Apoptosis in the treatment of cancer: a promise kept?

Xue Wei Meng, Sun Hee Lee, Scott H. Kaufmann

Research output: Contribution to journalReview articlepeer-review

60 Scopus citations

Abstract

A common feature of cancer cells is their ability to evade apoptosis as a result of alterations that block cell death signaling pathways. The extensive research efforts that elucidated these signaling pathways over the past decade have set the stage for the development of therapeutic agents that either kill cancer cells selectively or reset their apoptotic threshold. Over the past two years a number of these agents have been evaluated in preclinical and clinical trials. The results of these studies suggest that it might soon be possible to modulate apoptosis in cancer cells for therapeutic benefit.

Original languageEnglish (US)
Pages (from-to)668-676
Number of pages9
JournalCurrent Opinion in Cell Biology
Volume18
Issue number6
DOIs
StatePublished - Dec 2006

ASJC Scopus subject areas

  • Cell Biology

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