Application of next-generation sequencing in gastrointestinal and liver tumors

Sameh Mikhail, Bishoy Faltas, Mohamed E. Salem, Tanios Bekaii-Saab

Research output: Contribution to journalShort survey

3 Scopus citations

Abstract

Malignant transformation of normal cells is associated with the evolution of genomic alterations. This concept has led to the development of molecular testing platforms to identify genomic alterations that can be targeted with novel therapies. Next generation sequencing (NGS) has heralded a new era in precision medicine in which tumor genes can be studied efficiently. Recent developments in NGS have allowed investigators to identify genomic predictive makers and hereditary mutations to guide treatment decision. The application of NGS in gastrointestinal cancers is being extensively studied but continues to face substantial challenges. In our review, we discuss various NGS platforms and highlight their role in identifying familial mutations and markers of response or resistance to cancer therapy. We also provide a balanced discussion of the challenges that limit the routine use of NGS in clinical practice.

Original languageEnglish (US)
Pages (from-to)187-191
Number of pages5
JournalCancer Letters
Volume374
Issue number2
DOIs
StatePublished - May 1 2016
Externally publishedYes

Keywords

  • Challenges
  • Clinical application
  • Gastrointestinal cancer
  • Next generation sequencing
  • Predictive markers

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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