Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: Cause or effect?

Research output: Contribution to journalReview article

148 Scopus citations

Abstract

Increasing evidence suggests that selective neuronal loss in neurodegenerative diseases involves activation of cysteine aspartyl proteases (caspases), which initiate and execute apoptosis. In Alzheimer disease both extracellular amyloid deposits and intracellular amyloid β protein may activate caspases, leading to cleavage of nuclear and cytoskeletal proteins, including tau protein. Proteolysis of tau may be critical to neurofibrillary degeneration, which correlates with dementia (see the related article beginning on page 121).

Original languageEnglish (US)
Pages (from-to)23-27
Number of pages5
JournalJournal of Clinical Investigation
Volume114
Issue number1
DOIs
StatePublished - Jul 2004

ASJC Scopus subject areas

  • Medicine(all)

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