TY - JOUR
T1 - Applications of a new handheld reference point indentation instrument measuring bone material strength
AU - Randall, Connor
AU - Bridges, Daniel
AU - Guerri, Roberto
AU - Nogues, Xavier
AU - Puig, Lluis
AU - Torres, Elisa
AU - Mellibovsky, Leonardo
AU - Hoffseth, Kevin
AU - Stalbaum, Tyler
AU - Srikanth, Ananya
AU - Weaver, James C.
AU - Rosen, Sasha
AU - Barnard, Heather
AU - Brimer, Davis
AU - Proctor, Alex
AU - Candy, James
AU - Saldana, Christopher
AU - Chandrasekar, Srinivasan
AU - Lescun, Timothy
AU - Nielson, Carrie M.
AU - Orwoll, Eric
AU - Herthel, Doug
AU - Kopeikin, Hal
AU - Yang, Henry T.Y.
AU - Farr, Joshua N.
AU - McCready, Louise
AU - Khosla, Sundeep
AU - Diez-Perez, Adolfo
AU - Hansma, Paul K.
PY - 2013/9/24
Y1 - 2013/9/24
N2 - A novel, hand-held Reference Point Indentation (RPI) instrument, measures how well thebone of living patients and large animals resists indentation. The results presented hereare reported in terms of Bone Material Strength, which is a normalized measure of howwell the bone resists indentation, and is inversely related to the indentation distance intothe bone. We present examples of the instrument's use in: (1) laboratory experiments onbone, including experiments through a layer of soft tissue, (2) three human clinical trials,two ongoing in Barcelona and at the Mayo Clinic, and one completed in Portland, OR,and (3) two ongoing horse clinical trials, one at Purdue University and another at AlamoPintado Stables in California. The instrument is capable of measuring consistent valueswhen testing through soft tissue such as skin and periosteum, and does so handheld, animprovement over previous Reference Point Indentation instruments. Measurements conductedon horses showed reproducible results when testing the horse through tissue or onbare bone. In the human clinical trials, reasonable and consistent values were obtained,suggesting the OsteoprobeVR is capable of measuring Bone Material Strength in vivo, butlarger studies are needed to determine the efficacy of the instrument's use in medical diagnosis.
AB - A novel, hand-held Reference Point Indentation (RPI) instrument, measures how well thebone of living patients and large animals resists indentation. The results presented hereare reported in terms of Bone Material Strength, which is a normalized measure of howwell the bone resists indentation, and is inversely related to the indentation distance intothe bone. We present examples of the instrument's use in: (1) laboratory experiments onbone, including experiments through a layer of soft tissue, (2) three human clinical trials,two ongoing in Barcelona and at the Mayo Clinic, and one completed in Portland, OR,and (3) two ongoing horse clinical trials, one at Purdue University and another at AlamoPintado Stables in California. The instrument is capable of measuring consistent valueswhen testing through soft tissue such as skin and periosteum, and does so handheld, animprovement over previous Reference Point Indentation instruments. Measurements conductedon horses showed reproducible results when testing the horse through tissue or onbare bone. In the human clinical trials, reasonable and consistent values were obtained,suggesting the OsteoprobeVR is capable of measuring Bone Material Strength in vivo, butlarger studies are needed to determine the efficacy of the instrument's use in medical diagnosis.
KW - Bone
KW - Bone Fracture
KW - Bone Material Properties
KW - Bone Mechanical Properties
UR - http://www.scopus.com/inward/record.url?scp=84885079143&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84885079143&partnerID=8YFLogxK
U2 - 10.1115/1.4024829
DO - 10.1115/1.4024829
M3 - Article
AN - SCOPUS:84885079143
SN - 1932-6181
VL - 7
JO - Journal of Medical Devices, Transactions of the ASME
JF - Journal of Medical Devices, Transactions of the ASME
IS - 4
M1 - 041005
ER -