TY - JOUR
T1 - Apoptotic mechanisms in Alzheimer neurofibrillary degeneration
T2 - Cause or effect?
AU - Dickson, Dennis W
PY - 2004/7
Y1 - 2004/7
N2 - Increasing evidence suggests that selective neuronal loss in neurodegenerative diseases involves activation of cysteine aspartyl proteases (caspases), which initiate and execute apoptosis. In Alzheimer disease both extracellular amyloid deposits and intracellular amyloid β protein may activate caspases, leading to cleavage of nuclear and cytoskeletal proteins, including tau protein. Proteolysis of tau may be critical to neurofibrillary degeneration, which correlates with dementia (see the related article beginning on page 121).
AB - Increasing evidence suggests that selective neuronal loss in neurodegenerative diseases involves activation of cysteine aspartyl proteases (caspases), which initiate and execute apoptosis. In Alzheimer disease both extracellular amyloid deposits and intracellular amyloid β protein may activate caspases, leading to cleavage of nuclear and cytoskeletal proteins, including tau protein. Proteolysis of tau may be critical to neurofibrillary degeneration, which correlates with dementia (see the related article beginning on page 121).
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U2 - 10.1172/JCI200422317
DO - 10.1172/JCI200422317
M3 - Article
C2 - 15232608
SN - 0021-9738
VL - 114
SP - 23
EP - 27
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
IS - 1
ER -