TY - JOUR
T1 - Apoptosis and the response to anticancer therapy
AU - Mow, Benjamin M.F.
AU - Blajeski, April L.
AU - Chandra, Joya
AU - Kaufmann, Scott H.
PY - 2001
Y1 - 2001
N2 - Apoptosis is a distinctive form of cell death that reflects cleavage of a subset of intracellular polypeptides by proteases known as caspases. Two major intracellular caspase cascades, one activated predominately by death receptor ligands and the other triggered by various cellular stresses, including DNA damage and microtubule disruption, have been delineated. Activation of these protease cascades is tightly regulated by a number of polypeptides, including Bcl-2 family members, inhibitor of apoptosis proteins, and several protein kinases. The demonstration that many antineoplastic agents induce apoptosis in susceptible cells raises the possibility that factors affecting caspase activation and activity might be important determinants of anticancer drug sensitivity. Here, we review recent studies describing the regulation of apoptotic pathways and identify potential implications of these findings for resistance to antineoplastic agents.
AB - Apoptosis is a distinctive form of cell death that reflects cleavage of a subset of intracellular polypeptides by proteases known as caspases. Two major intracellular caspase cascades, one activated predominately by death receptor ligands and the other triggered by various cellular stresses, including DNA damage and microtubule disruption, have been delineated. Activation of these protease cascades is tightly regulated by a number of polypeptides, including Bcl-2 family members, inhibitor of apoptosis proteins, and several protein kinases. The demonstration that many antineoplastic agents induce apoptosis in susceptible cells raises the possibility that factors affecting caspase activation and activity might be important determinants of anticancer drug sensitivity. Here, we review recent studies describing the regulation of apoptotic pathways and identify potential implications of these findings for resistance to antineoplastic agents.
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U2 - 10.1097/00001622-200111000-00007
DO - 10.1097/00001622-200111000-00007
M3 - Review article
C2 - 11673685
AN - SCOPUS:0034765627
SN - 1040-8746
VL - 13
SP - 453
EP - 462
JO - Current Opinion in Oncology
JF - Current Opinion in Oncology
IS - 6
ER -