Application of Acoustoelasticity to Evaluate Nonlinear Modulus in ex vivo Kidneys

Sara Aristizabal, Carolina Amador, Ivan Z. Nenadic, James F Greenleaf, Matthew W Urban

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Currently, dynamic elastography techniques estimate the linear elastic shear modulus of different body tissues. New methods that investigate other properties of soft tissues such as anisotropy, viscosity and shear nonlinearity would provide more information about the structure and function of the tissue and might provide a better contrast than tissue stiffness and hence provide more effective diagnostic tools for some diseases. It has previously been shown that shear wave velocity in a medium changes due to an applied stress, a phenomenon called acoustoelasticity (AE). Applying a stress to compress a medium while measuring the shear wave velocity versus strain provides data with which the third order nonlinear shear modulus, A, can be estimated. To evaluate the feasibility of estimating A, we evaluated ten ex vivo porcine kidneys embedded in 10% porcine gelatin to mimic the case of a transplanted kidney. Under assumptions of an elastic incompressible medium for the AE measurements, the shear modulus was quantified at each compression level and the applied strain was assessed by measuring the change in thickness of the kidney cortex. Finally, A was calculated by applying the AE theory. Our results demonstrated that it is possible to estimate a nonlinear shear modulus by monitoring the changes in strain and μ due to kidney deformation. The magnitudes of A are higher when the compression is performed progressively and when using a plate attached to the transducer. Nevertheless, the values obtained for A are similar to those previously reported in the literature for breast tissue.

Original languageEnglish (US)
JournalIEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
DOIs
StateAccepted/In press - Dec 7 2017

Fingerprint

kidneys
Elasticity
Tissue
shear
Elastic moduli
Shear waves
S waves
cortexes
gelatins
estimates
breast
Transducers
stiffness
transducers
Anisotropy
estimating
nonlinearity
Stiffness
Viscosity
viscosity

Keywords

  • Acoustics
  • Acoustoelasticity
  • Biological tissues
  • Elastography
  • Kidney
  • Kidney
  • Media
  • Nonlinearity
  • Shear modulus
  • Shear wave
  • Strain
  • Stress

ASJC Scopus subject areas

  • Instrumentation
  • Acoustics and Ultrasonics
  • Electrical and Electronic Engineering

Cite this

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title = "Application of Acoustoelasticity to Evaluate Nonlinear Modulus in ex vivo Kidneys",
abstract = "Currently, dynamic elastography techniques estimate the linear elastic shear modulus of different body tissues. New methods that investigate other properties of soft tissues such as anisotropy, viscosity and shear nonlinearity would provide more information about the structure and function of the tissue and might provide a better contrast than tissue stiffness and hence provide more effective diagnostic tools for some diseases. It has previously been shown that shear wave velocity in a medium changes due to an applied stress, a phenomenon called acoustoelasticity (AE). Applying a stress to compress a medium while measuring the shear wave velocity versus strain provides data with which the third order nonlinear shear modulus, A, can be estimated. To evaluate the feasibility of estimating A, we evaluated ten ex vivo porcine kidneys embedded in 10{\%} porcine gelatin to mimic the case of a transplanted kidney. Under assumptions of an elastic incompressible medium for the AE measurements, the shear modulus was quantified at each compression level and the applied strain was assessed by measuring the change in thickness of the kidney cortex. Finally, A was calculated by applying the AE theory. Our results demonstrated that it is possible to estimate a nonlinear shear modulus by monitoring the changes in strain and μ due to kidney deformation. The magnitudes of A are higher when the compression is performed progressively and when using a plate attached to the transducer. Nevertheless, the values obtained for A are similar to those previously reported in the literature for breast tissue.",
keywords = "Acoustics, Acoustoelasticity, Biological tissues, Elastography, Kidney, Kidney, Media, Nonlinearity, Shear modulus, Shear wave, Strain, Stress",
author = "Sara Aristizabal and Carolina Amador and Nenadic, {Ivan Z.} and Greenleaf, {James F} and Urban, {Matthew W}",
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AU - Amador, Carolina

AU - Nenadic, Ivan Z.

AU - Greenleaf, James F

AU - Urban, Matthew W

PY - 2017/12/7

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N2 - Currently, dynamic elastography techniques estimate the linear elastic shear modulus of different body tissues. New methods that investigate other properties of soft tissues such as anisotropy, viscosity and shear nonlinearity would provide more information about the structure and function of the tissue and might provide a better contrast than tissue stiffness and hence provide more effective diagnostic tools for some diseases. It has previously been shown that shear wave velocity in a medium changes due to an applied stress, a phenomenon called acoustoelasticity (AE). Applying a stress to compress a medium while measuring the shear wave velocity versus strain provides data with which the third order nonlinear shear modulus, A, can be estimated. To evaluate the feasibility of estimating A, we evaluated ten ex vivo porcine kidneys embedded in 10% porcine gelatin to mimic the case of a transplanted kidney. Under assumptions of an elastic incompressible medium for the AE measurements, the shear modulus was quantified at each compression level and the applied strain was assessed by measuring the change in thickness of the kidney cortex. Finally, A was calculated by applying the AE theory. Our results demonstrated that it is possible to estimate a nonlinear shear modulus by monitoring the changes in strain and μ due to kidney deformation. The magnitudes of A are higher when the compression is performed progressively and when using a plate attached to the transducer. Nevertheless, the values obtained for A are similar to those previously reported in the literature for breast tissue.

AB - Currently, dynamic elastography techniques estimate the linear elastic shear modulus of different body tissues. New methods that investigate other properties of soft tissues such as anisotropy, viscosity and shear nonlinearity would provide more information about the structure and function of the tissue and might provide a better contrast than tissue stiffness and hence provide more effective diagnostic tools for some diseases. It has previously been shown that shear wave velocity in a medium changes due to an applied stress, a phenomenon called acoustoelasticity (AE). Applying a stress to compress a medium while measuring the shear wave velocity versus strain provides data with which the third order nonlinear shear modulus, A, can be estimated. To evaluate the feasibility of estimating A, we evaluated ten ex vivo porcine kidneys embedded in 10% porcine gelatin to mimic the case of a transplanted kidney. Under assumptions of an elastic incompressible medium for the AE measurements, the shear modulus was quantified at each compression level and the applied strain was assessed by measuring the change in thickness of the kidney cortex. Finally, A was calculated by applying the AE theory. Our results demonstrated that it is possible to estimate a nonlinear shear modulus by monitoring the changes in strain and μ due to kidney deformation. The magnitudes of A are higher when the compression is performed progressively and when using a plate attached to the transducer. Nevertheless, the values obtained for A are similar to those previously reported in the literature for breast tissue.

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KW - Stress

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