Apoptosis: An optimization approach

Michael A. Khanin, Aleksey N. Lobanov, Scott H. Kaufmann

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The present study examined the levels of procaspases (zymogens of the main apoptosis enzymes, caspases) that are predicted based on application of the optimization principle. Optimization models have previously been successfully developed for many other physiological systems (e.g., circulation, oxygen transport system, fibrinolysis, and blood coagulation) but have not previously been applied to apoptotic biochemical pathways. Our model assumed that apoptotic pathways are designed to minimize protein consumption. Procaspase concentrations were predicted based on this assumption, along with known schemes of apoptosis reactions and kinetic constants for procaspase activation and target cleavage. Good agreement between the model predictions and actual procaspase levels was observed.

Original languageEnglish (US)
Pages (from-to)449-459
Number of pages11
JournalComputers in Biology and Medicine
Volume34
Issue number5
DOIs
StatePublished - Jul 1 2004

Keywords

  • Apoptosis
  • Minimum protein consumption
  • Optimization problem
  • Procaspase concentrations

ASJC Scopus subject areas

  • Computer Science Applications
  • Health Informatics

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