Apathy associated with neurocognitive disorders: Recent progress and future directions

Krista L. Lanctôt, Luis Agüera-Ortiz, Henry Brodaty, Paul T. Francis, Yonas Endale Geda, Zahinoor Ismail, Gad A. Marshall, Moyra E. Mortby, Chiadi U. Onyike, Prasad R. Padala, Antonios M. Politis, Paul B. Rosenberg, Emma Siegel, David L. Sultzer, Eleenor H. Abraham

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Introduction: Apathy is common in neurocognitive disorders (NCDs) such as Alzheimer's disease and mild cognitive impairment. Although the definition of apathy is inconsistent in the literature, apathy is primarily defined as a loss of motivation and decreased interest in daily activities. Methods: The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) Neuropsychiatric Syndromes Professional Interest Area (NPS-PIA) Apathy workgroup reviewed the latest research regarding apathy in NCDs. Results: Progress has recently been made in three areas relevant to apathy: (1) phenomenology, including the use of diagnostic criteria and novel instruments for measurement, (2) neurobiology, including neuroimaging, neuropathological and biomarker correlates, and (3) interventions, including pharmacologic, nonpharmacologic, and noninvasive neuromodulatory approaches. Discussion: Recent progress confirms that apathy has a significant impact on those with major NCD and those with mild NCDs. As such, it is an important target for research and intervention.

Original languageEnglish (US)
JournalAlzheimer's and Dementia
DOIs
StateAccepted/In press - 2016

Fingerprint

Apathy
Research
Neurobiology
Neurocognitive Disorders
Direction compound
Neuroimaging
Motivation
Alzheimer Disease
Biomarkers

Keywords

  • Alzheimer's disease (AD)
  • Apathy
  • Mild behavioral impairment (MBI)
  • Neurocognitive disorders (NCD)
  • Neuropsychiatric symptoms (NPS)

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Geriatrics and Gerontology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health

Cite this

Lanctôt, K. L., Agüera-Ortiz, L., Brodaty, H., Francis, P. T., Geda, Y. E., Ismail, Z., ... Abraham, E. H. (Accepted/In press). Apathy associated with neurocognitive disorders: Recent progress and future directions. Alzheimer's and Dementia. https://doi.org/10.1016/j.jalz.2016.05.008

Apathy associated with neurocognitive disorders : Recent progress and future directions. / Lanctôt, Krista L.; Agüera-Ortiz, Luis; Brodaty, Henry; Francis, Paul T.; Geda, Yonas Endale; Ismail, Zahinoor; Marshall, Gad A.; Mortby, Moyra E.; Onyike, Chiadi U.; Padala, Prasad R.; Politis, Antonios M.; Rosenberg, Paul B.; Siegel, Emma; Sultzer, David L.; Abraham, Eleenor H.

In: Alzheimer's and Dementia, 2016.

Research output: Contribution to journalArticle

Lanctôt, KL, Agüera-Ortiz, L, Brodaty, H, Francis, PT, Geda, YE, Ismail, Z, Marshall, GA, Mortby, ME, Onyike, CU, Padala, PR, Politis, AM, Rosenberg, PB, Siegel, E, Sultzer, DL & Abraham, EH 2016, 'Apathy associated with neurocognitive disorders: Recent progress and future directions', Alzheimer's and Dementia. https://doi.org/10.1016/j.jalz.2016.05.008
Lanctôt, Krista L. ; Agüera-Ortiz, Luis ; Brodaty, Henry ; Francis, Paul T. ; Geda, Yonas Endale ; Ismail, Zahinoor ; Marshall, Gad A. ; Mortby, Moyra E. ; Onyike, Chiadi U. ; Padala, Prasad R. ; Politis, Antonios M. ; Rosenberg, Paul B. ; Siegel, Emma ; Sultzer, David L. ; Abraham, Eleenor H. / Apathy associated with neurocognitive disorders : Recent progress and future directions. In: Alzheimer's and Dementia. 2016.
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