Applications of magnetic resonance elastography to healthy and pathologic skeletal muscle

Stacie I. Ringleb, Sabine F. Bensamoun, Qingshan Chen, Armando Manduca, Kai Nan An, Richard Lorne Ehman

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Magnetic resonance elastography (MRE) Is capable of non-invasively quantifying the mechanical properties of skeletal muscles in vivo. This information can be clinically useful to understand the effects of pathologies on the mechanical properties of muscle and to quantify the effects of treatment. Advances in inversion algorithms quantify muscle anisotropy in two-dimensional (2D) and three-dimensional (3D) imaging. Databases of the shear stiffness of skeletal muscle have been presented in the relaxed and contracted states in the upper extremity (biceps brachii, flexor digitorum profundus, and upper trapezius), distal leg muscles (tibialis anterior, medial gastrocnemius, lateral gastrocnemius, and trapezius), and proximal leg muscles (vastus lateralis, vastus medialis, and sartorius). MRE measurements have successfully validated a mathematical model of skeletal muscle behavior in the biceps brachii, correlated to electromyographic data in the distal leg muscles and quantified the effects of pathologies on the distal and proximal leg muscles. Future research efforts should be directed toward improving one-dimensional (1D) and 3D MRE data acquisition and image processing, tracking the effects of treatment on pathologic muscle and correlating the shear stiffness with clinical measurements.

Original languageEnglish (US)
Pages (from-to)301-309
Number of pages9
JournalJournal of Magnetic Resonance Imaging
Volume25
Issue number2
DOIs
StatePublished - Feb 2007

Fingerprint

Elasticity Imaging Techniques
Skeletal Muscle
Muscles
Leg
Superficial Back Muscles
Quadriceps Muscle
Pathology
Three-Dimensional Imaging
Anisotropy
Upper Extremity
Theoretical Models
Databases

Keywords

  • Biomechanics
  • Elastic properties
  • Magnetic resonance elastography
  • Shear stiffness
  • Skeletal muscle

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Applications of magnetic resonance elastography to healthy and pathologic skeletal muscle. / Ringleb, Stacie I.; Bensamoun, Sabine F.; Chen, Qingshan; Manduca, Armando; An, Kai Nan; Ehman, Richard Lorne.

In: Journal of Magnetic Resonance Imaging, Vol. 25, No. 2, 02.2007, p. 301-309.

Research output: Contribution to journalArticle

Ringleb, Stacie I. ; Bensamoun, Sabine F. ; Chen, Qingshan ; Manduca, Armando ; An, Kai Nan ; Ehman, Richard Lorne. / Applications of magnetic resonance elastography to healthy and pathologic skeletal muscle. In: Journal of Magnetic Resonance Imaging. 2007 ; Vol. 25, No. 2. pp. 301-309.
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