Applications of SPR for the characterization of molecules important in the pathogenesis and treatment of neurodegenerative diseases

Nathan J. Wittenberg, Bharath Wootla, Luke R. Jordan, Aleksandar Denic, Arthur E. Warrington, Sang Hyun Oh, Moses Rodriguez

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Characterization of binding kinetics and affinity between a potential drug and its receptor are key steps in the development of new drugs. Among the techniques available to determine binding affinities, surface plasmon resonance has emerged as the gold standard because it can measure binding and dissociation rates in real-time in a label-free fashion. Surface plasmon resonance is now finding applications in the characterization of molecules for treatment of neurodegenerative diseases, characterization of molecules associated with pathogenesis of neurodegenerative diseases and detection of neurodegenerative disease biomarkers. In addition it has been used in the characterization of a new class of natural autoantibodies that have therapeutic potential in a number of neurologic diseases. In this review we will introduce surface plasmon resonance and describe some applications of the technique that pertain to neurodegenerative disorders and their treatment.

Original languageEnglish (US)
Pages (from-to)449-463
Number of pages15
JournalExpert Review of Neurotherapeutics
Volume14
Issue number4
DOIs
StatePublished - 2014

Fingerprint

Neurodegenerative Diseases
Surface Plasmon Resonance
Drug Receptors
Nervous System Diseases
Autoantibodies
Biomarkers
Pharmaceutical Preparations
Therapeutics

Keywords

  • Alzheimer's disease
  • Amyloid-beta
  • Antibodies
  • Biomarkers
  • Lipid bilayer membrane
  • Multiple sclerosis
  • Neuromyelitis optica
  • Surface modification
  • Surface plasmon resonance

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Pharmacology (medical)

Cite this

Applications of SPR for the characterization of molecules important in the pathogenesis and treatment of neurodegenerative diseases. / Wittenberg, Nathan J.; Wootla, Bharath; Jordan, Luke R.; Denic, Aleksandar; Warrington, Arthur E.; Oh, Sang Hyun; Rodriguez, Moses.

In: Expert Review of Neurotherapeutics, Vol. 14, No. 4, 2014, p. 449-463.

Research output: Contribution to journalArticle

Wittenberg, Nathan J. ; Wootla, Bharath ; Jordan, Luke R. ; Denic, Aleksandar ; Warrington, Arthur E. ; Oh, Sang Hyun ; Rodriguez, Moses. / Applications of SPR for the characterization of molecules important in the pathogenesis and treatment of neurodegenerative diseases. In: Expert Review of Neurotherapeutics. 2014 ; Vol. 14, No. 4. pp. 449-463.
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