Application of Biomarkers in Cancer Epidemiology

Montserrat García-Closas, Roel Vermeulen, Mark E. Sherman, Lee E. Moore, Martyn T. Smith, Nathaniel Rothman

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Biomarkers are increasingly being incorporated into epidemiologic studies of cancer etiology, often referred to as molecular epidemiology. This chapter focuses on the use of biomarkers in the context of etiologic research. It begins with a discussion of the development and characterization of biomarkers for use in epidemiologic studies, with a particular emphasis on understanding the components of variance and their impact on estimates of disease risk. It then discusses key issues in the use of exposure, intermediate end points, genetic susceptibility, and tumor biomarkers; and reviews the main epidemiologic study designs that use biomarkers. The chapter concludes with comments on collecting and processing biologic samples for use in molecula.

Original languageEnglish (US)
Title of host publicationCancer Epidemiology and Prevention
PublisherOxford University Press
ISBN (Electronic)9780199865062
ISBN (Print)0195149610, 9780195149616
DOIs
StatePublished - Sep 1 2009

Keywords

  • Cancer etiology
  • Cancer risk
  • Epidemiological studies
  • Molecular epidemiology
  • Variance

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    García-Closas, M., Vermeulen, R., Sherman, M. E., Moore, L. E., Smith, M. T., & Rothman, N. (2009). Application of Biomarkers in Cancer Epidemiology. In Cancer Epidemiology and Prevention Oxford University Press. https://doi.org/10.1093/acprof:oso/9780195149616.003.0006