Application of magnetic resonance imaging to measure fasting and postprandial volumes in humans

J. Fidler, A. E. Bharucha, M. Camilleri, J. Camp, D. Burton, R. Grimm, S. J. Riederer, R. A. Robb, A. R. Zinsmeister

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Our aims were to measure the gastric volume response in excess of ingested meal volume (i.e. gastric accommodation), contribution of swallowed air to this excess, day-to-day variability of gastric volumes measured by MRI and their relationship to volumes measured by single-photon-emission computed tomography (SPECT). In 20 healthy volunteers, fasting and postprandial gastric volumes were measured after technetium99m-pertechnetate labeling of the gastric mucosa by SPECT and separately by MRI, using 3D gradient echo and 2D half-Fourier acquisition single-shot turbo spin echo (HASTE) sequences. Ten of these subjects had a second MRI exam to assess intra-individual variation. Thereafter, another 10 subjects had two MRI studies during which they ingested the nutrient in 30 or 150 mL aliquots. During MRI, the postprandial gastric volume change exceeded the ingested meal volume by 106 ± 12 mL (Mean ± SEM). The HASTE and gradient echo sequences distinguished air from fluid under fasting and postprandial conditions respectively. This postprandial excess mainly comprised air (61 ± 5 mL), which was not significantly different when ingested as 30 or 150 mL aliquots. Fasting and postprandial gastric volumes measured by MRI were generally reproducible within subjects. During SPECT, postprandial volumes increased by 158 ± 18 mL; gastric volumes measured by SPECT were higher than MRI. MRI measures gastric volumes with acceptable performance characteristics; the postprandial excess primarily consists of air, which is not affected by the mode of ingestion. Gastric volumes are technique specific and differ between MRI and SPECT.

Original languageEnglish (US)
Pages (from-to)42-51
Number of pages10
JournalNeurogastroenterology and Motility
Volume21
Issue number1
DOIs
StatePublished - Jan 2009

Keywords

  • Gastric accommodation
  • Gastric volumes
  • Magnetic resonance imaging
  • Reproducibility
  • SPECT
  • Stomach

ASJC Scopus subject areas

  • Physiology
  • Endocrine and Autonomic Systems
  • Gastroenterology

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