For the past two decades the epsilon 4 (ε4) allele of the Apolipoprotein E (APOE) gene has remained the only well established and greatest genetic risk factor for late-onset Alzheimer's disease (LOAD). ApoE is a 299-amino acid, 34.2 kDa, glycoprotein that has been implicated in multiple biological functions which will be described in this chapter. However, it is the evidence of its effect on β-amyloid metabolism that most strongly links this protein to the pathogenesis of LOAD.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)