Apolipoprotein ∈4 allele frequency in young Africans of Ugandan descent versus African Americans

Floyd Banard Willis, Neill R Graff Radford, Martin Pinto, LaShaune Lawson, Jennifer Adamson, Dawn Epstein, Francine Parfitt, Mike Hutton, Peter C. O'Brien

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Through its role in lipid metabolism, Apolipoprotein ∈4 (ApoE4) may affect "brain repair" in stroke, brain hemorrhage, Alzheimer's disease, and other brain injury syndromes for which African Americans may have greater morbidity and mortality. Cross-cultural evaluations of these and other genetic factors may provide insight on possible ethnic differences in risk of morbidity to acute central nervous system (CNS) injury and chronic neurodegenerative processes. As an initial step toward expanding knowledge of ApoE allele frequencies for persons of African descent, we compared ApoE genotype of a group of 70 young Ugandans to 59 (subset of a larger group of 342 African Americans of all ages) age-matched African Americans and to published frequencies for Caucasians and Asians. We found that the ApoE4 and ∈2 alleles are more frequent in Ugandans (U) than Caucasians (C) or Asians (A) with corresponding alleles showing significant elevations of ∈2 (U 15.71%, C 8.40%, A 4.20%) and Î4 (U 25%, C 13.70%, A 8.90%) (p < .001). Comparing the differences between Ugandans and age-appropriate African Americans (AA) was not statically significant, but this outcome may be due to small sample size. These results provide the only published ApoE frequencies for Ugandans and the complete set of data provides the largest published community group of ApoE frequencies for African Americans.

Original languageEnglish (US)
Pages (from-to)71-76
Number of pages6
JournalJournal of the National Medical Association
Volume95
Issue number1
StatePublished - Jan 1 2003

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Apolipoproteins
Gene Frequency
African Americans
Apolipoproteins E
Alleles
Morbidity
Nervous System Trauma
Intracranial Hemorrhages
Lipid Metabolism
Sample Size
Brain Injuries
Alzheimer Disease
Central Nervous System
Stroke
Genotype
Mortality
Brain

Keywords

  • Alzheimer's disease
  • Apolipoprotein ∈

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Apolipoprotein ∈4 allele frequency in young Africans of Ugandan descent versus African Americans. / Willis, Floyd Banard; Graff Radford, Neill R; Pinto, Martin; Lawson, LaShaune; Adamson, Jennifer; Epstein, Dawn; Parfitt, Francine; Hutton, Mike; O'Brien, Peter C.

In: Journal of the National Medical Association, Vol. 95, No. 1, 01.01.2003, p. 71-76.

Research output: Contribution to journalArticle

Willis, FB, Graff Radford, NR, Pinto, M, Lawson, L, Adamson, J, Epstein, D, Parfitt, F, Hutton, M & O'Brien, PC 2003, 'Apolipoprotein ∈4 allele frequency in young Africans of Ugandan descent versus African Americans', Journal of the National Medical Association, vol. 95, no. 1, pp. 71-76.
Willis, Floyd Banard ; Graff Radford, Neill R ; Pinto, Martin ; Lawson, LaShaune ; Adamson, Jennifer ; Epstein, Dawn ; Parfitt, Francine ; Hutton, Mike ; O'Brien, Peter C. / Apolipoprotein ∈4 allele frequency in young Africans of Ugandan descent versus African Americans. In: Journal of the National Medical Association. 2003 ; Vol. 95, No. 1. pp. 71-76.
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