Approach to diagnosis

Raghuwansh P. Sah, Suresh T Chari

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Autoimmune pancreatitis (AIP) is a rare disease which is characteristically responsive to steroid treatment. Its clinical presentation mimics that of pancreatic cancer which is far more common than AIP. The price of misdiagnosis is heavy as AIP mistaken for pancreatic cancer leads to major pancreatic surgery. Similarly, pancreatic cancer misdiagnosed as AIP leads to delay in diagnosis and possible progression of cancer while receiving steroid therapy. Recently, international consensus diagnostic criteria have been formulated for the diagnosis of AIP and to distinguish it from pancreatic cancer. These criteria utilize a combination of histology, pancreatic imaging features, evidence of extrapancreatic manifestations, IgG4 serology, and response to steroid treatment. Histological confirmation of AIP is difficult preoperatively; however, noninvasive diagnosis of AIP can be made in about 50 % of patients based on radiological and serological features. In a select group of patients with specific features, a diagnostic steroid trial is appropriate. About 20 % of patients do not have any evidence of extrapancreatic organ involvement or IgG4 serum elevation; in these patients, histological confirmation is required to definitively diagnose AIP.

Original languageEnglish (US)
Title of host publicationAutoimmune (IgG4-Related) Pancreatitis and Cholangitis
PublisherSpringer New York
Pages95-99
Number of pages5
ISBN (Print)9781441964304, 1441964290, 9781441964298
DOIs
StatePublished - Feb 1 2014

Fingerprint

Pancreatitis
Pancreatic Neoplasms
Steroids
Diagnostic Errors
Immunoglobulin G
Serology
Rare Diseases
Histology
Therapeutics
Serum
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sah, R. P., & Chari, S. T. (2014). Approach to diagnosis. In Autoimmune (IgG4-Related) Pancreatitis and Cholangitis (pp. 95-99). Springer New York. https://doi.org/10.1007/978-1-4419-6430-4_9

Approach to diagnosis. / Sah, Raghuwansh P.; Chari, Suresh T.

Autoimmune (IgG4-Related) Pancreatitis and Cholangitis. Springer New York, 2014. p. 95-99.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sah, RP & Chari, ST 2014, Approach to diagnosis. in Autoimmune (IgG4-Related) Pancreatitis and Cholangitis. Springer New York, pp. 95-99. https://doi.org/10.1007/978-1-4419-6430-4_9
Sah RP, Chari ST. Approach to diagnosis. In Autoimmune (IgG4-Related) Pancreatitis and Cholangitis. Springer New York. 2014. p. 95-99 https://doi.org/10.1007/978-1-4419-6430-4_9
Sah, Raghuwansh P. ; Chari, Suresh T. / Approach to diagnosis. Autoimmune (IgG4-Related) Pancreatitis and Cholangitis. Springer New York, 2014. pp. 95-99
@inbook{f87b23ddf94444e7954195f267088994,
title = "Approach to diagnosis",
abstract = "Autoimmune pancreatitis (AIP) is a rare disease which is characteristically responsive to steroid treatment. Its clinical presentation mimics that of pancreatic cancer which is far more common than AIP. The price of misdiagnosis is heavy as AIP mistaken for pancreatic cancer leads to major pancreatic surgery. Similarly, pancreatic cancer misdiagnosed as AIP leads to delay in diagnosis and possible progression of cancer while receiving steroid therapy. Recently, international consensus diagnostic criteria have been formulated for the diagnosis of AIP and to distinguish it from pancreatic cancer. These criteria utilize a combination of histology, pancreatic imaging features, evidence of extrapancreatic manifestations, IgG4 serology, and response to steroid treatment. Histological confirmation of AIP is difficult preoperatively; however, noninvasive diagnosis of AIP can be made in about 50 {\%} of patients based on radiological and serological features. In a select group of patients with specific features, a diagnostic steroid trial is appropriate. About 20 {\%} of patients do not have any evidence of extrapancreatic organ involvement or IgG4 serum elevation; in these patients, histological confirmation is required to definitively diagnose AIP.",
author = "Sah, {Raghuwansh P.} and Chari, {Suresh T}",
year = "2014",
month = "2",
day = "1",
doi = "10.1007/978-1-4419-6430-4_9",
language = "English (US)",
isbn = "9781441964304",
pages = "95--99",
booktitle = "Autoimmune (IgG4-Related) Pancreatitis and Cholangitis",
publisher = "Springer New York",

}

TY - CHAP

T1 - Approach to diagnosis

AU - Sah, Raghuwansh P.

AU - Chari, Suresh T

PY - 2014/2/1

Y1 - 2014/2/1

N2 - Autoimmune pancreatitis (AIP) is a rare disease which is characteristically responsive to steroid treatment. Its clinical presentation mimics that of pancreatic cancer which is far more common than AIP. The price of misdiagnosis is heavy as AIP mistaken for pancreatic cancer leads to major pancreatic surgery. Similarly, pancreatic cancer misdiagnosed as AIP leads to delay in diagnosis and possible progression of cancer while receiving steroid therapy. Recently, international consensus diagnostic criteria have been formulated for the diagnosis of AIP and to distinguish it from pancreatic cancer. These criteria utilize a combination of histology, pancreatic imaging features, evidence of extrapancreatic manifestations, IgG4 serology, and response to steroid treatment. Histological confirmation of AIP is difficult preoperatively; however, noninvasive diagnosis of AIP can be made in about 50 % of patients based on radiological and serological features. In a select group of patients with specific features, a diagnostic steroid trial is appropriate. About 20 % of patients do not have any evidence of extrapancreatic organ involvement or IgG4 serum elevation; in these patients, histological confirmation is required to definitively diagnose AIP.

AB - Autoimmune pancreatitis (AIP) is a rare disease which is characteristically responsive to steroid treatment. Its clinical presentation mimics that of pancreatic cancer which is far more common than AIP. The price of misdiagnosis is heavy as AIP mistaken for pancreatic cancer leads to major pancreatic surgery. Similarly, pancreatic cancer misdiagnosed as AIP leads to delay in diagnosis and possible progression of cancer while receiving steroid therapy. Recently, international consensus diagnostic criteria have been formulated for the diagnosis of AIP and to distinguish it from pancreatic cancer. These criteria utilize a combination of histology, pancreatic imaging features, evidence of extrapancreatic manifestations, IgG4 serology, and response to steroid treatment. Histological confirmation of AIP is difficult preoperatively; however, noninvasive diagnosis of AIP can be made in about 50 % of patients based on radiological and serological features. In a select group of patients with specific features, a diagnostic steroid trial is appropriate. About 20 % of patients do not have any evidence of extrapancreatic organ involvement or IgG4 serum elevation; in these patients, histological confirmation is required to definitively diagnose AIP.

UR - http://www.scopus.com/inward/record.url?scp=84930321495&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930321495&partnerID=8YFLogxK

U2 - 10.1007/978-1-4419-6430-4_9

DO - 10.1007/978-1-4419-6430-4_9

M3 - Chapter

AN - SCOPUS:84930321495

SN - 9781441964304

SN - 1441964290

SN - 9781441964298

SP - 95

EP - 99

BT - Autoimmune (IgG4-Related) Pancreatitis and Cholangitis

PB - Springer New York

ER -