TY - JOUR
T1 - Applied nanotechnology and nanoscience in orthopedic oncology
AU - Savvidou, Olga D.
AU - Bolia, Ioanna K.
AU - Chloros, George D.
AU - Goumenos, Stavros D.
AU - Sakellariou, Vasileios I.
AU - Galanis, Evanthia C.
AU - Papagelopoulos, Panayiotis J.
N1 - Publisher Copyright:
Copyright © SLACK Incorporated.
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Nanomedicine is based on the fact that biological molecules behave similarly to nanomolecules, which have a size of less than 100 nm, and is now affecting most areas of orthopedics. In orthopedic oncology, most of the in vitro and in vivo studies have used osteosarcoma or Ewing sarcoma cell lineages. In this article, tumor imaging and treatment nanotechnology applications, including nanostructure delivery of chemotherapeutic agents, gene therapy, and the role of nano-selenium-coated implants, are outlined. Finally, the potential role of nanotechnology in addressing the challenges of drug and radiotherapy resistance is discussed.
AB - Nanomedicine is based on the fact that biological molecules behave similarly to nanomolecules, which have a size of less than 100 nm, and is now affecting most areas of orthopedics. In orthopedic oncology, most of the in vitro and in vivo studies have used osteosarcoma or Ewing sarcoma cell lineages. In this article, tumor imaging and treatment nanotechnology applications, including nanostructure delivery of chemotherapeutic agents, gene therapy, and the role of nano-selenium-coated implants, are outlined. Finally, the potential role of nanotechnology in addressing the challenges of drug and radiotherapy resistance is discussed.
UR - http://www.scopus.com/inward/record.url?scp=84989963070&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84989963070&partnerID=8YFLogxK
U2 - 10.3928/01477447-20160823-03
DO - 10.3928/01477447-20160823-03
M3 - Article
C2 - 27636683
AN - SCOPUS:84989963070
SN - 0147-7447
VL - 39
SP - 280
EP - 286
JO - Orthopedics
JF - Orthopedics
IS - 5
ER -