Application of the national institute on aging-alzheimer's association AD criteria to ADNI

Val J. Lowe, Patrick J. Peller, Stephen D. Weigand, Catalina Montoya Quintero, Nirubol Tosakulwong, Prashanthi Vemuri, Matthew L. Senjem, Lennon Jordan, Clifford R. Jack, David Knopman, Ronald C. Petersen

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Abstract

Objective: Wedescribe the operationalization of theNational Institute on Aging-Alzheimer's Association (NIA-AA) workgroup diagnostic guidelines pertaining to Alzheimer disease (AD) dementia in a large multicenter group of subjects with AD dementia. Methods: Subjects with AD dementia from the Alzheimer's Disease Neuroimaging Initiative (ADNI) with at least 1 amyloid biomarker (n = 211) were included in this report. Biomarker data from CSF Aβ42, amyloid PET, fluorodeoxyglucose-PET, and MRI were examined. The biomarker results were assessed on a per-patient basis and the subject categorization as defined in theNIA-AAworkgroup guidelines was determined. Results: When using a requirement that subjects have a positive amyloid biomarker and single neuronal injury marker having an AD pattern, 87% (48% for both neuronal injury biomarkers) of the subjects could be categorized as "high probability" for AD. Amyloid status of the combined Pittsburgh compound B-PET and CSF results showed an amyloid-negative rate of 10% in the AD group. In the ADNI AD group, 5 of 92 subjects fit the category "dementia unlikely due to AD" when at least one neuronal injury marker was negative. Conclusions: A large proportion of subjects with AD dementia in ADNI may be categorized more definitively as high-probability AD using the proposed biomarker scheme in the NIA-AA criteria. A minority of subjects may be excluded from the diagnosis of AD by using biomarkers in clinically categorized AD subjects. In a well-defined AD dementia population, significant biomarker inconsistency can be seen on a per-patient basis.

Original languageEnglish (US)
Pages (from-to)2130-2137
Number of pages8
JournalNeurology
Volume80
Issue number23
DOIs
StatePublished - Jun 4 2013

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ASJC Scopus subject areas

  • Clinical Neurology

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