Apoptosis: An optimization approach

Michael A. Khanin; Aleksey N. Lobanov; Scott H. Kaufmann

doi:10.1016/S0010-4825(03)00089-1

Apoptosis: An optimization approach

Michael A. Khanin, Aleksey N. Lobanov, Scott H. Kaufmann

Oncology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The present study examined the levels of procaspases (zymogens of the main apoptosis enzymes, caspases) that are predicted based on application of the optimization principle. Optimization models have previously been successfully developed for many other physiological systems (e.g., circulation, oxygen transport system, fibrinolysis, and blood coagulation) but have not previously been applied to apoptotic biochemical pathways. Our model assumed that apoptotic pathways are designed to minimize protein consumption. Procaspase concentrations were predicted based on this assumption, along with known schemes of apoptosis reactions and kinetic constants for procaspase activation and target cleavage. Good agreement between the model predictions and actual procaspase levels was observed.

Original language	English (US)
Pages (from-to)	449-459
Number of pages	11
Journal	Computers in Biology and Medicine
Volume	34
Issue number	5
DOIs	https://doi.org/10.1016/S0010-4825(03)00089-1
State	Published - Jul 2004

Keywords

Apoptosis
Minimum protein consumption
Optimization problem
Procaspase concentrations

ASJC Scopus subject areas

Computer Science Applications
Health Informatics

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AU - Lobanov, Aleksey N.

AU - Kaufmann, Scott H.

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AB - The present study examined the levels of procaspases (zymogens of the main apoptosis enzymes, caspases) that are predicted based on application of the optimization principle. Optimization models have previously been successfully developed for many other physiological systems (e.g., circulation, oxygen transport system, fibrinolysis, and blood coagulation) but have not previously been applied to apoptotic biochemical pathways. Our model assumed that apoptotic pathways are designed to minimize protein consumption. Procaspase concentrations were predicted based on this assumption, along with known schemes of apoptosis reactions and kinetic constants for procaspase activation and target cleavage. Good agreement between the model predictions and actual procaspase levels was observed.

KW - Apoptosis

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KW - Optimization problem

KW - Procaspase concentrations

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Apoptosis: An optimization approach

Abstract

Keywords

ASJC Scopus subject areas

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