Application of Attenuation Measuring Ultrasound Shearwave Elastography in 8 post-transplant liver patients

Ivan Z. Nenadic, Matthew W. Urban, Heng Zhao, William Sanchez, Paige E. Morgan, James F. Greenleaf, Shigao Chen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

16 Scopus citations

Abstract

Ultrasound and magnetic resonance elastography techniques are used to assess mechanical properties of soft tissues. Tissue stiffness is related to various pathologies such as fibrosis, loss of compliance and cancer. The basic principle of elastography methods is measuring shear wave velocity in tissue due to intrinsic motion or an external source of vibration, and relating the velocity to tissue elasticity. All tissue are inherently viscoelastic and ignoring viscosity biases the velocity-based estimates of elasticity and ignores a potentially important parameter of tissue health. We present Attenuation Measuring Ultrasound Shearwave Elastography (AMUSE), a technique that independently measures both shear wave velocity and attenuation in tissue and therefore allows model-free measurement of tissue elasticity and viscosity. Theoretical basis for AMUSE is first derived and validated in finite element simulations and polyvinyl alcohol and excised liver phantoms. AMUSE is used to measure shear wave velocity and attenuation in 8 transplanted livers in patients with potential acute rejection, and the results were compared with the biopsy findings in a blind study. The comparison showed excellent agreement and suggests that AMUSE can be used to separate livers with acute rejection from livers with no rejection.

Original languageEnglish (US)
Title of host publicationIEEE International Ultrasonics Symposium, IUS
PublisherIEEE Computer Society
Pages987-990
Number of pages4
ISBN (Electronic)9781479970490
DOIs
StatePublished - Oct 20 2014
Event2014 IEEE International Ultrasonics Symposium, IUS 2014 - Chicago, United States
Duration: Sep 3 2014Sep 6 2014

Publication series

NameIEEE International Ultrasonics Symposium, IUS
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Other

Other2014 IEEE International Ultrasonics Symposium, IUS 2014
CountryUnited States
CityChicago
Period9/3/149/6/14

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Keywords

  • liver transplant
  • shear wave attenuation
  • shear wave velocity
  • ultrasound vibrometry

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Cite this

Nenadic, I. Z., Urban, M. W., Zhao, H., Sanchez, W., Morgan, P. E., Greenleaf, J. F., & Chen, S. (2014). Application of Attenuation Measuring Ultrasound Shearwave Elastography in 8 post-transplant liver patients. In IEEE International Ultrasonics Symposium, IUS (pp. 987-990). [6932285] (IEEE International Ultrasonics Symposium, IUS). IEEE Computer Society. https://doi.org/10.1109/ULTSYM.2014.0242