Apolipoprotein E as a β-amyloid-independent factor in Alzheimer's disease

Andrew B. Wolf, Jon Valla, Guojun D Bu, Jungsu Kim, Mary Jo Ladu, Eric M. Reiman, Richard John Caselli

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

APOE, which encodes apolipoprotein E, is the most prevalent and best established genetic risk factor for late-onset Alzheimer's disease. Current understanding of Alzheimer's disease pathophysiology posits an important role for apolipoprotein E in the disease cascade via its interplay with β-amyloid. However, evidence is also emerging for roles of apolipoprotein E in the disease process that are independent of β-amyloid. Particular areas of interest are lipid metabolism, tau pathology, neuroenergetics, neurodevelopment, synaptic plasticity, the neurovasculature, and neuroinflammation. The intent of this article is to review the literature in each of these areas.

Original languageEnglish (US)
Article number38
JournalAlzheimer's Research and Therapy
Volume5
Issue number5
DOIs
StatePublished - 2013

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Apolipoproteins E
Amyloid
Alzheimer Disease
Neuronal Plasticity
Lipid Metabolism
Pathology

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Cognitive Neuroscience

Cite this

Apolipoprotein E as a β-amyloid-independent factor in Alzheimer's disease. / Wolf, Andrew B.; Valla, Jon; Bu, Guojun D; Kim, Jungsu; Ladu, Mary Jo; Reiman, Eric M.; Caselli, Richard John.

In: Alzheimer's Research and Therapy, Vol. 5, No. 5, 38, 2013.

Research output: Contribution to journalArticle

Wolf, Andrew B. ; Valla, Jon ; Bu, Guojun D ; Kim, Jungsu ; Ladu, Mary Jo ; Reiman, Eric M. ; Caselli, Richard John. / Apolipoprotein E as a β-amyloid-independent factor in Alzheimer's disease. In: Alzheimer's Research and Therapy. 2013 ; Vol. 5, No. 5.
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