Applications of SPR for the characterization of molecules important in the pathogenesis and treatment of neurodegenerative diseases

Nathan J. Wittenberg, Bharath Wootla, Luke R. Jordan, Aleksandar Denic, Arthur E. Warrington, Sang Hyun Oh, Moses Rodriguez

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

Characterization of binding kinetics and affinity between a potential drug and its receptor are key steps in the development of new drugs. Among the techniques available to determine binding affinities, surface plasmon resonance has emerged as the gold standard because it can measure binding and dissociation rates in real-time in a label-free fashion. Surface plasmon resonance is now finding applications in the characterization of molecules for treatment of neurodegenerative diseases, characterization of molecules associated with pathogenesis of neurodegenerative diseases and detection of neurodegenerative disease biomarkers. In addition it has been used in the characterization of a new class of natural autoantibodies that have therapeutic potential in a number of neurologic diseases. In this review we will introduce surface plasmon resonance and describe some applications of the technique that pertain to neurodegenerative disorders and their treatment.

Original languageEnglish (US)
Pages (from-to)449-463
Number of pages15
JournalExpert review of neurotherapeutics
Volume14
Issue number4
DOIs
StatePublished - Apr 2014

Keywords

  • Alzheimer's disease
  • Amyloid-beta
  • Antibodies
  • Biomarkers
  • Lipid bilayer membrane
  • Multiple sclerosis
  • Neuromyelitis optica
  • Surface modification
  • Surface plasmon resonance

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Applications of SPR for the characterization of molecules important in the pathogenesis and treatment of neurodegenerative diseases'. Together they form a unique fingerprint.

  • Cite this