiratory allergy status, asthma, and eczema. Results: Having a history of respiratory allergies was associated with an approximately 30% lower glioma risk, compared with not having respiratory allergies (mOR, 0.72; 95% confidence interval, 0.58-0.90). This association was similar when restricting to highgrade glioma cases. Asthma and eczema were also significantly protective against glioma. Conclusion: A substantial amount of data on the inverse association between atopic conditions and glioma has accumulated, and findings from the GICC study further strengthen the existing evidence that the relationship between atopy and glioma is unlikely to be coincidental. Impact: As the literature approaches a consensus on the impact of allergies in glioma risk, future research can begin to shift focus to what the underlying biologic mechanism behind this association may be, which could, in turn, yield new opportunities for immunotherapy or cancer prevention.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 282-290 |
| Number of pages | 9 |
| Journal | Cancer Epidemiology Biomarkers and Prevention |
| Volume | 25 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 2016 |
Fingerprint
ASJC Scopus subject areas
- Epidemiology
- Oncology
Cite this
Approaching a scientific consensus on the association between allergies and glioma risk : A report from the glioma international case-control study. / Amirian, E. Susan; Zhou, Renke; Wrensch, Margaret R.; Olson, Sara H.; Scheurer, Michael E.; Il'Yasova, Dora; Lachance, Daniel H; Armstrong, Georgina N.; Mccoy, Lucie S.; Lau, Ching C.; Claus, Elizabeth B.; Barnholtz-Sloan, Jill S.; Schildkraut, Joellen; Ali-Osman, Francis; Sadetzki, Siegal; Johansen, Christoffer; Houlston, Richard S.; Jenkins, Robert Brian; Bernstein, Jonine L.; Merrell, Ryan T.; Davis, Faith G.; Lai, Rose; Shete, Sanjay; Amos, Christopher I.; Melin, Beatrice S.; Bondy, Melissa L.
In: Cancer Epidemiology Biomarkers and Prevention, Vol. 25, No. 2, 01.02.2016, p. 282-290.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Approaching a scientific consensus on the association between allergies and glioma risk
T2 - A report from the glioma international case-control study
AU - Amirian, E. Susan
AU - Zhou, Renke
AU - Wrensch, Margaret R.
AU - Olson, Sara H.
AU - Scheurer, Michael E.
AU - Il'Yasova, Dora
AU - Lachance, Daniel H
AU - Armstrong, Georgina N.
AU - Mccoy, Lucie S.
AU - Lau, Ching C.
AU - Claus, Elizabeth B.
AU - Barnholtz-Sloan, Jill S.
AU - Schildkraut, Joellen
AU - Ali-Osman, Francis
AU - Sadetzki, Siegal
AU - Johansen, Christoffer
AU - Houlston, Richard S.
AU - Jenkins, Robert Brian
AU - Bernstein, Jonine L.
AU - Merrell, Ryan T.
AU - Davis, Faith G.
AU - Lai, Rose
AU - Shete, Sanjay
AU - Amos, Christopher I.
AU - Melin, Beatrice S.
AU - Bondy, Melissa L.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Background: Several previous studies have found inverse associations between glioma susceptibility and a history of allergies or other atopic conditions. Some evidence indicates that respiratory allergies are likely to be particularly relevant with regard to glioma risk. Using data from the Glioma International Case-Control Study (GICC), we examined the effects of respiratory allergies and other atopic conditions on glioma risk. Methods: The GICC contains detailed information on history of atopic conditions for 4,533 cases and 4,171 controls, recruited from 14 study sites across five countries. Using two-stage randomeffects restricted maximum likelihood modeling to calculate meta-analysis ORs, we examined the associations between glioma and allergy status, respiratory allergy status, asthma, and eczema. Results: Having a history of respiratory allergies was associated with an approximately 30% lower glioma risk, compared with not having respiratory allergies (mOR, 0.72; 95% confidence interval, 0.58-0.90). This association was similar when restricting to highgrade glioma cases. Asthma and eczema were also significantly protective against glioma. Conclusion: A substantial amount of data on the inverse association between atopic conditions and glioma has accumulated, and findings from the GICC study further strengthen the existing evidence that the relationship between atopy and glioma is unlikely to be coincidental. Impact: As the literature approaches a consensus on the impact of allergies in glioma risk, future research can begin to shift focus to what the underlying biologic mechanism behind this association may be, which could, in turn, yield new opportunities for immunotherapy or cancer prevention.
AB - Background: Several previous studies have found inverse associations between glioma susceptibility and a history of allergies or other atopic conditions. Some evidence indicates that respiratory allergies are likely to be particularly relevant with regard to glioma risk. Using data from the Glioma International Case-Control Study (GICC), we examined the effects of respiratory allergies and other atopic conditions on glioma risk. Methods: The GICC contains detailed information on history of atopic conditions for 4,533 cases and 4,171 controls, recruited from 14 study sites across five countries. Using two-stage randomeffects restricted maximum likelihood modeling to calculate meta-analysis ORs, we examined the associations between glioma and allergy status, respiratory allergy status, asthma, and eczema. Results: Having a history of respiratory allergies was associated with an approximately 30% lower glioma risk, compared with not having respiratory allergies (mOR, 0.72; 95% confidence interval, 0.58-0.90). This association was similar when restricting to highgrade glioma cases. Asthma and eczema were also significantly protective against glioma. Conclusion: A substantial amount of data on the inverse association between atopic conditions and glioma has accumulated, and findings from the GICC study further strengthen the existing evidence that the relationship between atopy and glioma is unlikely to be coincidental. Impact: As the literature approaches a consensus on the impact of allergies in glioma risk, future research can begin to shift focus to what the underlying biologic mechanism behind this association may be, which could, in turn, yield new opportunities for immunotherapy or cancer prevention.
UR - http://www.scopus.com/inward/record.url?scp=84957806090&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84957806090&partnerID=8YFLogxK
U2 - 10.1158/1055-9965.EPI-15-0847
DO - 10.1158/1055-9965.EPI-15-0847
M3 - Article
C2 - 26908595
AN - SCOPUS:84957806090
VL - 25
SP - 282
EP - 290
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
SN - 1055-9965
IS - 2
ER -