Apoptosis in the treatment of cancer

a promise kept?

Xue Wei Meng, Sun Hee Lee, Scott H Kaufmann

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

A common feature of cancer cells is their ability to evade apoptosis as a result of alterations that block cell death signaling pathways. The extensive research efforts that elucidated these signaling pathways over the past decade have set the stage for the development of therapeutic agents that either kill cancer cells selectively or reset their apoptotic threshold. Over the past two years a number of these agents have been evaluated in preclinical and clinical trials. The results of these studies suggest that it might soon be possible to modulate apoptosis in cancer cells for therapeutic benefit.

Original languageEnglish (US)
Pages (from-to)668-676
Number of pages9
JournalCurrent Opinion in Cell Biology
Volume18
Issue number6
DOIs
StatePublished - Dec 2006

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Apoptosis
Neoplasms
Cell Death
Clinical Trials
Therapeutics
Research

ASJC Scopus subject areas

  • Cell Biology

Cite this

Apoptosis in the treatment of cancer : a promise kept? / Meng, Xue Wei; Lee, Sun Hee; Kaufmann, Scott H.

In: Current Opinion in Cell Biology, Vol. 18, No. 6, 12.2006, p. 668-676.

Research output: Contribution to journalArticle

Meng, Xue Wei ; Lee, Sun Hee ; Kaufmann, Scott H. / Apoptosis in the treatment of cancer : a promise kept?. In: Current Opinion in Cell Biology. 2006 ; Vol. 18, No. 6. pp. 668-676.
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