Abstract
Apelin is a peptide known to have a vital role in cardiovascular diseases. It has been proven to induce proliferation and tube formation in endothelial cells, stabilise contacts between endothelial cells, andmediate pericyte recruitment. Since apelin level is reduced early after myocardial infarction, a supportive therapywith apelin is being investigated for its beneficial effect on blood vessel formation. It is becoming apparent, however, that the final effect of apelin often depends on stimuli the cell receives and the cross-talk with othermolecules inside the cell. Hence, understanding the apelin pathway potentially can help us to improve angiogenic therapy. This review summarises recent knowledge regarding molecules involved in apelin signalling while focusing on their roles in angiogenesis within the ischemic environment after myocardial infarction.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-10 |
| Number of pages | 10 |
| Journal | Vascular Pharmacology |
| Volume | 76 |
| DOIs | |
| State | Published - Apr 16 2015 |
Keywords
- Angiogenesis
- Apelin
- Endothelial cells
- Myocardial infarction
- Signalling pathways
ASJC Scopus subject areas
- Physiology
- Molecular Medicine
- Pharmacology