Appendicealmucinous neoplasms: Diagnosis andmanagement

Walid L. Shaib, Rita Assi, Ali Shamseddine, Olatunji B. Alese, Charles Staley, Bahar Memis, Volkan Adsay, Tanios Bekaii-Saab, Bassel F. El-Rayes

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Objective. Appendiceal mucinous neoplasms (AMNs) are a rare and heterogeneous disease for which clinical management is challenging. We aim to review the literature regarding modalities of treatment to guide the management of AMNs. Methods and Review Criteria.We conducted a PubMed search in February 2016 for English-language publications, using the terms “appendiceal, ” “appendix, ” “carcinoma, ” “cancer, ” “mucinous, ” “treatment, ” “genes, ” “target, ” “genomic, ” and terms listed in the articles’ subheadings. Published reports and abstracts from the American Society of Clinical Oncology meetings were also searched. Results. In this review, we summarize current data and controversies in AMN classification, clinical presentation, molecular alterations, treatment outcomes with regard to cytoreductive surgery, hyperthermic intraperitoneal chemotherapy (HIPEC), and the role of systemic chemotherapy. Conclusion. Appendiceal mucinous neoplasms are a heterogeneous group of tumors with a rising incidence. Treatment is based on stage and histology. Low-grade tumors are treated surgically with resection of the primary site in early stage disease, or peritoneal debulking and HIPEC in patients with advanced stage disease. Treatment of high-grade tumors requires further prospective trials, and options include debulking surgery and HIPEC with or without preoperative chemotherapy. Trials evaluating novel therapies based on the molecular profiling of AMN tumors are needed to evaluate therapeutic options in patients who are not surgical candidates.

Original languageEnglish (US)
Pages (from-to)1107-1116
Number of pages10
JournalOncologist
Volume22
Issue number9
DOIs
StatePublished - Sep 1 2017

Fingerprint

Appendiceal Neoplasms
Drug Therapy
Neoplasms
Peritoneal Diseases
Therapeutics
Mucinous Adenocarcinoma
Rare Diseases
PubMed
Publications
Histology
Language
Incidence

Keywords

  • Abdominal surgery
  • Appendix carcinoma
  • Review

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Shaib, W. L., Assi, R., Shamseddine, A., Alese, O. B., Staley, C., Memis, B., ... El-Rayes, B. F. (2017). Appendicealmucinous neoplasms: Diagnosis andmanagement. Oncologist, 22(9), 1107-1116. https://doi.org/10.1634/theoncologist.2017-0081

Appendicealmucinous neoplasms : Diagnosis andmanagement. / Shaib, Walid L.; Assi, Rita; Shamseddine, Ali; Alese, Olatunji B.; Staley, Charles; Memis, Bahar; Adsay, Volkan; Bekaii-Saab, Tanios; El-Rayes, Bassel F.

In: Oncologist, Vol. 22, No. 9, 01.09.2017, p. 1107-1116.

Research output: Contribution to journalReview article

Shaib, WL, Assi, R, Shamseddine, A, Alese, OB, Staley, C, Memis, B, Adsay, V, Bekaii-Saab, T & El-Rayes, BF 2017, 'Appendicealmucinous neoplasms: Diagnosis andmanagement', Oncologist, vol. 22, no. 9, pp. 1107-1116. https://doi.org/10.1634/theoncologist.2017-0081
Shaib WL, Assi R, Shamseddine A, Alese OB, Staley C, Memis B et al. Appendicealmucinous neoplasms: Diagnosis andmanagement. Oncologist. 2017 Sep 1;22(9):1107-1116. https://doi.org/10.1634/theoncologist.2017-0081
Shaib, Walid L. ; Assi, Rita ; Shamseddine, Ali ; Alese, Olatunji B. ; Staley, Charles ; Memis, Bahar ; Adsay, Volkan ; Bekaii-Saab, Tanios ; El-Rayes, Bassel F. / Appendicealmucinous neoplasms : Diagnosis andmanagement. In: Oncologist. 2017 ; Vol. 22, No. 9. pp. 1107-1116.
@article{094f4c87e95a4b56bca88f1ec4d2e09d,
title = "Appendicealmucinous neoplasms: Diagnosis andmanagement",
abstract = "Objective. Appendiceal mucinous neoplasms (AMNs) are a rare and heterogeneous disease for which clinical management is challenging. We aim to review the literature regarding modalities of treatment to guide the management of AMNs. Methods and Review Criteria.We conducted a PubMed search in February 2016 for English-language publications, using the terms “appendiceal, ” “appendix, ” “carcinoma, ” “cancer, ” “mucinous, ” “treatment, ” “genes, ” “target, ” “genomic, ” and terms listed in the articles’ subheadings. Published reports and abstracts from the American Society of Clinical Oncology meetings were also searched. Results. In this review, we summarize current data and controversies in AMN classification, clinical presentation, molecular alterations, treatment outcomes with regard to cytoreductive surgery, hyperthermic intraperitoneal chemotherapy (HIPEC), and the role of systemic chemotherapy. Conclusion. Appendiceal mucinous neoplasms are a heterogeneous group of tumors with a rising incidence. Treatment is based on stage and histology. Low-grade tumors are treated surgically with resection of the primary site in early stage disease, or peritoneal debulking and HIPEC in patients with advanced stage disease. Treatment of high-grade tumors requires further prospective trials, and options include debulking surgery and HIPEC with or without preoperative chemotherapy. Trials evaluating novel therapies based on the molecular profiling of AMN tumors are needed to evaluate therapeutic options in patients who are not surgical candidates.",
keywords = "Abdominal surgery, Appendix carcinoma, Review",
author = "Shaib, {Walid L.} and Rita Assi and Ali Shamseddine and Alese, {Olatunji B.} and Charles Staley and Bahar Memis and Volkan Adsay and Tanios Bekaii-Saab and El-Rayes, {Bassel F.}",
year = "2017",
month = "9",
day = "1",
doi = "10.1634/theoncologist.2017-0081",
language = "English (US)",
volume = "22",
pages = "1107--1116",
journal = "Oncologist",
issn = "1083-7159",
publisher = "AlphaMed Press",
number = "9",

}

TY - JOUR

T1 - Appendicealmucinous neoplasms

T2 - Diagnosis andmanagement

AU - Shaib, Walid L.

AU - Assi, Rita

AU - Shamseddine, Ali

AU - Alese, Olatunji B.

AU - Staley, Charles

AU - Memis, Bahar

AU - Adsay, Volkan

AU - Bekaii-Saab, Tanios

AU - El-Rayes, Bassel F.

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Objective. Appendiceal mucinous neoplasms (AMNs) are a rare and heterogeneous disease for which clinical management is challenging. We aim to review the literature regarding modalities of treatment to guide the management of AMNs. Methods and Review Criteria.We conducted a PubMed search in February 2016 for English-language publications, using the terms “appendiceal, ” “appendix, ” “carcinoma, ” “cancer, ” “mucinous, ” “treatment, ” “genes, ” “target, ” “genomic, ” and terms listed in the articles’ subheadings. Published reports and abstracts from the American Society of Clinical Oncology meetings were also searched. Results. In this review, we summarize current data and controversies in AMN classification, clinical presentation, molecular alterations, treatment outcomes with regard to cytoreductive surgery, hyperthermic intraperitoneal chemotherapy (HIPEC), and the role of systemic chemotherapy. Conclusion. Appendiceal mucinous neoplasms are a heterogeneous group of tumors with a rising incidence. Treatment is based on stage and histology. Low-grade tumors are treated surgically with resection of the primary site in early stage disease, or peritoneal debulking and HIPEC in patients with advanced stage disease. Treatment of high-grade tumors requires further prospective trials, and options include debulking surgery and HIPEC with or without preoperative chemotherapy. Trials evaluating novel therapies based on the molecular profiling of AMN tumors are needed to evaluate therapeutic options in patients who are not surgical candidates.

AB - Objective. Appendiceal mucinous neoplasms (AMNs) are a rare and heterogeneous disease for which clinical management is challenging. We aim to review the literature regarding modalities of treatment to guide the management of AMNs. Methods and Review Criteria.We conducted a PubMed search in February 2016 for English-language publications, using the terms “appendiceal, ” “appendix, ” “carcinoma, ” “cancer, ” “mucinous, ” “treatment, ” “genes, ” “target, ” “genomic, ” and terms listed in the articles’ subheadings. Published reports and abstracts from the American Society of Clinical Oncology meetings were also searched. Results. In this review, we summarize current data and controversies in AMN classification, clinical presentation, molecular alterations, treatment outcomes with regard to cytoreductive surgery, hyperthermic intraperitoneal chemotherapy (HIPEC), and the role of systemic chemotherapy. Conclusion. Appendiceal mucinous neoplasms are a heterogeneous group of tumors with a rising incidence. Treatment is based on stage and histology. Low-grade tumors are treated surgically with resection of the primary site in early stage disease, or peritoneal debulking and HIPEC in patients with advanced stage disease. Treatment of high-grade tumors requires further prospective trials, and options include debulking surgery and HIPEC with or without preoperative chemotherapy. Trials evaluating novel therapies based on the molecular profiling of AMN tumors are needed to evaluate therapeutic options in patients who are not surgical candidates.

KW - Abdominal surgery

KW - Appendix carcinoma

KW - Review

UR - http://www.scopus.com/inward/record.url?scp=85029649368&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85029649368&partnerID=8YFLogxK

U2 - 10.1634/theoncologist.2017-0081

DO - 10.1634/theoncologist.2017-0081

M3 - Review article

C2 - 28663356

AN - SCOPUS:85029649368

VL - 22

SP - 1107

EP - 1116

JO - Oncologist

JF - Oncologist

SN - 1083-7159

IS - 9

ER -