Apoptosis: Basic concepts and implications in coronary artery disease

Patricia J.M. Best; David Hasdai; Giuseppe Sangiorgi; Robert S. Schwartz; David R. Holmes; Robert D. Simari; Amir Lerman

doi:10.1161/01.ATV.19.1.14

Apoptosis: Basic concepts and implications in coronary artery disease

Patricia J.M. Best, David Hasdai, Giuseppe Sangiorgi, Robert S. Schwartz, David R. Holmes, Robert D. Simari, Amir Lerman

Cardiovascular Medicine

Research output: Contribution to journal › Review article › peer-review

102 Scopus citations

Abstract

Apoptosis is an active form of cell death that is intricately regulated and distinct from necrosis. Data suggest that apoptosis may play a role in the pathophysiology of coronary atherosclerotic disease. Anatomic evidence of apoptosis has been observed in coronary atherosclerosis, restenosis, and transplant arteriopathy, accompanied by an increase in biochemical and genetic markers of apoptosis. Vasoactive substances such as nitric oxide and angiotensin II also regulate vascular smooth muscle cell apoptosis; vasodilating factors may induce apoptosis, whereas vasoconstricting factors may inhibit apoptosis. The aim of this article is to review key points regarding the detection of apoptosis, its regulation, and its possible role in the pathogenesis of coronary artery disease.

Original language	English (US)
Pages (from-to)	14-22
Number of pages	9
Journal	Arteriosclerosis, thrombosis, and vascular biology
Volume	19
Issue number	1
DOIs	https://doi.org/10.1161/01.ATV.19.1.14
State	Published - Jan 1999

Keywords

Apoptosis
Atherosclerosis
Cell death
Coronary disease
Restenosis

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1161/01.ATV.19.1.14

Cite this

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abstract = "Apoptosis is an active form of cell death that is intricately regulated and distinct from necrosis. Data suggest that apoptosis may play a role in the pathophysiology of coronary atherosclerotic disease. Anatomic evidence of apoptosis has been observed in coronary atherosclerosis, restenosis, and transplant arteriopathy, accompanied by an increase in biochemical and genetic markers of apoptosis. Vasoactive substances such as nitric oxide and angiotensin II also regulate vascular smooth muscle cell apoptosis; vasodilating factors may induce apoptosis, whereas vasoconstricting factors may inhibit apoptosis. The aim of this article is to review key points regarding the detection of apoptosis, its regulation, and its possible role in the pathogenesis of coronary artery disease.",

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T2 - Basic concepts and implications in coronary artery disease

AU - Best, Patricia J.M.

AU - Hasdai, David

AU - Sangiorgi, Giuseppe

AU - Schwartz, Robert S.

AU - Holmes, David R.

AU - Simari, Robert D.

AU - Lerman, Amir

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AB - Apoptosis is an active form of cell death that is intricately regulated and distinct from necrosis. Data suggest that apoptosis may play a role in the pathophysiology of coronary atherosclerotic disease. Anatomic evidence of apoptosis has been observed in coronary atherosclerosis, restenosis, and transplant arteriopathy, accompanied by an increase in biochemical and genetic markers of apoptosis. Vasoactive substances such as nitric oxide and angiotensin II also regulate vascular smooth muscle cell apoptosis; vasodilating factors may induce apoptosis, whereas vasoconstricting factors may inhibit apoptosis. The aim of this article is to review key points regarding the detection of apoptosis, its regulation, and its possible role in the pathogenesis of coronary artery disease.

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KW - Atherosclerosis

KW - Cell death

KW - Coronary disease

KW - Restenosis

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Apoptosis: Basic concepts and implications in coronary artery disease

Abstract

Keywords

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