Application of pharmacogenomics to vaccines

Gregory A. Poland, Inna G. Ovsyannikova, Robert M. Jacobson

Research output: Contribution to journalReview article

77 Scopus citations

Abstract

The field of pharmacogenomics and pharmacogenetics provides a promising science base for vaccine research and development. A broad range of phenotype/genotype data combined with high-throughput genetic sequencing and bioinformatics are increasingly being integrated into this emerging field of vaccinomics. This paper discusses the hypothesis of the 'immune response gene network' and genetic (and bioinformatic) strategies to study associations between immune response gene polymorphisms and variations in humoral and cellular immune responses to prophylactic viral vaccines, such as measles-mumps-rubella, influenza, HIV, hepatitis B and smallpox. Immunogenetic studies reveal promising new vaccine targets by providing a better understanding of the mechanisms by which gene polymorphisms may influence innate and adaptive immune responses to vaccines, including vaccine failure and vaccine-associated adverse events. Additional benefits from vaccinomic studies include the development of personalized vaccines, the development of novel vaccines and the development of novel vaccine adjuvants.

Original languageEnglish (US)
Pages (from-to)837-852
Number of pages16
JournalPharmacogenomics
Volume10
Issue number5
DOIs
StatePublished - 2009

Keywords

  • Genetic association
  • Genetic predisposition to disease
  • Immunization
  • Immunogenetics
  • Vaccination
  • Vaccine

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmacology

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    Poland, G. A., Ovsyannikova, I. G., & Jacobson, R. M. (2009). Application of pharmacogenomics to vaccines. Pharmacogenomics, 10(5), 837-852. https://doi.org/10.2217/pgs.09.25