TY - JOUR
T1 - Apixaban and Rivaroxaban in Patients With Acute Venous Thromboembolism
AU - Bott-Kitslaar, Dalene M.
AU - McBane, Robert D.
AU - Casanegra, Ana I.
AU - Houghton, Damon E.
AU - Froehling, David A.
AU - Vlazny, Danielle T.
AU - Ashrani, Aneel A.
AU - Hodge, David O.
AU - Vargas, Emily R.
AU - Bartlett, Matthew A.
AU - Saadiq, Rayya A.
AU - Daniels, Paul R.
AU - Shields, Raymond C.
AU - Lenz, Charles J.
AU - Lang, Teresa R.
AU - Wysokinski, Waldemar E.
N1 - Funding Information:
Potential Competing Interests: Dr McBane has received research grant from Bristol-Myers Squibb/Pfzier Alliance, United States of America. The other authors report no competing interests. Grant Support: This work was partially supported by the discretionary fund from Gonda Vascular Center, Mayo Clinic Rochester, MN. Potential Competing Interests: Dr McBane has received research grant from Bristol-Myers Squibb/Pfzier Alliance, United States of America. The other authors report no competing interests. We thank Thrombophilia Clinic and Vascular Radiology personnel, nursing staff, schedulers, and desk attendants who assisted in this study. We especially thank Lisa G. Peterson, RN, for entering patient data into the REDCap (Research Electronic Data Capture) system and assisting in follow-up arrangement. Grant Support: This work was partially supported by the discretionary fund from Gonda Vascular Center, Mayo Clinic Rochester, MN. Potential Competing Interests: Dr McBane has received research grant from Bristol-Myers Squibb/Pfzier Alliance, United States of America. The other authors report no competing interests.
Funding Information:
Potential Competing Interests: Dr McBane has received research grant from Bristol-Myers Squibb/Pfzier Alliance, United States of America. The other authors report no competing interests.
Publisher Copyright:
© 2018 Mayo Foundation for Medical Education and Research
PY - 2019/7
Y1 - 2019/7
N2 - Objective: To compare the clinical efficacy and safety of apixaban with those of rivaroxaban for the treatment of acute venous thromboembolism (VTE). Patients and Methods: Consecutive patients enrolled in the Mayo Thrombophilia Clinic Registry (between March 1, 2013, and January 30, 2018) and treated with apixaban or rivaroxaban for acute VTE were followed forward in time. The primary efficacy outcome was VTE recurrence. The primary safety outcome was major bleeding; the second safety outcome was clinically relevant nonmajor bleeding (CRNMB); and the third was a composite of major bleeding or CRNMB. Results: Within the group of 1696 patients with VTE enrolled, 600 (38%) were treated either with apixaban (n=302, 50%) or rivaroxaban (n=298, 50%) within the first 14 days of VTE diagnosis and who completed at least 3 months of therapy or had a study event. Recurrent VTE was diagnosed in 7 patients (2.3%) treated with apixaban and in 6 (2%) treated with rivaroxaban (adjusted hazard ratio [aHR], 1.4; 95% CI, 0.5-3.8). Major bleeding occurred in 11 patients (3.6%) receiving apixaban and in 9 patients (3.0%) receiving rivaroxaban (aHR, 1.2; 95% CI, 0.5-3.2). Clinically relevant nonmajor bleeding was diagnosed in 7 patients (2.3%) receiving apixaban and in 20 (6.7%) receiving rivaroxaban (aHR, 0.4; 95% CI, 0.2-0.9). The rates of composite major bleeding or CRNMB were similar (aHR, 0.6; 95% CI, 0.3-1.2). Most study events occurred in patients with cancer. Conclusion: In the setting of a standardized, guideline-directed, patient-oriented clinical practice, the efficacy and safety of apixaban and rivaroxaban for the treatment of acute VTE were comparable.
AB - Objective: To compare the clinical efficacy and safety of apixaban with those of rivaroxaban for the treatment of acute venous thromboembolism (VTE). Patients and Methods: Consecutive patients enrolled in the Mayo Thrombophilia Clinic Registry (between March 1, 2013, and January 30, 2018) and treated with apixaban or rivaroxaban for acute VTE were followed forward in time. The primary efficacy outcome was VTE recurrence. The primary safety outcome was major bleeding; the second safety outcome was clinically relevant nonmajor bleeding (CRNMB); and the third was a composite of major bleeding or CRNMB. Results: Within the group of 1696 patients with VTE enrolled, 600 (38%) were treated either with apixaban (n=302, 50%) or rivaroxaban (n=298, 50%) within the first 14 days of VTE diagnosis and who completed at least 3 months of therapy or had a study event. Recurrent VTE was diagnosed in 7 patients (2.3%) treated with apixaban and in 6 (2%) treated with rivaroxaban (adjusted hazard ratio [aHR], 1.4; 95% CI, 0.5-3.8). Major bleeding occurred in 11 patients (3.6%) receiving apixaban and in 9 patients (3.0%) receiving rivaroxaban (aHR, 1.2; 95% CI, 0.5-3.2). Clinically relevant nonmajor bleeding was diagnosed in 7 patients (2.3%) receiving apixaban and in 20 (6.7%) receiving rivaroxaban (aHR, 0.4; 95% CI, 0.2-0.9). The rates of composite major bleeding or CRNMB were similar (aHR, 0.6; 95% CI, 0.3-1.2). Most study events occurred in patients with cancer. Conclusion: In the setting of a standardized, guideline-directed, patient-oriented clinical practice, the efficacy and safety of apixaban and rivaroxaban for the treatment of acute VTE were comparable.
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U2 - 10.1016/j.mayocp.2018.09.022
DO - 10.1016/j.mayocp.2018.09.022
M3 - Article
C2 - 30737059
AN - SCOPUS:85061032888
SN - 0025-6196
VL - 94
SP - 1242
EP - 1252
JO - Mayo Clinic Proceedings
JF - Mayo Clinic Proceedings
IS - 7
ER -