Apelinergic system in endothelial cells and its role in angiogenesis in myocardial ischemia

Vera Novakov, Gurpreet S. Sandhu, M. (Dan) Dragomir Daescu, Martin Klabusay

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Apelin is a peptide known to have a vital role in cardiovascular diseases. It has been proven to induce proliferation and tube formation in endothelial cells, stabilise contacts between endothelial cells, andmediate pericyte recruitment. Since apelin level is reduced early after myocardial infarction, a supportive therapywith apelin is being investigated for its beneficial effect on blood vessel formation. It is becoming apparent, however, that the final effect of apelin often depends on stimuli the cell receives and the cross-talk with othermolecules inside the cell. Hence, understanding the apelin pathway potentially can help us to improve angiogenic therapy. This review summarises recent knowledge regarding molecules involved in apelin signalling while focusing on their roles in angiogenesis within the ischemic environment after myocardial infarction.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalVascular Pharmacology
Volume76
DOIs
StatePublished - Apr 16 2015

Keywords

  • Angiogenesis
  • Apelin
  • Endothelial cells
  • Myocardial infarction
  • Signalling pathways

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine
  • Physiology

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