Apoe ε4 genotype and the risk for subjective cognitive impairment in elderly persons

Janina Krell-Roesch, Bryan K Woodruff, Jazmin I. Acosta, Dona E Locke, Joseph G. Hentz, Cynthia M Stonnington, Gorazd B. Stokin, Chelsea Nagle, Bernard F. Michel, Nathalie Sambuchi, Richard John Caselli, Yonas Endale Geda

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The authors compared the risk for subjective cognitive impairment (SCI) between carriers of the apolipoprotein E ε4 (APOE ε4) allele (cases) and APOE ε4 noncarriers (controls). SCI was assessed by a validated self-reported questionnaire. The authors used multivariable logistic regression analyses to compute odds ratios and 95% confidence intervals adjusted for age, sex, education, and marital status. Data were available on 114 participants (83 women; 47 APOE ε4 carriers; mean age, 69 years). The risk for SCI was significantly higher among cases than controls, particularly for those 70 years of age and older. These findings should be considered preliminary until confirmed by a prospective cohort study.

Original languageEnglish (US)
Pages (from-to)322-325
Number of pages4
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume27
Issue number4
DOIs
StatePublished - Sep 1 2015

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Apolipoprotein E4
Apolipoproteins E
Genotype
Sex Education
Marital Status
Cohort Studies
Logistic Models
Alleles
Odds Ratio
Regression Analysis
Prospective Studies
Confidence Intervals
Cognitive Dysfunction

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Neurology

Cite this

Apoe ε4 genotype and the risk for subjective cognitive impairment in elderly persons. / Krell-Roesch, Janina; Woodruff, Bryan K; Acosta, Jazmin I.; Locke, Dona E; Hentz, Joseph G.; Stonnington, Cynthia M; Stokin, Gorazd B.; Nagle, Chelsea; Michel, Bernard F.; Sambuchi, Nathalie; Caselli, Richard John; Geda, Yonas Endale.

In: Journal of Neuropsychiatry and Clinical Neurosciences, Vol. 27, No. 4, 01.09.2015, p. 322-325.

Research output: Contribution to journalArticle

Krell-Roesch, Janina ; Woodruff, Bryan K ; Acosta, Jazmin I. ; Locke, Dona E ; Hentz, Joseph G. ; Stonnington, Cynthia M ; Stokin, Gorazd B. ; Nagle, Chelsea ; Michel, Bernard F. ; Sambuchi, Nathalie ; Caselli, Richard John ; Geda, Yonas Endale. / Apoe ε4 genotype and the risk for subjective cognitive impairment in elderly persons. In: Journal of Neuropsychiatry and Clinical Neurosciences. 2015 ; Vol. 27, No. 4. pp. 322-325.
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