Apolipoprotein E genotype does not affect the age of onset of dementia in families with defined tau mutations

Henry Houlden, Patrizia Rizzu, Martijn Stevens, Peter De Knijff, Cornelia M. Van Duijn, John C. Van Swieten, Peter Heutink, Jordi Perez-Tur, Valerie Thomas, Matt Baker, Huw Morris, Martin Rossor, John C. Jannsen, Ron C. Petersen, Peter Dodd, Frances Dark, Brad Boeve, Dennis Dickson, Peter Davies, Stuart Pickering-BrownDavid Mann, Jennifer Adamson, Tim Lynch, Haydeh Payami, Parvoneh Poorkaj, Thomas D. Bird, Gerald D. Schellenberg, Sumi Chakraverty, Joanne Norton, John C. Morris, Alison Goate, Mike Hutton, John Hardy

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

We have assessed whether apolipoprotein E (ApoE) genotype influences the age of onset of dementia in a series of families with frontal temporal dementia with defined mutations in the tau gene. In contrast to the situation in Alzheimer's disease (AD), we could find no evidence that the age of onset of disease was influenced by the ApoE genotype.

Original languageEnglish (US)
Pages (from-to)193-195
Number of pages3
JournalNeuroscience Letters
Volume260
Issue number3
DOIs
StatePublished - Feb 5 1999

Keywords

  • Alzheimer's disease
  • Apolipoprotein E
  • Frontotemporal dementia with parkinsonism linked to chromosome 17
  • Tau

ASJC Scopus subject areas

  • Neuroscience(all)

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    Houlden, H., Rizzu, P., Stevens, M., De Knijff, P., Van Duijn, C. M., Van Swieten, J. C., Heutink, P., Perez-Tur, J., Thomas, V., Baker, M., Morris, H., Rossor, M., Jannsen, J. C., Petersen, R. C., Dodd, P., Dark, F., Boeve, B., Dickson, D., Davies, P., ... Hardy, J. (1999). Apolipoprotein E genotype does not affect the age of onset of dementia in families with defined tau mutations. Neuroscience Letters, 260(3), 193-195. https://doi.org/10.1016/S0304-3940(98)00931-8