Aortic valve calcification: Determinants and progression in the population

David Messika-Zeitoun, Lawrence F. Bielak, Patricia A. Peyser, Patrick F. Sheedy, Stephen T Turner, Vuyisile T Nkomo, Jerome F. Breen, Joseph Maalouf, Christopher Scott, A. Jamil Tajik, Maurice E Sarano

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

BACKGROUND - Aortic valve calcification (AVC) is considered degenerative. Recent data suggested links to atherosclerosis or coronary disease (CAD). METHODS AND RESULTS - AVC and coronary artery calcifications (CAC) were prospectively assessed by Electron-Beam-Computed-Tomography in 262 population-based research participants ≥60 years. AVC was frequent (27%) with aging (P<0.01) and in men (P<0.05). AVC was associated with diabetes, hypertension, higher body-mass-index, and serum glucose (all P<0.05). AVC was a marker of higher prevalence (P<0.01) and severity of CAD (CAC score: 441±802 versus 265±566, P<0.05) independently of age. After follow-up of 3.8±0.9 years, AVC score increased (94±271 versus 54±173, P<0.01, +11±32 U/year), faster with higher baseline AVC score (P<0.01). Compared with participants remaining free of AVC, de novo acquisition of AVC was associated with higher LDL-cholesterol (141±31 versus 121±27 mg/dL, P<0.05) and faster CAC progression (+78±87 versus +28±47 U/year, P<0.05). In multivariate analysis, LDL-cholesterol independently determined AVC acquisition while higher baseline AVC scores determined faster progression of existing AVC. CONCLUSION - In the population, AVC is frequent with aging and atherosclerotic risk factors. AVC is a marker of subclinical CAD. AVC is progressive, appearing de novo with progressive atherosclerosis whereas established AVC progresses independently of atherosclerotic risk factors and faster with increasing initial AVC loads.

Original languageEnglish (US)
Pages (from-to)642-648
Number of pages7
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume27
Issue number3
DOIs
StatePublished - Mar 2007

Fingerprint

Population
Coronary Disease
Coronary Vessels
Calcification of Aortic Valve
LDL Cholesterol
Atherosclerosis
X Ray Computed Tomography
Body Mass Index
Multivariate Analysis
Hypertension
Glucose
Serum
Research

Keywords

  • Aortic valve
  • Atherosclerosis
  • Calcification
  • Computed tomography
  • Epidemiology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Aortic valve calcification : Determinants and progression in the population. / Messika-Zeitoun, David; Bielak, Lawrence F.; Peyser, Patricia A.; Sheedy, Patrick F.; Turner, Stephen T; Nkomo, Vuyisile T; Breen, Jerome F.; Maalouf, Joseph; Scott, Christopher; Tajik, A. Jamil; Sarano, Maurice E.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 27, No. 3, 03.2007, p. 642-648.

Research output: Contribution to journalArticle

Messika-Zeitoun, D, Bielak, LF, Peyser, PA, Sheedy, PF, Turner, ST, Nkomo, VT, Breen, JF, Maalouf, J, Scott, C, Tajik, AJ & Sarano, ME 2007, 'Aortic valve calcification: Determinants and progression in the population', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 27, no. 3, pp. 642-648. https://doi.org/10.1161/01.ATV.0000255952.47980.c2
Messika-Zeitoun, David ; Bielak, Lawrence F. ; Peyser, Patricia A. ; Sheedy, Patrick F. ; Turner, Stephen T ; Nkomo, Vuyisile T ; Breen, Jerome F. ; Maalouf, Joseph ; Scott, Christopher ; Tajik, A. Jamil ; Sarano, Maurice E. / Aortic valve calcification : Determinants and progression in the population. In: Arteriosclerosis, Thrombosis, and Vascular Biology. 2007 ; Vol. 27, No. 3. pp. 642-648.
@article{dd2ed38f442d4af694b1d409bdf5e1d8,
title = "Aortic valve calcification: Determinants and progression in the population",
abstract = "BACKGROUND - Aortic valve calcification (AVC) is considered degenerative. Recent data suggested links to atherosclerosis or coronary disease (CAD). METHODS AND RESULTS - AVC and coronary artery calcifications (CAC) were prospectively assessed by Electron-Beam-Computed-Tomography in 262 population-based research participants ≥60 years. AVC was frequent (27{\%}) with aging (P<0.01) and in men (P<0.05). AVC was associated with diabetes, hypertension, higher body-mass-index, and serum glucose (all P<0.05). AVC was a marker of higher prevalence (P<0.01) and severity of CAD (CAC score: 441±802 versus 265±566, P<0.05) independently of age. After follow-up of 3.8±0.9 years, AVC score increased (94±271 versus 54±173, P<0.01, +11±32 U/year), faster with higher baseline AVC score (P<0.01). Compared with participants remaining free of AVC, de novo acquisition of AVC was associated with higher LDL-cholesterol (141±31 versus 121±27 mg/dL, P<0.05) and faster CAC progression (+78±87 versus +28±47 U/year, P<0.05). In multivariate analysis, LDL-cholesterol independently determined AVC acquisition while higher baseline AVC scores determined faster progression of existing AVC. CONCLUSION - In the population, AVC is frequent with aging and atherosclerotic risk factors. AVC is a marker of subclinical CAD. AVC is progressive, appearing de novo with progressive atherosclerosis whereas established AVC progresses independently of atherosclerotic risk factors and faster with increasing initial AVC loads.",
keywords = "Aortic valve, Atherosclerosis, Calcification, Computed tomography, Epidemiology",
author = "David Messika-Zeitoun and Bielak, {Lawrence F.} and Peyser, {Patricia A.} and Sheedy, {Patrick F.} and Turner, {Stephen T} and Nkomo, {Vuyisile T} and Breen, {Jerome F.} and Joseph Maalouf and Christopher Scott and Tajik, {A. Jamil} and Sarano, {Maurice E}",
year = "2007",
month = "3",
doi = "10.1161/01.ATV.0000255952.47980.c2",
language = "English (US)",
volume = "27",
pages = "642--648",
journal = "Arteriosclerosis, Thrombosis, and Vascular Biology",
issn = "1079-5642",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Aortic valve calcification

T2 - Determinants and progression in the population

AU - Messika-Zeitoun, David

AU - Bielak, Lawrence F.

AU - Peyser, Patricia A.

AU - Sheedy, Patrick F.

AU - Turner, Stephen T

AU - Nkomo, Vuyisile T

AU - Breen, Jerome F.

AU - Maalouf, Joseph

AU - Scott, Christopher

AU - Tajik, A. Jamil

AU - Sarano, Maurice E

PY - 2007/3

Y1 - 2007/3

N2 - BACKGROUND - Aortic valve calcification (AVC) is considered degenerative. Recent data suggested links to atherosclerosis or coronary disease (CAD). METHODS AND RESULTS - AVC and coronary artery calcifications (CAC) were prospectively assessed by Electron-Beam-Computed-Tomography in 262 population-based research participants ≥60 years. AVC was frequent (27%) with aging (P<0.01) and in men (P<0.05). AVC was associated with diabetes, hypertension, higher body-mass-index, and serum glucose (all P<0.05). AVC was a marker of higher prevalence (P<0.01) and severity of CAD (CAC score: 441±802 versus 265±566, P<0.05) independently of age. After follow-up of 3.8±0.9 years, AVC score increased (94±271 versus 54±173, P<0.01, +11±32 U/year), faster with higher baseline AVC score (P<0.01). Compared with participants remaining free of AVC, de novo acquisition of AVC was associated with higher LDL-cholesterol (141±31 versus 121±27 mg/dL, P<0.05) and faster CAC progression (+78±87 versus +28±47 U/year, P<0.05). In multivariate analysis, LDL-cholesterol independently determined AVC acquisition while higher baseline AVC scores determined faster progression of existing AVC. CONCLUSION - In the population, AVC is frequent with aging and atherosclerotic risk factors. AVC is a marker of subclinical CAD. AVC is progressive, appearing de novo with progressive atherosclerosis whereas established AVC progresses independently of atherosclerotic risk factors and faster with increasing initial AVC loads.

AB - BACKGROUND - Aortic valve calcification (AVC) is considered degenerative. Recent data suggested links to atherosclerosis or coronary disease (CAD). METHODS AND RESULTS - AVC and coronary artery calcifications (CAC) were prospectively assessed by Electron-Beam-Computed-Tomography in 262 population-based research participants ≥60 years. AVC was frequent (27%) with aging (P<0.01) and in men (P<0.05). AVC was associated with diabetes, hypertension, higher body-mass-index, and serum glucose (all P<0.05). AVC was a marker of higher prevalence (P<0.01) and severity of CAD (CAC score: 441±802 versus 265±566, P<0.05) independently of age. After follow-up of 3.8±0.9 years, AVC score increased (94±271 versus 54±173, P<0.01, +11±32 U/year), faster with higher baseline AVC score (P<0.01). Compared with participants remaining free of AVC, de novo acquisition of AVC was associated with higher LDL-cholesterol (141±31 versus 121±27 mg/dL, P<0.05) and faster CAC progression (+78±87 versus +28±47 U/year, P<0.05). In multivariate analysis, LDL-cholesterol independently determined AVC acquisition while higher baseline AVC scores determined faster progression of existing AVC. CONCLUSION - In the population, AVC is frequent with aging and atherosclerotic risk factors. AVC is a marker of subclinical CAD. AVC is progressive, appearing de novo with progressive atherosclerosis whereas established AVC progresses independently of atherosclerotic risk factors and faster with increasing initial AVC loads.

KW - Aortic valve

KW - Atherosclerosis

KW - Calcification

KW - Computed tomography

KW - Epidemiology

UR - http://www.scopus.com/inward/record.url?scp=33847014811&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33847014811&partnerID=8YFLogxK

U2 - 10.1161/01.ATV.0000255952.47980.c2

DO - 10.1161/01.ATV.0000255952.47980.c2

M3 - Article

C2 - 17185617

AN - SCOPUS:33847014811

VL - 27

SP - 642

EP - 648

JO - Arteriosclerosis, Thrombosis, and Vascular Biology

JF - Arteriosclerosis, Thrombosis, and Vascular Biology

SN - 1079-5642

IS - 3

ER -