Apolipoprotein e

Minerva M Carrasquillo, Guojun D Bu, Henrietta M. Nielsen

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

For the past two decades the epsilon 4 (ε4) allele of the Apolipoprotein E (APOE) gene has remained the only well established and greatest genetic risk factor for late-onset Alzheimer's disease (LOAD). ApoE is a 299-amino acid, 34.2 kDa, glycoprotein that has been implicated in multiple biological functions which will be described in this chapter. However, it is the evidence of its effect on β-amyloid metabolism that most strongly links this protein to the pathogenesis of LOAD.

Original languageEnglish (US)
Title of host publicationGenetic variants in Alzheimer's disease
PublisherSpringer New York
Pages7-23
Number of pages17
ISBN (Print)9781461473091, 146147308X, 9781461473084
DOIs
StatePublished - Apr 1 2013

Fingerprint

Apolipoproteins
Apolipoproteins E
Alzheimer Disease
Apolipoprotein E4
Amyloid
Metabolism
Glycoproteins
Genes
Alleles
Amino Acids
link protein

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Carrasquillo, M. M., Bu, G. D., & Nielsen, H. M. (2013). Apolipoprotein e. In Genetic variants in Alzheimer's disease (pp. 7-23). Springer New York. https://doi.org/10.1007/978-1-4614-7309-1_2

Apolipoprotein e. / Carrasquillo, Minerva M; Bu, Guojun D; Nielsen, Henrietta M.

Genetic variants in Alzheimer's disease. Springer New York, 2013. p. 7-23.

Research output: Chapter in Book/Report/Conference proceedingChapter

Carrasquillo, MM, Bu, GD & Nielsen, HM 2013, Apolipoprotein e. in Genetic variants in Alzheimer's disease. Springer New York, pp. 7-23. https://doi.org/10.1007/978-1-4614-7309-1_2
Carrasquillo MM, Bu GD, Nielsen HM. Apolipoprotein e. In Genetic variants in Alzheimer's disease. Springer New York. 2013. p. 7-23 https://doi.org/10.1007/978-1-4614-7309-1_2
Carrasquillo, Minerva M ; Bu, Guojun D ; Nielsen, Henrietta M. / Apolipoprotein e. Genetic variants in Alzheimer's disease. Springer New York, 2013. pp. 7-23
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