Apolipoprotein A-I as a marker of angiographically assessed coronary-artery disease

J. J. Maciejko, David Holmes, B. A. Kottke, A. R. Zinsmeister, D. M. Dinh, S. J. Mao

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Abstract

This study was designed to determine whether the plasma level of apolipoprotein A-I is a better discriminator of angiographically documented coronary-artery disease than the level of high-density-lipoprotein (HDL) cholesterol in male subjects. The level of plasma apolipoprotein A-I in 83 patients with coronary-artery disease was 96.7 ± 4.2 mg per deciliter (mean ± S.E.M.), which was significantly lower (P < 0.001) than the level in 25 patients without coronary-artery disease (146.9 ± 2.1 mg per deciliter). The levels of DHL cholesterol were also lower (P < 0.001) in patients with coronary-artery disease (31.9 ± 1.5 mg per deciliter) than in those without it (45.9 ± 2.3 mg per deciliter). A stepwise discriminant analysis, however, indicated the superiority of apolipoptrotin A-I over HDL cholesterol in detecting coronary-artery disease. Furthermore, a linear discriminant analysis suggested that although HDL cholesterol by itself was a discriminator of coronary-artery disease, it did not provide a substantial increase in discriminatory value over that provided by apolipoprotein A-I; in contrast, apolipoprotein A-I levels added discriminatory value to the information obtained by measuring HDL cholesterol alone. We conclude that apolipoprotein A-I by itself is more useful than HDL cholesterol for identifying patients with coronary-artery disease.

Original languageEnglish (US)
Pages (from-to)385-389
Number of pages5
JournalNew England Journal of Medicine
Volume309
Issue number7
StatePublished - 1983

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Apolipoprotein A-I
Coronary Artery Disease
HDL Cholesterol
Discriminant Analysis
Cholesterol

ASJC Scopus subject areas

  • Medicine(all)

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Maciejko, J. J., Holmes, D., Kottke, B. A., Zinsmeister, A. R., Dinh, D. M., & Mao, S. J. (1983). Apolipoprotein A-I as a marker of angiographically assessed coronary-artery disease. New England Journal of Medicine, 309(7), 385-389.

Apolipoprotein A-I as a marker of angiographically assessed coronary-artery disease. / Maciejko, J. J.; Holmes, David; Kottke, B. A.; Zinsmeister, A. R.; Dinh, D. M.; Mao, S. J.

In: New England Journal of Medicine, Vol. 309, No. 7, 1983, p. 385-389.

Research output: Contribution to journalArticle

Maciejko, JJ, Holmes, D, Kottke, BA, Zinsmeister, AR, Dinh, DM & Mao, SJ 1983, 'Apolipoprotein A-I as a marker of angiographically assessed coronary-artery disease', New England Journal of Medicine, vol. 309, no. 7, pp. 385-389.
Maciejko, J. J. ; Holmes, David ; Kottke, B. A. ; Zinsmeister, A. R. ; Dinh, D. M. ; Mao, S. J. / Apolipoprotein A-I as a marker of angiographically assessed coronary-artery disease. In: New England Journal of Medicine. 1983 ; Vol. 309, No. 7. pp. 385-389.
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