Abstract
The present study examined the levels of procaspases (zymogens of the main apoptosis enzymes, caspases) that are predicted based on application of the optimization principle. Optimization models have previously been successfully developed for many other physiological systems (e.g., circulation, oxygen transport system, fibrinolysis, and blood coagulation) but have not previously been applied to apoptotic biochemical pathways. Our model assumed that apoptotic pathways are designed to minimize protein consumption. Procaspase concentrations were predicted based on this assumption, along with known schemes of apoptosis reactions and kinetic constants for procaspase activation and target cleavage. Good agreement between the model predictions and actual procaspase levels was observed.
Original language | English (US) |
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Pages (from-to) | 449-459 |
Number of pages | 11 |
Journal | Computers in Biology and Medicine |
Volume | 34 |
Issue number | 5 |
DOIs | |
State | Published - Jul 2004 |
Keywords
- Apoptosis
- Minimum protein consumption
- Optimization problem
- Procaspase concentrations
ASJC Scopus subject areas
- Computer Science Applications
- Health Informatics